Brain | Page 1608 | Science Codex

Fragile X syndrome -- A stimulating environment restores neuronal function in mice

Fragile X syndrome is the most common form of inherited mental retardation, occurring in 1 in 3600 males and 1 in 4000 to 6000 females.

To understand the details of the neuronal pathology of Fragile X syndrome, the researchers studied mice in which the same gene that causes the disease in humans had been knocked out. The scientists performed a detailed analysis of the electrophysiological properties of neurons in the prefrontal cortex, a region responsible for higher cognitive functions, including learning and memory, that are affected in humans with the disorder.

Check and balance for neuron activity provides insight into schizophrenia, seizures

Two genes important for human development and implicated in cancer and schizophrenia also help keep a healthy balance between excitation and inhibition of brain cells, researchers say.

Neuregulin-1 and its receptor, ErbB4, promote inhibition at the site of inhibitory synapses in the brain by increasing release of GABA, a major inhibitory neurotransmitter, Medical College of Georgia researchers led by Dr. Lin Mei report in the May 24 issue of Neuron.

12-month study demonstrated tolerability and efficacy of Daytrana

Shire plc announced that DAYTRANATM (methylphenidate transdermal system), the first and only non-oral medication approved for treatment of Attention Deficit Hyperactivity Disorder (ADHD) in children aged 6 to 12 years, provided significant improvement in symptom control and tolerability, according to results of a 12-month open-label study presented at the American Psychiatric Association (APA) annual meeting in San Diego.

Investigational nonstimulant Guanfacine XR significantly improved ADHD symptoms

Shire plc announced today the positive results of studies of the investigational medication guanfacine extended release (GXR, previously referred to as SPD503), a selective alpha-2A-adrenoceptor agonist. These data from two short-term phase III placebo-controlled studies and two long-term phase III open-label studies, presented at the 2007 American Psychiatric Association (APA) annual meeting, demonstrated that GXR significantly improved all core symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD) in children aged 6 to 17 years.

Adult brain cells rediscover their inner child

You may not be able to relive your youth, but part of your brain can. Johns Hopkins researchers have found that newly made nerves in an adult brain's learning center experience a one-month period when they are just as active as the nerves in a developing child. The study, appearing this week in Neuron, suggests that new adult nerves have a deeper role than simply replacing dead ones.

Long-term treatment with VYVANSE demonstrates significant efficacy in ADHD

Shire plc today announced that VYVANSE™ (lisdexamfetamine dimesylate) effectively controlled Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms in children aged 6 to 12 years. In addition, 95 percent of children taking VYVANSE daily for 12 months showed overall improvement, according to phase III open-label extension trial results. Further analysis of phase II clinical data demonstrated that VYVANSE provided consistent time to maximum concentration of d-amphetamine from patient to patient.

Why girls are afraid to be good at math

A popular stereotype that boys are better at mathematics than girls undermines girls' math performance because it causes worrying that erodes the mental resources needed for problem solving, new research at the University of Chicago shows.

The scholars found that the worrying undermines women's working memory. Working memory is a short-term memory system involved in the control, regulation and active maintenance of limited information needed immediately to deal with problems at hand.

Flaws in colonoscopies may increase risk of colon cancer

Colonoscopies are considered the gold standard for detecting colon cancer, the second leading cause of cancer deaths in the United States. Research presented today at Digestive Disease Week® 2007 (DDW®) discusses contributing factors that could prevent patients from getting optimal results from their colonoscopy, including age of the patient, location of the screening and proper technician training. DDW is the largest international gathering of physicians and researchers in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery.

Research Reveals Clues To Mysteries Of Physical Attractiveness

Score one for body language: It seems that body shape and the way people walk hold major cues to their attractiveness to others, according to collaborative research findings published by Texas A&M University professor Louis G. Tassinary and co-author Kerri Johnson of New York University.

"People have always tried to identify the magical formula for beauty, and we knew body shape was important, but we found movement was also key," Johnson says.

Sexual orientation affects how well you read a map, but age just targets gender

Researchers at the University of Warwick have found that sexual orientation has a real effect on how we perform mental tasks such as navigating with a map in a car but that old age does not discriminate on grounds of sexual orientation and withers all men’s minds alike.

Efficacy and safety of Aripiprazole as adjunctive therapy in major depressive disorder

In adults with major depressive disorder, adding aripiprazole to antidepressant therapy (ADT) resulted in significant improvement in the primary endpoint, the Montgomery-Asberg Depression Rating Scale (MADRS) Total Score.

In this six-week, randomized, placebo-controlled study atypical antipsychotic aripiprazole was added to antidepressants in patients who did not have an adequate response to ADT alone. (1)(Berman, 2007, APA Poster) These findings are from one of two completed studies evaluating adjunctive aripiprazole with ADT.

How does day length affect aggression in mice?

Imagine if a naturally occurring chemical in your body could help make you feel more calm and relaxed – but it would only work during the long days of summer.

The same chemical would, instead, make you aggressive and nasty when you were exposed to less daylight during the winter.

That's exactly what occurs for a specific species of mouse, according to a new study at Ohio State University.

How pure oxygen harms the brain

It's a scenario straight out of Gray's Anatomy – a paramedic or doctor plops a mask over the face of a person struggling to breathe and begins dispensing pure oxygen.

Yet growing research suggests that inhaling straight oxygen can actually harm the brain. For the first time, a new UCLA brain-imaging study reveals why. The findings fly in the face of national guidelines for medical practice and recommend a new approach adding carbon dioxide to the gas mix to preserve brain function in patients.

A glass of wine per day may delay dementia

In people with mild cognitive impairment, up to one drink of alcohol a day may slow their progression to dementia, according to a study published in the May 22, 2007, issue of Neurology®. Mild cognitive impairment is a transitional stage between normal aging and dementia that is used to classify people with mild memory or cognitive problems and no significant disability.

Yoga as possible treatment for depression

Researchers at Boston University School of Medicine (BUSM) and McLean Hospital have found that practicing yoga may elevate brain gamma-aminobutyric (GABA) levels, the brain's primary inhibitory neurotransmitter. The findings suggest that the practice of yoga be explored as a possible treatment for depression and anxiety, disorders associated with low GABA levels.