Brain

Immune cells known as microglia, long thought to be activated in the brain only when fighting infection or injury, are constantly active and likely play a central role in one of the most basic, central phenomena in the brain – the creation and elimination of synapses.

The nature-nurture debate is a "giant step" closer to being resolved after scientists studying bees documented how environmental inputs can modify our genetic hardware.

Immune cells known as microglia, long thought to be activated in the brain only when fighting infection or injury, are constantly active and likely play a central role in one of the most basic, central phenomena in the brain – the creation and elimination of synapses. The findings, publishing next week in the online, open access journal PLoS Biology, catapult the humble microglia cell from its well-recognized duty of protecting the brain to direct involvement in creating the cellular networks at the core of brain behavior.

A University of Toronto study shows that visual attention -- the brain's ability to selectively filter unattended or unwanted information from reaching awareness -- diminishes with age, leaving older adults less capable of filtering out distracting or irrelevant information.

Turns out the high school guidance counselor was right. Students who have high aspirations and put thought into their futures during their high school years tend to reach higher levels of educational attainment, according to a recent study.

And what's a significant factor in those goals and expectations taking shape in the first place? It matters if teens are involved in extracurricular activities -- whether it's football, fine arts or French club.

Mouse model confirms mutated protein's role in dementia

A team of scientists from Japan and the University of California, San Diego School of Medicine have created a new mouse model that confirms that mutations of a protein called beta-synuclein promote neurodegeneration. The discovery creates a potential new target for developing treatments of diseases like Parkinson's and Alzheimer's.

Gastric bypass surgery decreases the preference for sweet-tasting substances in obese rats, a study finding that could help in developing safer treatments for the morbidly obese, according to Penn State College of Medicine researchers.

"Roux-en-Y gastric bypass surgery is the most common effective treatment for morbid obesity," said Andras Hajnal, M.D., Ph.D., associate professor, Department of Neural and Behavioral Science and Surgery. "Many patients report altered taste preferences after having the procedure."

WEST LAFAYETTE, Ind. - Researchers have learned the structure that results when an antibody binds to the West Nile virus, neutralizing the virus by locking up its infection mechanism. The information could help scientists develop a vaccine against the mosquito-borne disease.

Winston-Salem, N.C. – Researchers for the first time have shown that drinking beet juice can increase blood flow to the brain in older adults – a finding that could hold great potential for combating the progression of dementia.

The research findings are available online in Nitric Oxide: Biology and Chemistry, the peer-reviewed journal of the Nitric Oxide Society and will be available in print soon. (Read the abstract.)

NJIT Associate Professor Victor Matveev, PhD, in the department of mathematical sciences, was part of a research team that published "N-type Ca2+ channels carry the largest current: Implications for nanodomains and transmitter release," in Nature Neuroscience on Oct. 17, 2010. http://www.nature.com/neuro/journal/v13/n11/abs/nn.2657.html

Patients with mild to moderate Alzheimer's disease (AD) who received supplementation with the omega-3 fatty acid docosahexaenoic acid (DHA), believed to possibly reduce the risk of AD, did not experience a reduction in the rate of cognitive and functional decline, compared to patients who received placebo, according to a study in the November 3 issue of JAMA, a theme issue on aging.

 Health care delivery model yields improved outcomes and lower costs

INDIANAPOLIS – A model program developed at Indiana University to provide care to low-income older adults in their homes has earned recognition for its effective approach and cost-saving benefits in a leading national medical journal.

Researchers at the Swedish medical university Karolinska Institutet have shown that they may be able to monitor the aging process in the brain, by using MRI technique to measure the brain lactic acid levels. Their findings suggest that the lactate levels increase in advance of other aging symptoms, and therefore could be used as an indicator of aging and age-related diseases of the CNS.

A pre-school language intervention programme can significantly improve the educational lives of children with poorly developed speech and language skills, according to new research by psychologists at the University of York.

In the Language 4 Reading project, a team from the University's Department of Psychology at the University of York have evaluated the benefits of a pre-school language intervention programme for children who enter school with poorly developed speech and language skills.

Brain damage continues to develop and evolve for months after a traumatic brain injury (TBI), revealing a potential target for treatments to improve brain trauma, new research led by the University of Melbourne, Australia has found.

The study funded by the Victorian Neurotrauma Initiative is published in the latest issue of The Journal of Nuclear Medicine (JNM).