Individuals with glioblastoma multiforme (GBM), one of the most aggressive types of brain tumor, have an extremely poor prognosis. Although pre-clinical studies indicated therapeutics inhibiting a group of proteins known as receptor tyrosine kinases (RTKs) would likely be beneficial to individuals with GBM, these RTK inhibitors have met with limited clinical success — only a small proportion of patients respond to such treatment and most subsequently relapse after only a short time.
Brain
Endocannabinoids are substances produced by several cells in the body that are very similar to compounds found in cannabis plants. They have been implicated in the development of many effects of a high-fat diet, including many risk factors for type 2 diabetes: obesity, insulin resistance, leptin resistance, and dyslipidemia.
In an animal model of multiple sclerosis (MS), neuroradiologists and neurologists of the University hospitals of Heidelberg and Würzburg have been able to visualize inflammatory tissue damage, most of which had remained unrecognized up to now, with the aid of a new contrast medium, Gadofluorine M, in magnetic resonance imaging. The scientists have published their results in the online edition of the renowned medical journal Brain.
Researchers from UQ's Queensland Brain Institute are set to conduct a world-first trial into the link between prenatal vitamin D levels and schizophrenia prevalence.
Funded by the NHMRC and led by QBI's Dr Darryl Eyles, a team of four researchers will study blood spots taken from newborn babies who have gone on to develop schizophrenia in early adulthood.
"Undeniably, low maternal vitamin D affects the way the brain develops," Dr Eyles said.
CINCINNATI – About 4,000 children in the United States die every year from uncontrolled infections of the body known as septic shock, and researchers are pushing the boundaries of molecular science to find new therapies that can stem the condition. But a simple measure of an immune system protein within 24 hours of being admitted to the hospital for septic shock can predict survival in children, yielding a powerful tool for diagnostics and clinical trials of new septic shock therapies, according to a research team led by Cincinnati Children's Hospital Medical Center in the Aug.
Creatine, a popular nutritional supplement renowned for enhancing athletic performance and muscle strength, does not improve exercise outcomes in patients with chronic obstructive pulmonary disease (COPD), according to a new study. The randomized, placebo-controlled, double-blind study provided the most powerful evidence to date that the effect of creatine (Cr) supplementation was negligible at best among these patients.
COLUMBUS, Ohio – Up to three-quarters of U.S. schools deemed failing based on achievement test scores would receive passing grades if evaluated using a less biased measure, a new study suggests.
Ohio State University researchers developed a new method of measuring school quality based on schools' actual impact on learning – how much faster students learned during the academic year than during summer vacation when they weren't in class.
University of Illinois researchers report this week that chronic exposure to estradiol, the main estrogen in the body, diminishes some cognitive functions. Rats exposed to a steady dose of estradiol were impaired on tasks involving working memory and response inhibition, the researchers found.
Their report appears this week in the journal Behavioral Neuroscience.
ANN ARBOR, Mich. — Pat Phalin learned she had hearing loss at 30, when she volunteered to give hearing tests at her local school. The pupils heard sounds she could not hear.
Her husband Larry, a genealogy enthusiast, saw a pattern in his wife's family history. Her mother, grandfather and great-grandfather had severe hearing loss as adults. One of the Phalins' children had hearing problems before he reached school age.
The Viterbi Algorithm, the elegant 41-year-old logical tool for rapidly eliminating dead end possibilities in data transmission, has a new application to go alongside its ubiquitous daily use in cell phone communications, bioinformatics, speech recognition and many other areas of information technology.
In a recent set of papers two investigators from the University of Southern California school that bears the name of the algorithm's inventor say it can play a key role in quantum communication.
Television commercials are a common method for advertising food products. According to a team of University of Alberta researchers, these food advertisements have a powerful influence on its viewers, especially university students.
NEW YORK - A team of researchers from the Harvard Stem Cell Institute (HSCI) and Columbia University, in a collaboration catalyzed by the Project A.L.S./Jenifer Estess Laboratory for Stem Cell Research, has demonstrated that pluripotent stem cells generated from a patient with ALS (amyotrophic lateral sclerosis) can be directed to differentiate into motor neurons—the very brain cells destroyed by ALS. The results of the team's study appear in today's online issue of Science.
St. Louis, July 31, 2008 — Staying awake slows down our brains, scientists have long recognized. Mental performance is at its peak after sleep but inevitably trends downward throughout the day, and sleep deprivation only worsens these effects.
For the first time, researchers at Washington University School of Medicine in St. Louis have found a way to stop this downward slide. When scientists genetically tweaked a part of the brain involved in learning and memory in fruit flies, the flies were unimpaired even after being deprived of sleep.
Like their human hosts, bacteria need iron to survive and they must obtain that iron from the environment. While humans obtain iron primarily through the food they eat, bacteria have evolved complex and diverse mechanisms to allow them access to iron. A Syracuse University research team led by Robert Doyle, assistant professor of chemistry in The College of Arts and Sciences, discovered that some bacteria are equipped with a gene that enables them to harvest iron from their environment or human host in a unique and energy efficient manner.
Throughout the world, scientists are attempting to recognize and treat schizophrenic disorders at an earlier stage. It is hoped that this will improve the prognosis, which has often been unfavorable.