Body
(Friday, February 12, 2021 - Toronto) -- Inhibiting a key enzyme that controls a large network of proteins important in cell division and growth paves the way for a new class of drugs that could stop glioblastoma, a deadly brain cancer, from growing.
Researchers at Princess Margaret Cancer Centre, the Hospital for Sick Children (SickKids) and University of Toronto, showed that chemically inhibiting the enzyme PRMT5 can suppress the growth of glioblastoma cells.
Peer-reviewed / Review, Survey and Opinion piece
To ensure an effective global immunisation strategy against COVID-19, vaccines need to be produced at scale, priced affordably, and allocated globally so that they are available where needed, and successfully rolled out.
Review of evidence includes a comparison of 26 leading vaccines on their potential contribution to achieving global vaccine immunity, and a new survey of COVID-19 vaccine confidence in 32 countries.
Osteoporosis is a leading global health challenge. Besides its own adverse effects, it also impairs the function of bone implants - normally made of a metal called titanium (Ti). Because there is less bone than normal in the implantation site, the implants could easily loosen, and persistent inflammation often accompanies.
The drug thalidomide was sold as a sedative under the trade name Contergan in the 1950s and 1960s. At the time, its side-effects triggered one of the largest pharmaceutical scandals in history: The medication was taken from the market after it became known that the use of Contergan during pregnancy had resulted in over 10,000 cases of severe birth defects.
A new study from Washington University School of Medicine in St. Louis demonstrates that a liquid biopsy examining blood or urine can help gauge the effectiveness of therapy for colorectal cancer that has just begun to spread beyond the original tumor. Such a biopsy can detect lingering disease and could serve as a guide for deciding whether a patient should undergo further treatments due to some tumor cells evading an initial attempt to eradicate the cancer.
Masks help protect the people wearing them from getting or spreading SARS-CoV-2, the virus that causes COVID-19, but now researchers from the National Institutes of Health have added evidence for yet another potential benefit for wearers: The humidity created inside the mask may help combat respiratory diseases such as COVID-19.
A new study published in CMAJ (Canadian Medical Association Journal) found that the risk of death from COVID-19 was 3.5 times higher than from influenza.
Individual choices in medicine carry a certain amount of uncertainty.
An innovative partnership at The University of Texas at Austin takes aim at medicine down to the individual level by applying state-of-the-art computation to medical care.
"Medicine in its essence is decision-making under uncertainty, decisions about tests and treatments," said Radek Bukowski, MD, PhD, professor and associate chair of Investigation and Discovery in the Department of Women's Health at Dell Medical School at UT Austin.
New Rochelle, NY, February 10, 2021--It may be safe for COVID-infected mothers to maintain contact with their babies. Keeping them apart can cause maternal distress and have a negative effect on exclusive breastfeeding later in infancy, according to The COVID Mothers Study published in the peer-reviewed journal Breastfeeding Medicine. Click here to read the article now.
Peer reviewed / Review and opinion
First comprehensive assessment of damage to health inflicted by former President Trump cites decades of policy failures made worse by the Trump administration, resulting in 461,000 unnecessary US deaths annually before the COVID-19 pandemic, and tens of thousands of unnecessary COVID-19 and pollution-related deaths attributable to his actions.
Washington, DC - February 9, 2021 - A team of investigators from the Republic of China has discovered that 6 drugs previously approved by the US Food and Drug Administration (FDA) for other indications could be repurposed to treat or prevent COVID-19. The research is published in Antimicrobial Agents and Chemotherapy, a journal of the American Society for Microbiology.
Using FDA-approved drugs saves time -- the drugs don't need to go through the FDA approval process again -- making them available quickly to treat patients who need them.
DALLAS, Feb. 10, 2021 — Reducing the prevalence of obesity may prevent up to half of new Type 2 diabetes cases in the United States, according to new research published today in the Journal of the American Heart Association, an open access journal of the American Heart Association. Obesity is a major contributor to diabetes, and the new study suggests more tailored efforts are needed to reduce the incidence of obesity-related diabetes.
Increased level of plasma cells linked to improved cancer survival
1,300 prostate tumor samples studied
Immunotherapy-based precision medicine clinical trials being developed
ANN ARBOR, Mich. and VANCOUVER, B.C. (February 10, 2021) - After screening more than 1,100 independently assessed, point-of-care COVID-19 tests, researchers at NSF International and Novateur Ventures have identified 5 direct (antigen/RNA) tests for detection of acute infection and 6 indirect (antibody) tests for detection of prior infection that meet the recently published World Health Organization (WHO) "desirable" Target Product Profile (TPP) criteria.