Researchers at the RIKEN-Max Planck Joint Research Center in Japan have demonstrated that hallmark symptoms of Alzheimer's disease can be reduced when sugars are prevented from binding to one of the key enzymes implicated in the disease. The new findings, reported in EMBO Molecular Medicine, show that abnormal attachment of a particular sugar to the enzyme BACE1 is a critical factor leading to the formation of Aβ plaques in the brain, and that plaques were reduced and cognitive performance improved when this action was prevented in mice through loss of the enzyme GnT-III.
Brain
Depression and other behavior changes may show up in people who will later develop Alzheimer's disease even before they start having memory problems, according to a new study published in the January 14, 2015, online issue of Neurology®, the medical journal of the American Academy of Neurology.
The brains of some Iraq and Afghanistan combat veterans who survived blasts from improvised explosive devices (IEDs) and died later of other causes show a distinctive honeycomb pattern of broken and swollen nerve fibers throughout critical brain regions, including those that control executive function. The pattern is different from brain damage caused by car crashes, drug overdoses or collision sports, and may be the never-before-reported signature of blast injuries suffered by soldiers as far back as World War I.
Often enough it is human nature to conform. This tendency makes us follow the lead of computers, even if the machines give us the wrong advice. This is the finding of a study in Springer's journal Psychonomic Bulletin & Review that investigates how people make judgment calls after playing role-playing video games. The research was led by Ulrich Weger of the University of Witten/Herdecke in Germany.
Researchers studying the mechanism behind a protein dopamine transporter say their work could help in the development of future medical treatment against cocaine addiction. According to the European Monitoring Centre on Drugs and Drug Addiction, cocaine is the second most commonly used illegal drug in Europe, after cannabis.
A recent study demonstrated the potential of a virtual reality cognitive training game as a screening tool for patients with mild cognitive impairment (MCI) among a sample of older adults. MCI is a condition that often predates Alzheimer's disease (AD) and is characterized by memory loss and inability to execute complex activities such as financial planning.
A new study indicates that inherited viruses that are millions of years old play an important role in building up the complex networks that characterize the human brain.
Researchers have long been aware that endogenous retroviruses constitute around five percent of our DNA. For many years, it was unclear if they had a role - the colloquial term junk DNA was attached to them because they might have been a side-effect of our evolutionary journey.
The simple training exercise of catching a weighted medicine ball can improve balance and may help prevent falls in the elderly - and if you have a grandkid that wants to go out in the yard and toss a baseball, it will be good for both of them in many ways.
When someone is jostled by a bump or a stumble, the brain uses two strategies to maintain balance and prevent a fall, says Alexander Aruin, professor of physical therapy at University of Illinois at Chicago and principal investigator on the two studies.
A man-made form of insulin delivered by nasal spray may improve working memory and other mental capabilities in adults with mild cognitive impairment and Alzheimer's disease dementia, according to a pilot study led by researchers at Wake Forest Baptist Medical Center.
Each year more than 12 million Americans visit their doctors complaining of headaches, which results in estimates of lost productivity and costs of upwards of $31 billion annually. A new study suggests some of that cost could be offset by physicians ordering fewer tests and an increased focus on counseling about lifestyle changes.
With the cultural spotlight shining so brightly on the risks of gridiron football, it was only a matter of time before the unknown risks of youth rugby got some scrutiny, and a senior doctor in The BMJ does that this week.
Michael Carter, a pediatric neurosurgeon at Bristol Royal Hospital for Children, argues that "rugby sidesteps many safeguards intended to ensure pupil wellbeing" and calls on schools, clubs, medical facilities, and regulatory bodies to "cooperate now to quantify the risks of junior rugby."
Scientists have long known that species such as amphibians and fish can regenerate retinal cells — so why can’t mammals? The third report from the Albert and Mary Lasker Foundation and the International Retinal Research Foundation’s 10-year collaboration, recently published in Translational Vision Science & Technology (TVST), addresses this and other questions.
Noninvasive brain scans, such as functional magnetic resonance imaging, have led to basic science discoveries about the human brain, but they've had only limited impacts on people's day-to-day lives. A review article published in the January 7 issue of the Cell Press journal Neuron, however, highlights a number of recent studies showing that brain imaging can help predict an individual's future learning, criminality, health-related behaviors, and response to drug or behavioral treatments. The technology may offer opportunities to personalize educational and clinical practices.
DNA sequences were once thought to be identical from cell to cell but it's increasingly understood that mutations can arise during brain development that affect only certain groups of brain cells.
A technique developed at Boston Children's Hospital allows these subtle mutation patterns to be traced and mapped spatially for the first time. This capability is a significant advance for genetics research and provides a new way to study both the normal brain and brain disorders such as epilepsy and autism.
It's normal for cognitive function to slightly deteriorate with age. Memory capacity begins to worsen, along with processing speed and the ability to form long-term memories. Finding a way to defer the onset of these issues becomes increasingly important as life expectancy gets longer and global populations age.