More than half of all human proteins, as well as many important pharmaceutical agents, are glycoproteins, which means that they contain sugar components. In general, natural glycoproteins do not have a homogeneous sugar component. With modern purification techniques, it is practically impossible to isolate sufficient quantities of homogeneous glycoproteins for systematic biomedical studies. Synthesis in the lab is a good alternative—but also a very complex task.
Brain
COLUMBUS, Ohio – For patients with a particularly aggressive form of skin cancer – malignant melanoma – stress, including that which comes from simply hearing that diagnosis, might amplify the progression of their disease.
But the same new research that infers this also suggests that the use of commonly prescribed blood pressure medicines might slow the development of those tumors and therefore improve these patients' quality of life.
CHICAGO --- Researchers from Northwestern University's Feinberg School of Medicine appear to have reversed the neurological dysfunction of early-stage multiple sclerosis patients by transplanting their own immune stem cells into their bodies and thereby "resetting" their immune systems.
"This is the first time we have turned the tide on this disease," said principal investigator Richard Burt, M.D. chief of immunotherapy for autoimmune diseases at the Feinberg School. The clinical trial was performed at Northwestern Memorial Hospital where Burt holds the same title.
BLOOMINGTON, Ind. -- When it comes to assessing the romantic playing field -- who might be interested in whom -- men and women were shown to be equally good at gauging men's interest during an Indiana University study involving speed dating -- and equally bad at judging women's interest.
Researchers expected women to have a leg up in judging romantic interest, because theoretically they have more to lose from a bad relationship, but no such edge was found.
CHICAGO --- Researchers from Northwestern University's Feinberg School of Medicine appear to have reversed the neurological dysfunction of early-stage multiple sclerosis patients by transplanting their own immune stem cells into their bodies and thereby "resetting" their immune systems.
"This is the first time we have turned the tide on this disease," said principal investigator Richard Burt, M.D. chief of immunotherapy for autoimmune diseases at the Feinberg School. The clinical trial was performed at Northwestern Memorial Hospital where Burt holds the same title.
AMES, Iowa – Alexander Stoytchev and his three graduate students recently presented one of their robot's long and shiny arms to a visitor.
Here, they said, swing it around.
And so that visitor tentatively gave the robot's left arm a few twists and twirls. The metal arm was heavy, but still moved easily at its shoulder, elbow and wrist joints.
Then the graduate students hit some keyboard commands and the robot replayed those exact arm movements.
Scientists have known for more than 200 years that vision begins with a series of chemical reactions when light strikes the retina, but the specific chemical processes have largely been a mystery. A team of researchers from the United States and Switzerland, have she new light on this process by "capturing" this chemical communication for future study.
CAMBRIDGE, Mass.--People with Parkinson's disease commonly suffer a slowing or freezing of movement caused by the death of neurons that make dopamine, a key chemical that allows brain cells to send and receive messages essential to voluntary movements. Patients regain the ability to move, seemingly miraculously, by taking L-DOPA or related drugs that mimic the missing dopamine. After a few years on L-DOPA, however, most patients again lose motor control — but in an opposite way.
COLUMBUS, Ohio -- A study of college freshmen in the United States and in China found that Chinese students know more science facts than their American counterparts -- but both groups are nearly identical when it comes to their ability to do scientific reasoning.
Neither group is especially skilled at reasoning, however, and the study suggests that educators must go beyond teaching science facts if they hope to boost students' reasoning ability.
Scientists have uncovered the underlying biological reason why locusts form migrating swarms. Their findings, reported in today's edition of Science, could be used in the future to prevent the plagues which devastate crops (notably in developing countries), affecting the livelihood of one in ten people across the globe.
Neurobiologists at Washington University School of Medicine in St. Louis have identified pathways that allow microscopic worms to survive in a low-oxygen, or hypoxic, environment.
They believe the finding could have implications for conditions such as stroke, heart attack and cancer. Sensitivity to low oxygen helps determine how damaging those medical conditions can be. The researchers report their findings in the Jan. 30 issue of the journal Science.
LA JOLLA, CA—How are neurodegenerative diseases such as Alzheimer's initiated, and why is age the major risk factor? A recent study of a protein called MOCA (Modifier of Cell Adhesion), carried out at the Salk Institute for Biological Studies, provides new clues to the answers of these fundamental questions.
(New York, NY) – Calling this period "an unparalleled opportunity" for change, an influential group of medical leaders today urged the nation's medical schools to reform their educational model because it too often fails to give new physicians the right mix of competencies and experiences to practice medicine effectively. The call to action for education reform comes as medical schools are expanding their enrollments for the first time in 30 years to address a shortage of physicians in the United States. In a new report, sponsored by the Josiah Macy, Jr.
TALLAHASSEE, Fla. -- Teenagers who smoke could be setting themselves up for depression later in life, according to a groundbreaking new Florida State University study.
Psychology Professor Carlos Bolanos and a team of researchers found that nicotine given to adolescent rats induced a depression-like state characterized by a lack of pleasure and heightened sensitivity to stress in their adult lives. The findings, published online in the journal Neuropsychopharmacology, suggest that the same may be true for humans.
Milan, Italy, 29 January 2009 - In a new fMRI study conducted in the Epidemiology, Biostatistics and Clinical Research Laboratory (Montpellier I University, France) and published by Elsevier in the February 2009 issue of Cortex (http://www.elsevier.com/locate/cortex), researchers found differences among male and female groups on activation strength linked to verbal fluency (words generation).