Brain

Beer-Sheva, Israel, Nov. 24, 2014 - A new, enhanced MRI diagnostic approach was, for the first time, able to identify significant damage to the blood-brain barrier (BBB) of professional football players following "unreported" trauma or mild concussions. Published in the current issue of JAMA Neurology, this study could improve decision making on when an athlete should "return to play."

"Memetics," or the study of memes, is a very popular discipline among cultural researchers now, particularly as it concerns new media like viral videos. But no one seems to know what a meme really is.

ANN ARBOR--The medical community may be inadvertently creating a new generation of illegal, recreational drug users by prescribing anti-anxiety or sleep medications to teenagers, say University of Michigan researchers.

Teens prescribed anxiety or sleep medications are up to 12 times more likely to abuse those drugs than those who had never had a prescription, either by using someone else's prescription pills or to get high or experiment, according to a study from the U-M School of Nursing.

A protein that stimulates the brain to awaken from sleep may be a target for preventing Alzheimer's disease, a study by researchers at Washington University School of Medicine in St. Louis suggests.

In recent years, scientists at Washington University have established links between sleep problems and Alzheimer's. For example, they have shown in people and in mice that sleep loss contributes to the growth of brain plaques characteristic of Alzheimer's, and increases the risk of dementia.

There has been a growing concern that modern society is increasingly lonely. In 2006, a New York Times article "The Lonely American Just Got a Bit Lonelier" highlighted research that shows a decline in social engagement--people are less likely to join clubs, have fewer close friends, and are less likely to perceive others as trustworthy. However, studies have also shown an increase in extraversion and self-esteem, which suggests loneliness is decreasing.

Abnormal connections between neurons are the likely cause of motor coordination issues seen in autism spectrum disorder. Using a mouse model of autism, scientists from the University of Chicago identified a malfunctioning neural circuit associated with reduced capacity for motor learning. This appears to arise from an inability to eliminate unneeded neural connections in the brain. They report their findings Nov. 24 in Nature Communications.

Adult survivors of retinoblastoma, a type of eye cancer that usually develops in early childhood, have few cognitive or social problems decades following their diagnosis and treatment. That's the conclusion of a study published early online in CANCER, a peer-reviewed journal of the American Cancer Society. The findings offer good news for patients, but it's important to continue to monitor for long-term effects as the brain changes throughout life.

A gene associated with schizophrenia plays a role in brain development and may help to explain the biological process of the disease, according to new Rutgers research.

In the study, published in Biological Psychiatry, Bonnie Firestein, professor in the Department of Cell Biology and Neuroscience, says too much protein expressed by the NOS1AP gene, which has been associated with schizophrenia, causes abnormalities in brain structure and faulty connections between nerve cells that prevent them from communicating properly.

Babies start breathing in the womb, inhaling and exhaling irregularly at first, and then gradually more and more, until the day when they're born and have to do it all the time. But premature babies sometimes have trouble. They stop breathing periodically, sometimes for 20 or 30 seconds at a time. Sometimes they're fine, and sometimes they're not, and doctors struggle to help them. That may soon change, however, thanks to a two-month-old patient at UConn Health with a rare connexin mutation, and his doctor's willingness to call for help.

Repeat suicide attempts and deaths by suicide were roughly 25 percent lower among a group of Danish people who underwent voluntary short-term psychosocial counseling after a suicide attempt, new Johns Hopkins Bloomberg School of Public Health-led research suggests.

An intervention that uses music and games to help preschoolers learn self-regulation skills is helping prepare at-risk children for kindergarten, a new study from Oregon State University shows.

Self-regulation skills - the skills that help children pay attention, follow directions, stay on task and persist through difficulty - are critical to a child's success in kindergarten and beyond, said OSU's Megan McClelland, a nationally recognized expert in child development and a co-author of the new study.

You're at a slumber party with your friends. One friend asks "if a guy at school asked you out, but you weren't really attracted to him, would you go?" You laugh and shake your head no: "Why would I, if he's not my type?"

Or imagine you're at school, sitting in the cafeteria. A guy who you think is attractive but who has some unsuitable personality traits comes up and asks you out. You say yes, even though what you really meant to say was no. "Why did I do that?" you wonder.

Lugano/Geneva, Switzerland, 21 November 2014 - New evidence that immune checkpoint inhibitors may work in glioblastoma and brain metastases was presented today by Dr Anna Sophie Berghoff at the ESMO Symposium on Immuno-Oncology 2014 in Geneva, Switzerland.

LA JOLLA, CA - November 20, 2014 - Scientists at The Scripps Research Institute (TSRI) have discovered how one gene is essential to hearing, uncovering a cause of deafness and suggesting new avenues for therapies.

The new study, published November 20 in the journal Neuron, shows how mutations in a gene called Tmie can cause deafness from birth. Underlining the critical nature of their findings, researchers were able to reintroduce the gene in mice and restore the process underpinning hearing.

Stress activates the immune system

The team focused mainly on a certain type of phagocytes, namely microglia. Under normal circumstances, they repair synapses between nerves cells in the brain and stimulate their growth. Once activated, however, microglia may damage nerve cells and trigger inflammation processes. The studies carried out in Bochum have shown that the more frequently microglia get triggered due to stress, the more they are inclined to remain in the destructive mode - a risk factor for mental diseases such as schizophrenia.