Body
WASHINGTON--A new once-weekly basal insulin injection demonstrated similar efficacy and safety and a lower rate of low blood sugar episodes compared with a daily basal insulin, according to a phase 2 clinical trial. The study results, which will be presented at ENDO 2021, the Endocrine Society's annual meeting, compared an investigational drug called basal insulin Fc (BIF) with insulin degludec, a commercially available long-lasting daily insulin, in patients with type 2 diabetes.
Although cancers that occur in the gallbladder or bile ducts are rare, their rates are increasing. A recent study provides details on the burden of gallbladder and biliary tract cancer (GBTC) across 195 countries and territories from 1990 to 2017. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society.
WASHINGTON--Some patients with moderate to severe COVID-19 disease seem to experience inflammation of the thyroid gland that is different from thyroid inflammation caused by other viruses, according to a study presented virtually at ENDO 2021, the Endocrine Society's annual meeting.
One-third of the study participants still had signs of thyroid inflammation after three months, even though their thyroid function had normalized. The study is following patients to determine whether this inflammation will trigger permanent thyroid dysfunction.
WASHINGTON--Treatment of hypothyroidism, which results from an underactive thyroid gland, should be individualized and consideration should be given to alternatives to the first-line therapy, including desiccated thyroid extract and combination therapy to replace the body's two main thyroid hormones, thyroxine (T4) and triiodothyronine (T3). Results of their new randomized clinical study are being presented at ENDO 2021, the Endocrine Society's annual meeting.
WASHINGTON--New genetic research suggests men can develop characteristics of polycystic ovary syndrome (PCOS)--a common metabolic and reproductive disorder that affects women. The study was presented virtually at ENDO 2021, the Endocrine Society's annual meeting.
PCOS is a common disorder characterized by irregular menstrual periods, disruption of normal metabolism and elevated testosterone levels. PCOS affects up to 10% of all women of reproductive age. The disorder can lead to obesity, diabetes and cardiovascular disease, which are often life-long conditions.
WASHINGTON--A study in mice finds treatment with a molecule called MCB-613 repairs heart tissue after a severe heart attack, preventing damage that can lead to heart failure. The findings are being presented virtually at ENDO 2021, the Endocrine Society's annual meeting.
"This is a remarkable discovery that may lead to effective and safe treatments to prevent the progression to heart failure after a heart attack," said lead researcher Lisa K. Mullany, Ph.D., of Baylor College of Medicine in Houston.
WASHINGTON--People with obesity who are hospitalized with COVID-19 have a significantly higher rate of ICU admissions and longer duration of ICU stay compared to people with a normal body mass index (BMI), according to a study presented virtually at ENDO 2021, the Endocrine Society's annual meeting.
WASHINGTON--Children with poorly controlled type 1 diabetes have a 10 times higher risk of COVID-19-related complications and death compared to those with well-controlled diabetes, according to a study presented virtually at ENDO 2021, the Endocrine Society's annual meeting.
WASHINGTON--Blood glucose levels improved among children and teens with type 1 diabetes during the first 12 weeks of COVID-19 lockdown in the United Kingdom, according to a study presented virtually at ENDO 2021, the Endocrine Society's annual meeting.
WASHINGTON--Women with obesity and polycystic ovarian syndrome (PCOS) are at increased risk of developing type 2 diabetes, according to a study presented virtually at ENDO 2021, the Endocrine Society's annual meeting. Normal-weight women with PCOS are not at increased risk, the researchers found.
Women with PCOS had a more than three-fold increased risk of developing type 2 diabetes during their lifetime, the study found. This risk was evident only in women who met the criteria for overweight or obesity, but not in lean women.
WASHINGTON--Only 3% of patients at high risk for primary aldosteronism (PA), a common disorder that causes high blood pressure and can lead to heart and kidney complications, are screened for the condition, according to a study that will be presented virtually at ENDO 2021, the Endocrine Society's annual meeting.
"The results of our study indicate that initiatives to encourage PA screening are crucial for preventing cardiovascular and kidney disease in many patients with hypertension," said lead researcher Seda Grigoryan, M.D., of Michigan State University in Lansing, Mich.
WASHINGTON--A lifestyle intervention targeting women with obesity and infertility is more effective in increasing the pregnancy rate compared with fertility treatments, according to a study presented virtually at ENDO 2021, the Endocrine Society's annual meeting.
WASHINGTON--Transgender youth have higher odds than cisgender youth of being diagnosed with medical conditions that can affect their overall metabolic and cardiovascular health, according to a study presented virtually at ENDO 2021, the Endocrine Society's annual meeting.
WASHINGTON--Black women with polycystic ovary syndrome (PCOS) have higher risk factors for heart disease, diabetes and stroke compared with white women, according to a study presented virtually at ENDO 2021, the Endocrine Society's annual meeting.
PCOS is a common disorder characterized by irregular menstrual periods, disruption of normal metabolism and excessive hair growth. PCOS affects up to 10% of all women of reproductive age. The disorder increases the risk for health conditions including infertility, obesity, heart disease, type 2 diabetes, depression and certain cancers.
WASHINGTON--Endogenous Cushing's syndrome, a rare hormonal disorder, is associated with a threefold increase in death, primarily due to cardiovascular disease and infection, according to a study whose results will be presented at ENDO 2021, the Endocrine Society's annual meeting.