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PHILADELPHIA -- (April 22, 2021) -- A synthetic DNA vaccine candidate for Middle East respiratory syndrome coronavirus (MERS-CoV) developed at The Wistar Institute induced potent immune responses and afforded protective efficacy in non-human primate (NHP) models when given intradermally in abbreviated, low-dose immunization regimen. A similar vaccine candidate was previously shown to be safe and tolerable with a three-dose intramuscular injection regimen in a recently completed human phase 1 study and is currently in expanded studies of phase 1/2a trial.
AUSTIN, Texas -- Despite advances in medicine and technology, childbirth isn't likely to get much easier on women from a biological perspective.
In a worldwide study of 2,100 pregnant women, those who contracted COVID-19 during pregnancy were 20 times more likely to die than those who did not contract the virus.
UW Medicine and University of Oxford doctors led this first-of-its-kind study, published today in JAMA Pediatrics. The investigation involved more than 100 researchers and pregnant women from 43 maternity hospitals in 18 low-, middle- and high-income nations; 220 of the women received care in the United States, 40 at UW Medicine. The research was conducted between April and August of 2020.
PHILADELPHIA-- Art appreciation is considered essential to human experience. While taste in art varies depending on the individual, cognitive neuroscience can provide clues about how viewing art affects our neural systems, and evaluate how these systems inform our valuation of art.
Researchers at Carnegie Mellon University and McGill University have adapted an algorithm first developed to spot anomalies in data, like typos in patient information at hospitals or errant figures in accounting, to identify similarities across escort ads.
The algorithm scans and clusters similarities in text and could help law enforcement direct their investigations and better identify human traffickers and their victims, said Christos Faloutsos, the Fredkin Professor in Artificial Intelligence at CMU's School of Computer Science, who led the team.
BOSTON - Exclusively using (or "vaping") e-cigarettes can help people quit smoking, but many people using e-cigarettes to quit smoking continue to smoke cigarettes. New research led by investigators at Massachusetts General Hospital (MGH) reveals that respiratory symptoms--such as cough and wheeze--are more likely to develop when people use both e-cigarettes and tobacco cigarettes together compared with using either one alone.
BOSTON - Legislation currently under consideration in the U.S. Congress would increase regulatory oversight of certain diagnostic tests, and a new study by researchers at Massachusetts General Hospital (MGH) and colleagues from several other institutions demonstrates that its potential impact will depend on key details in the bill's final language.
DALLAS, April 22, 2021 -- People with abdominal obesity and excess fat around the body's mid-section and organs have an increased risk of heart disease even if their body mass index (BMI) measurement is within a healthy weight range, according to a new Scientific Statement from the American Heart Association published today in the Association's flagship journal, Circulation.
BOSTON -- Radiation therapy is used as a treatment for more than half of all cancer patients and can be highly effective at shrinking tumors and killing cancer cells. But radiation treatment can also damage healthy tissue, including tissue in the mouth and gastrointestinal tract. This tissue injury can lead to oral mucositis, esophagitis, and proctitis -- painful and sometimes debilitating tissue damage. It's estimated that these injuries occur in over 200,000 patients in the U.S. each year.
Bottom Line: When given a choice, most individuals with an average risk of colorectal cancer said they would prefer a stool-based screening test for colorectal cancer over colonoscopy, the method most often recommended by health care providers.
Journal in Which the Study was Published: Cancer Prevention Research, a journal of the American Association for Cancer Research
Author: Xuan Zhu, PhD, senior health services analyst at the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery
INDIANAPOLIS -- A team from Regenstrief Institute leveraged OpenMRS, a global open-source electronic medical record (EMR), to create an emergency EMR for Indianapolis first responders preparing for a possible influx of COVID-19 patients. This process was completed in a week to allow Indianapolis Emergency Medical Services (IEMS) to register patients, collect basic clinical information, and send these encounters to Indiana's health information exchange, a crucial element to help the response to the COVID-19 pandemic.
Scientists have shown that the biological molecule PD-L1 is a potential target for the treatment of metastasized oral malignant melanoma in dogs.
There are a number of cancers that affect dogs, but there are far fewer diagnosis and treatment options for these canine cancers. However, as dogs and humans are both mammals, it is likely that strategies and treatments for cancers in humans can be used for canine cancer, with minor modifications.
Notch proteins are key regulators of growth and differentiation of both normal and cancer cells. Researchers in Turku, Finland, have now demonstrated that the activities of distinct Notch family members are modified differently by phosphorylation. These results can be used in the development of new cancer treatments, especially for hormone-dependent breast cancer.
OAK BROOK, Ill. - An artificial intelligence-driven system that automatically combs through brain MRIs for abnormalities could speed care to those who need it most, according to a study published in Radiology: Artificial Intelligence.
MINNEAPOLIS - Intracerebral hemorrhage is a life-threatening type of stroke caused by bleeding within the brain tissue. Survivors are at high risk of having another bleeding stroke. Most of these strokes are caused by changes in the narrowest blood vessels in the brain, a condition known as cerebral small vessel disease. A new study has found that differences in the extent of one type of cerebral small vessel disease may contribute to differences in people's risk for a second bleeding stroke.