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Approximately 15-to-30 percent of patients with metastatic breast cancer have brain metastasis (BM), with basal-like breast cancer (BLBC) metastasizing to the brain most frequently. The prognosis for BLBC-BM patients is poor, as the blood-brain barrier prevents most therapeutics from reaching the brain. Testing candidate therapies in clinical trials is also challenging because animal models that mimic BM are limited.
Beijing, 26 February 2021: the journal Cardiovascular Innovations and Applications (CVIA) has just published the third issue of Volume 5. This issue brings together important research from authors in the USA and China, including several important papers concerned with the various cardiological implications of COVID-19.
Papers in the issue are as follows.
RESEARCH PAPERS
A new review of existing evidence proposes eight hallmarks of environmental exposures that chart the biological pathways through which pollutants contribute to disease: oxidative stress and inflammation, genomic alterations and mutations, epigenetic alterations, mitochondrial dysfunction, endocrine disruption, altered intercellular communication, altered microbiome communities, and impaired nervous system function.
Scientists at Walter Reed Army Institute of Research, in a collaboration with Duke University, have confirmed that monoclonal antibodies can be an effective tool in the global fight against malaria.
If you are going to buy a face mask to protect yourself and others from COVID-19, make sure it's a three-layered mask. You might have already heard this recommendation, but researchers have now found an additional reason why three-layered masks are safer than single or double-layered alternatives.
Mount Sinai Researchers find a new way to prevent attention deficits associated with Fragile X, a leading genetic cause of autism, in an animal model
Corresponding Author: Hirofumi Morishita, MD, PhD, Department of Psychiatry, Neuroscience, Friedman Brain Institute, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York.
BUFFALO, N.Y. - New research using a nationally representative sample of more than 12,000 participants shows the collateral consequences victims are likely to confront following unfair treatment by police.
Michael Brown, George Floyd and Tamir Rice are just some of those who have died recently at the hands of police.
Strong, collaborative relationships with principal investigators are a key factor of longevity in clinical research coordinator positions -- an essential, but increasingly transient job in executing treatment-advancing clinical trials, Vanderbilt University Medical Center researchers found.
With three out of four newly emerging infectious human diseases originating in animals*, there is an urgent need to monitor the legal trade in wildlife, according to new research by Vincent Nijman, Professor in Anthropology at Oxford Brookes University.
Administering zinc supplements to covid-19 patients with low levels of this element may be a strategy to reduce mortality and recovery time. At the same time, it could help to prevent risk groups, like the elderly, from suffering the worst effects of the disease. These are the findings of a study by physicians and researchers from the Hospital del Mar, Hospital del Mar Medical Research Institute (IMIM) and Pompeu Fabra University (UPF), led by Dr. Robert Güerri, a physician at the Infectious Diseases Service of Hospital del Mar, which has just been published in the journal Nutrients.
A recent study outlines a range of privacy concerns related to the programs that users interact with when using Amazon's voice-activated assistant, Alexa. Issues range from misleading privacy policies to the ability of third-parties to change the code of their programs after receiving Amazon approval.
Forager ants do it, vampire bats do it, guppies do it, and mandrills do it. Long before humans learned about and started "social distancing due to COVID-19," animals in nature intuitively practiced social distancing when one of their own became sick.
Cervical cancer is a serious global health threat which kills more than 300,000 women every year. It's a disease that disproportionately affects women in low- and middle-income countries in equatorial Africa, Latin America and Southeast Asia, yet it is a preventable disease and decades of research have produced the tools needed to eliminate it.
Amsterdam, March 4, 2021 - Cervical cancer is a serious global health threat which kills more than 300,000 women every year. It's a disease that disproportionately affects women in low- and middle-income countries in equatorial Africa, Latin America and Southeast Asia, yet it is a preventable disease and decades of research have produced the tools needed to eliminate it.
WASHINGTON (March 4, 2021)--Over the next month, 209 U.S. counties in the United States will need to implement crisis workforce strategies to deal with potentially dangerous shortfalls of intensive care unit doctors, according to a new analysis published today. The analysis draws on data from a just launched county-level hospital workforce estimator, one that takes into account the strain on staffing due to the COVID-19 pandemic.