Body
(Philadelphia, PA) - About 6.2 million Americans suffer from heart failure, an incurable disease with a staggering mortality rate - some 40 percent of patients die within five years of diagnosis. Heart failure is one form of heart disease, for which new therapies are desperately needed.
ITHACA, N.Y. - A new Penn State and Cornell study describes an effort to produce the most comprehensive and high-resolution map yet of chromosome architecture and gene regulation in yeast, a major step toward improving understanding of development, evolution and environmental responses in higher organisms.
Specifically, the study mapped precise binding sites of more than 400 different chromosomal proteins in the yeast genome, most of which regulate the expression of genes.
WINSTON-SALEM, NC - March 12, 2021 - The Wake Forest Institute for Regenerative Medicine is investigating how cats with chronic kidney disease could someday help inform treatment for humans.
Leesburg, VA, March 12, 2021--According to an open-access article in ARRS' American Journal of Roentgenology (AJR), compared with multi-target stool-DNA (mt-sDNA) and fecal immunochemical test (FIT), CT colonography (CTC) with 10 mm threshold most effectively targets advanced neoplasia (AN)--preserving detection while decreasing unnecessary colonoscopies.
Astronomers have painted their best picture yet of an RV Tauri variable, a rare type of stellar binary where two stars - one approaching the end of its life - orbit within a sprawling disk of dust. Their 130-year dataset spans the widest range of light yet collected for one of these systems, from radio to X-rays.
DALLAS, March 11, 2021 — The ongoing U.S.
Patients suffering from dry eye disease symptoms have a lower quality of life compared to those without symptoms, a new study reports. The findings showed that patients with the condition reported negative effects on visual function, their ability to carry out daily activities and their work productivity.
Atherosclerosis is the underlying condition that causes heart attacks and strokes. Researchers at Radboudumc in the Netherlands have discovered a protein that appears to play an important role in atherosclerosis. The protein is called Prosaposin, and its role in atherosclerosis was sofar unknown. "We identified Prosaposin as a new potential target for the Science Translational Medicine.
What The Study Did: In this phase 1 study, a single immunization with Ad26.COV2.S (Janssen/Johnson & Johnson) vaccine induced rapid binding and neutralization antibody responses as well as cellular immune responses. Two phase 3 clinical trials are currently underway to determine the efficacy of the Ad26.COV2.S vaccine.
Authors: Dan H. Barouch, M.D., Ph.D., of Beth Israel Deaconess Medical Center in Boston, is the corresponding author.
Breast cancer is harmful enough on its own, but when cancer cells start to metastasize -- or spread into the body from their original location -- the disease becomes even more fatal and difficult to treat.
Thanks to new research published in Oncogene from the lab of University of Colorado Cancer Center associate director of basic research Heide Ford, PhD, in collaboration with Michael Lewis, PhD, from Baylor College of Medicine, doctors may soon have a better understanding of one mechanism by which metastasis happens, and of potential ways to slow it down.
The global battle against antibiotic resistance can only succeed if local contexts are taken into account. "A tailored approach is needed in each country," says Heiman Wertheim of Radboud university medical center. "There is no "one-size-fits-all' solution." This was the main finding of a study on antibiotic resistance in African and Asian countries funded by the British Wellcome Trust. Wertheim is the lead investigator of a large group of international researchers who recently published an article on this study in The Lancet Global Health.
Black women have 80% higher risk of preterm birth between 32 and 33 weeks of pregnancy if a Black person who lives in their neighborhood is killed by police during the pregnancy, according to a study by researchers at UC San Francisco and UC Berkeley.
When the body detects a pathogen, such as bacteria or viruses, it mounts an immune system response to fight this invader. In some people, the immune system overreacts, resulting in an overactive immune response that causes the body to injure itself, which may prove fatal in some cases.
Now, scientists from Nanyang Technological University, Singapore (NTU Singapore) have created a compound that could help to reduce this overactivation without impairing the body's entire immune response.
The Telomeres and Telomerase Group led by Maria A. Blasco at the Spanish National Cancer Research Centre (CNIO) continues to make progress in unravelling the role that telomeres -the ends of chromosomes that are responsible for cellular ageing as they shorten- play in cancer. The CNIO team was among the first to propose that shelterins, proteins that wrap around telomeres and act as a protective shield, might be therapeutic targets for cancer treatment.
Aspirin is an established, safe, and low-cost medication in long-standing common use in prevention and treatment of cardiovascular diseases, and in the past a pain relief and fever reducing medication. The use of aspirin was very popular during the 1918 Spanish Influenza pandemic, several decades before in-vitro confirmation of its activity against RNA viruses. Studies showed that aspirin, in addition to its well-known anti-inflammatory effects, could modulate the innate and adaptive immune responses helping the human immune system battle some viral infections.