Brain

Research by Dr. Shernaz Bamji, from the University of British Columbia, uncovers the mechanism of action of an enzyme called DHHC9 in the normal development and function of neural networks in the brain. Mutations in DHHC9 have been identified in certain patients suffering from X-linked Intellectual Disability, however the specific role of DHHC9 was not known. Dr.

A team of scientists from across the globe have shown that the brains of patients with schizophrenia have the capacity to reorganize and fight the illness. This is the first time that imaging data has been used to show that our brains may have the ability to reverse the effects of schizophrenia.

Schizophrenia is an illness generally associated with a widespread reduction in brain tissue volume. However, a recent study found that a subtle increase in tissue also occurs in certain brain regions.

ANN ARBOR--It happens in many households. Kids are tapping on their cell phones or are preoccupied by their favorite TV show as their parents ask them a question or want them to do a chore.

It's not just teens caught up in electronic media, but also preschoolers. In fact, there is little mother-child dialogue or conversation while children ages 3 to 5 are using media, such as TV, video games and mobile devices, according to a new University of Michigan study.

Babies find it easier to learn words with repetitive syllables rather than mixed sounds, a study suggests.

Assessments of language learning in 18-month-olds suggest that children are better at grasping the names of objects with repeated syllables, over words with non-identical syllables.

Researchers say the study may help explain why some words or phrases, such as 'train' and 'good night', have given rise to versions with repeated syllables, such as choo-choo and night-night.

Prion diseases are fatal and incurable neurodegenerative conditions of humans and animals. Yet, how prions kill nerve cells (or neurons) remains unclear. A study published on May 26, 2016 in PLOS Pathogens describes a system in which to study the early assault by prions on brain cells of the infected host.

Research led by the Achucarro Basque Center for Neuroscience, the University of the Basque Country (UPV/EHU), and the Ikerbasque Foundation has revealed the mechanisms that keep the brain clean during neurodegenerative diseases.

The precise diagnosis and prognosis of recovery of consciousness of patients after a severe brain injury is a challenging clinical task, as some brain-injured patients retain certain levels of awareness despite appearing fully unresponsive. Now, researchers reporting in the Cell Press journal Current Biology on May 26 have evidence that readily obtainable measures of the amount of glucose (sugar) consumed by the brain can directly predict a person's current level of awareness, or the likelihood that they will recover awareness within a year.

Smell in mammals turns out to be more complex than we thought. Rather than one receptor family exclusively dedicated to detecting odors, a study in mice reports that a group of neurons surrounding the olfactory bulb use an alternative mechanism for catching scents. These "necklace" neurons, as they're called, use this newly discovered olfactory detection system to respond to odors that elicit instinctive responses, such as pheromones and the smell of seeds and nuts. Harvard researchers report the finding May 26 in Cell.

LA JOLLA, CA - May 26, 2016 - A healthy brain has just the right ratio of cells that enhance signals (excitatory neurons) and cells that tone down signals (inhibitory neurons). These two sets of neurons start out looking exactly the same, so what determines their roles?

It is not surprising that a good night's sleep improves our ability to remember what we learned during the day. Now, researchers at the RIKEN Brain Science Institute in Japan have discovered a brain circuit that governs how certain memories are consolidated in the brain during sleep. Published in the May 26 issue of Science magazine, the study shows how experimentally manipulating the identified neural connection during non-REM sleep (deep sleep) can prevent or enhance memory retention in mice.

In our daily lives we constantly have to shift between habitual and goal-directed actions. For example, having to drive to a new place instead of driving home. Difficulties with stopping habits and shifting to goal-directed control underlie a number of neuropsychiatric disorders, including obsessive-compulsive disorder and addiction.

Mammals have an exquisitely tuned sensory system that tells them whether they are smelling an orange or a rose. Like keys on a piano keyboard, each component of an odor blend strikes only one chord of olfactory neuron activation. These chords are combined to form a melody that is "heard" in the brain as distinctly citrusy or sweet and flowery.

Summary:

Deep learning, frequently referred to as artificial intelligence, a branch of machine learning utilizing multiple layers of neurons to model high-level abstractions in data, has outperformed humans in tasks including image, text and voice recognition, autonomous driving and others, and is now being applied to drug discovery and biomarker development.

pic This image shows deep neural networks for drug discovery. Credit: Insilico Medicine, Inc.

The improbable rise of Bernie Sanders' presidential campaign presents an interesting question: why is Sanders, a self-proclaimed "democratic socialist," running as a Democrat? McGill University sociologist Barry Eidlin examines this question through an historical comparison with Canada, a country similar to the U.S. in many ways, but whose political culture and electoral system have ostensibly been more hospitable to labor parties.

WASHINGTON, DC, May 26, 2016 -- The improbable rise of Bernie Sanders' presidential campaign presents an interesting question: why is Sanders, a self-proclaimed "democratic socialist," running as a Democrat? "In any other industrialized country, Sanders would likely be the standard-bearer for a labor or social democratic party," said McGill University sociologist Barry Eidlin, whose new study appears in the June issue of the American Sociological Review. "But the U.S. famously lacks such a party."