New research finds that a complex interaction between separate factors underlies the pathology associated with Parkinson's disease (PD), reinforcing the concept that multiple therapeutic targets should be considered when designing treatment strategies. The findings, published by Cell Press in the April 30th issue of the journal Neuron, also help to explain why known risk factors do not predict PD in a straightforward manner.
Brain
Washington, DC – Neuroscientists at Georgetown University Medical Center have found that an area known to be important for reading in the left visual cortex contains neurons that are specialized to process written words as whole word units. Although some theories of reading as well as neuropsychological and experimental data have argued for the existence of a neural representation for whole written real words (an "orthographic lexicon"), evidence for this has been elusive.
Human beings far outpace computers in their ability to recognize faces and other objects, handling with ease variations in size, color, orientation, lighting conditions and other factors. But how our brains handle this visual processing isn't known in much detail. Researchers at Children's Hospital Boston, taking advantage of brain mapping in patients about to undergo surgery for epilepsy, demonstrate for the first time that the brain, at a very early processing stage, can recognize objects under a variety of conditions very rapidly.
Philadelphia, PA, April 29, 2009 – Relationships are difficult and most of us probably think at some point that communicating positively with our partner when discussing stressful issues, like home finances, is an impossible task. What if there was a safe way to take the "edge" off these discussions? The biology of human social relationships is just beginning to emerge as groundbreaking research on social cognition conducted in animals is now informing research in humans.
Philadelphia, PA, April 29, 2009 – A growing body of basic animal research and studies of abused and neglected children provide a strong basis of support for the hypothesis that individuals with particular genotypes are at greater risk for depression, anxiety disorders, and problems with the abuse of alcohol and other substances. These gene-by-environment interactions are so powerful that some might assume that these genotypes identify people who are predestined to negative life outcomes.
The human brain stores some kinds of memories for a lifetime. But when our eyes are open and looking at things, our gray matter also creates temporary memories that help us process complex tasks during the few seconds these visual memories exist. For decades, scientists have held that such short-term memories don't suddenly disappear, but grow gradually more imprecise over the course of several seconds.
More than 10 million U.S. children witness domestic violence yearly, resulting in a range of emotional and behavioral problems. A new study suggests that the reason some of these children are resilient is because of their easy temperaments and because they have mentally healthy moms.
The longitudinal study, conducted by researchers at Michigan State University, is published in the March/April 2009 issue of the journal Child Development.
A three-year study of African American youths' perceptions of racial discrimination has found that many Black teens consider themselves victims of racial discrimination, and these perceptions are linked to how they feel about being Black, particularly their views of how the broader society sees African Americans.
The study, by researchers at the University of North Carolina at Chapel Hill, Fordham University, and the University of Michigan, can be found in the March/April 2009 issue of the journal Child Development.
Addictive behaviour is determined by conscious, rapid thought processes, not necessarily by the content of visual stimuli as previously thought according to research funded by the Biotechnology and Biological Sciences Research Council (BBSRC).
An acid-sensitive protein in the brain may represent a new target for the treatment of depression, according to animal research in the April 29 issue of The Journal of Neuroscience. The study shows that disrupting acid-sensitive ion channel-1a (ASIC1a) produces antidepressant-like effects in mice. The findings may one day benefit people who do not respond to traditional antidepressants or who cannot tolerate their side effects.
A brain protein involved in fear behavior and anxiety may represent a new target for depression therapies, according to a study by researchers at the University of Iowa and the Iowa City Veterans Affairs Medical Center. The results appear in the April 29 issue of the Journal of Neuroscience.
Facial recognition is not as automatic as it may seem. Researchers have identified specific areas in the brain devoted solely to picking out faces among other objects we encounter. Two specific effects have been established as being critical for facial recognition – holistic processing (in which we view the face as a whole, instead of in various parts) and left-side bias (in which we have a preference for the left side of the face). Psychologists Janet H. Hsiao from the University of Hong Kong and Garrison W.
UCLA scientists, in partnership with 30 research institutions across the country, have identified a new gene variant that is highly common in autistic children. And when researchers scrutinized the activity of the gene, known as CDH10, in the fetal brain, they discovered that it is most active in key regions that support language, speech and interpreting social behavior.
A research team has connected more of the intricate pieces of the autism puzzle, with two studies that identify genes with important contributions to the disorder. One study pinpoints a gene region that may account for as many as 15 percent of autism cases, while another study identifies missing or duplicated stretches of DNA along two crucial gene pathways. Significantly, both studies detected genes implicated in the development of brain circuitry in early childhood.
Stroke victims tend to do worse if they also have diagnosed or undiagnosed obstructive sleep apnea prior to having the stroke, according to a study presented April 28, 2009, at the American Academy of Neurology (AAN) annual meeting in Seattle.
Latha Stead, M.D., professor and chair of the Department of Emergency Medicine at the University of Rochester Medical Center, and professor of Neurosurgery, reported the findings at AAN, along with several other stroke studies measuring the factors that lead to a poor prognosis.