A new study offers critical insight into the biochemistry of a rare and fatal form of epilepsy known as Lafora disease, a genetic condition that typically strikes children in their teens. The disease is characterized by the buildup of a "wrecked" form of glycogen, a stored form of glucose, in the brain and specifically in neurons. It now appears those errors and the structural problems they cause are all because the enzyme that normally builds glycogen is prone to making mistakes, according to the report in Cell Metabolism.
Brain
DALLAS – March 1, 2011 – Researchers at UT Southwestern Medical Center have identified a signaling pathway in the brain that's sufficient to induce cellular leptin resistance, a problem that decreases the body's ability to "hear" that it is full and should stop eating.
CHAMPAIGN, lll. — A review of more than 160 studies of human and animal subjects has found "clear and compelling evidence" that – all else being equal – happy people tend to live longer and experience better health than their unhappy peers.
Scientists have discovered a new way to generate human motor nerve cells in a development that will help research into motor neurone disease.
A team from the Universities of Edinburgh, Cambridge and Cardiff has created a range of motor neurons – nerves cells that send messages from the brain and spine to other parts of the body – from human embryonic stem cells in the laboratory.
Despite substantial gains in knowledge and understanding of autism over the last three years, we are still no closer to either prevention or cure, according to Sir Michael Rutter, Professor of Developmental Psychopathology at the Institute of Psychiatry, King's College London. In a new study, Rutter reviews the latest scientific developments in the study of autism, published between 2007-2010. His paper is available online in Springer's Journal of Autism and Developmental Disorders. Professor Rutter is the first consultant of child psychiatry in the United Kingdom.
The more honesty and humility an employee may have, the higher their job performance, as rated by the employees' supervisor. That's the new finding from a Baylor University study that found the honesty-humility personality trait was a unique predictor of job performance.
Robotic surgery offers the same or better results than minimally invasive laparoscopic procedures for treating kidney disease, and can potentially help more patients because it is not as difficult for surgeons to learn, according to a new study led by Henry Ford Hospital specialists.
The findings come at a time both when chronic kidney disease is becoming more common, and while occult – or hidden – damage to kidney function has been overlooked in more than a fourth of patients with small kidney tumors, according to earlier studies.
Montreal, March 1, 2011 – Although Edith Piaf defiantly sang, "Non, je ne regrette rien," most people will have their share of regrets over their lifetime. Indeed, anyone who seeks to overcome disappointments should compare themselves to others who are worse off – rather than looking up to folks in more enviable positions – according to a new study from Concordia University. Published in the journal Personality and Social Psychology Bulletin, these findings have implications for both young and old.
Minneapolis/St. Paul (Mar. 1, 2011) – A five-year clinical trial led by University of Minnesota Medical School researchers has led to a new method of cardiopulmonary resuscitation (CPR) that improves long-term survival rates with good brain function by 50 percent.
University Park, Pa. -- Free time is not always a fun time for people with autism. Giving them the power to choose their own leisure activities during free time, however, can boost their enjoyment, as well as improve communication and social skills, according to an international team of researchers.
New research on the genomics of autism confirms that the genetic roots of the disorder are highly complicated, but that common biological themes underlie this complexity. In the current study, researchers have implicated several new candidate genes and genomic variants as contributors to autism, and conclude that many more remain to be discovered. While the gene alterations are individually very rare, they mostly appear to disrupt genes that play important functional roles in brain development and nerve signaling.
Researchers at Karolinska Institutet have shown in a new study on mice, that cell therapy can be used to reverse the effect of 'bad' LDL cholesterol and reduce the inflammation that leads to atherosclerosis. The new cell therapy, which is presented in the prestigious scientific journal Circulation, can open the way for new therapies for stroke and myocardial infarction if the results prove translatable to humans.
Low self-esteem is associated with a greater risk of mental health problems such as eating disorders and depression. From a public health perspective, it is important for staff in various health-related professions to know about self-esteem. However, there is a vast difference between the research-based knowledge on self-esteem and the simplified popular psychology theories that are disseminated through books and motivational talks, reveals research from the University of Gothenburg.
DARIEN, IL – A new study in the March 1 issue of the journal Sleep indicates that the ability of children with attention deficit hyperactivity disorder to remain vigilant and attentive deteriorated significantly after losing less than one hour of nightly sleep for a week. The study suggests that even moderate reductions in sleep duration can affect neurobehavioral functioning, which may have a negative impact on the academic performance of children with ADHD.
Emory University experts predict that rates of depressive disorders among men will increase as the 21st century progresses.
In an editorial published in the March, 2011 issue of the British Journal of Psychiatry http://bjp.rcpsych.org/, author Boadie Dunlop, MD, writes "Compared to women, many men attach a great importance to their roles as providers and protectors of their families. Failure to fulfill the role of breadwinner is associated with greater depression and marital conflict."