Body
Philadelphia, April 20, 2021 - Intestinal epithelial tight junctions (TJs) act as a functional and structural barrier against harmful antigens that promote intestinal inflammation in inflammatory bowel disease (IBD) and other inflammatory conditions of the gut. A defective intestinal TJ barrier, sometimes known as "leaky gut," plays an important role in exacerbating and prolonging intestinal inflammation.
UNIVERSITY PARK, Pa. -- As vaccines that help protect against COVID-19 become available for more people across the United States, questions have been raised about whether institutions like schools and universities should require their students and staff to become vaccinated.
OKLAHOMA CITY -- With an overall survival rate of 9% for those diagnosed, pancreatic cancer remains exceedingly difficult to treat. However, the patient's primary tumor typically isn't what leads to death - it is the cancer's ability to evade detection and metastasize to other organs.
Varying severity of COVID-19 symptoms in patients is reflected by levels of a chemical biomarker in their body which scientists say could be used to better manage treatments and other interventions, including vaccinations.
In a new paper in International Journal of Infectious Diseases, medical experts in Italy and Australia examined levels of a chemical called serum amyloid A (SAA), a protein synthesised in the liver which can spike up to 1,000-fold within the first 24-48 hours of an infection.
DALLAS, April 19, 2021 — Gender-affirming hormone therapy (GAHT) was associated with blood pressure changes in both transgender men and women, according to new research published today in Hypertension, an American Heart Association journal. Given the higher burden of heart attack, stroke and other cardiovascular conditions among transgender men and women, blood pressure screening and monitoring are important, especially after beginning hormone therapies.
Anyone sexually active under age 30 should be offered testing for chlamydia and gonorrhea, according to a new guideline from the Canadian Task Force on Preventive Health Care published in CMAJ (Canadian Medical Association Journal).
What The Study Did: This population-based study of multiple databases from Canada found no association between epidural labor pain relief and risk of autism spectrum disorders in children.
Authors: Elizabeth Wall-Wieler, Ph.D., of the University of Manitoba in Winnipeg, Canada, is the corresponding author.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamapediatrics.2021.0376)
What The Study Did: This study examined the association of paternal drinking before pregnancy with the risk of birth defects in children among couples in China.
Authors: Xiaotian Li, M.D., Ph.D., of Obstetrics and Gynecology Hospital of Fudan University in Shanghai, China, is the corresponding author.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamapediatrics.2021.0291)
Scientists have for the first time captured the complex dynamics of particle movement in granular materials, helping to explain why mixed nuts often see the larger Brazil nuts gather at the top. The findings could have vital impact on industries struggling with the phenomenon, such as pharmaceuticals and mining.
Chronic lower-limb edema (CLE) -- the permanent accumulation of fluid in the leg -- often occurs in elderly people. The condition leads to various physical and mental problems, including difficulty in walking or moving, fatigue and anxiety. One cause of CLE is the lack of physical activity, which is associated with a decrease in muscle pump action. The latter refers to the leg muscle's acting as a blood pump: when contracted, the muscle squeezes veins together, forcing blood to flow.
The research is conducted by Kazan University's Open Lab Gene and Cell Technologies (Center for Precision and Regenerative Medicine, Institute of Fundamental Medicine and Biology) and Republic Clinical Hospital of Kazan. Lead Research Associate Yana Mukhamedshina serves as project head.
Boston - Transgender people have a higher burden of cardiovascular disease and hypertension than cisgender people. However, while doctors have prescribed gender-affirming hormone therapy to transgender men and women for more than 25 years, little is known about how this treatment may impact rates of hypertension in this patient population or how the effects of hormone therapy on blood pressure may change over time.
PHILADELPHIA - A new gene therapy for one of the most common forms of congenital blindness was safe and improved patients' vision, according to initial data from a clinical trial led by researchers at the Scheie Eye Institute in the Perelman School of Medicine at the University of Pennsylvania.
DALLAS - April 19, 2021 - Treating people with Type 2 diabetes with a new once-a-week injectable insulin therapy proved to be safe and as effective as daily insulin injections, according to the results of two international clinical trials published online today in Diabetes Care.
BOSTON - At the end of 2020, experts led by allergists at Massachusetts General Hospital (MGH) examined all information related to possible allergic reactions to COVID-19 vaccinations. Now the team has published updated insights based on their experience overseeing more than 65,000 employees who have become fully vaccinated since that time. The group's latest findings are published in the Journal of Allergy and Clinical Immunology: In Practice.