Body

BOUDRY, Switzerland--(December 10, 2008)--Celgene International Sarl (Nasdaq: CELG) today announced that its next IMiDs compound, pomalidomide, has shown promising activity with manageable safety and tolerability for the treatment of relapsed/refractory multiple myeloma (MM) and myelofibrosis. The data were presented at the 50th Annual American Society of Hematology meeting in San Francisco, CA.

BOUDRY, Switzerland--(December 10, 2008)--Celgene International Sarl (NASDAQ: CELG) announced that data from a landmark analysis of patients with relapsed/refractory multiple myeloma found that continuous treatment with REVLIMID (lenalidomide) in combination with dexamethasone after achieving best response resulted in significantly longer overall survival and increased time to disease progression compared to those who discontinued treatment after ten months or less. The results of this analysis were presented today at the 50th Annual Meeting of the American Society of Hematology (ASH).

Crosswicks, NJ – (December 10, 2008) – The Myelodysplastic Syndromes (MDS) Foundation announced today that a subanalysis of the AZA-001 phase III international clinical trial shows that treatment with VIDAZA (azacitidine) can extend overall survival and reduce the risk of death in elderly higher-risk MDS patients.

Crosswicks, NJ – (December 10, 2008) – The Myelodysplastic Syndromes (MDS) Foundation announced today that a new analysis of the AZA-001 phase III clinical trial demonstrates that continued treatment with VIDAZA (azacitidine) can improve response rates for higher-risk MDS patients.

Crosswicks, NJ – (December10, 2008) – The Myelodysplastic Syndromes (MDS) Foundation announced today that data presented at this year's American Society of Hematology (ASH) Meeting in San Francisco demonstrate that patients with acute myeloid leukemia (AML) who were treated with VIDAZA (azacitidine) had significantly increased overall survival compared to those treated with conventional care regimens (CCR).

AUGUSTA, Ga. - Children with diabetes are at an increased risk for developing eating disorders and researchers want to know if it's their disease or treatment that's to blame.

(Boston, Mass.) – Deaths due to dementia and Alzheimer's disease are underreported on death certificates, according to a study conducted by Hebrew SeniorLife's Institute for Aging Research (IFAR), raising concerns about the accuracy of mortality statistics based on these documents.

Athens, Ga. - Pharmaceutical companies and universities are racing to develop drugs that use the gene silencing mechanism known as RNA interference to treat a host of diseases. Now, a new study opens up an entirely new possibility for this powerful tool: Researchers at the University of Georgia have demonstrated for the first time that RNA interference can be used as a tool in the development of vaccines.

St. Louis, December 10, 2008 — Researchers may have identified one of the body's earliest responses to a group of parasites that causes illness in developing nations.

In a paper published online in Public Library of Science Pathogens, scientists report that they tracked immune cells as they patrolled the second-shallowest layer of the skin in an animal model. Injections of a genetically modified form of the parasite Leishmania major caused the immune cells to turn from their patrols and move to intercept the parasites.

Cold Spring Harbor, N.Y. – Much like cancer cells, plant cells grown for a long time outside of their normal milieu, in culture dishes, have highly unstable genomes. Changes in gene activity, or how genes are "expressed," help cells cope with challenging culture conditions but inadvertently also leave genes prone to mis-regulation by transposons -- bits of DNA that can jump around in the genome, inserting themselves into random genetic locations, often disrupting normal gene function and regulation.

A University of British Columbia geneticist has discovered a gene mutation that can cause the most common eye cancer - uveal melanoma.

Catherine Van Raamsdonk, an assistant professor of medical genetics in the UBC Faculty of Medicine and a team of researchers, have discovered a genetic mutation in a gene called GNAQ that could be responsible for 45 per cent of the cases of uveal melanoma.

The findings, published today in Nature, will allow researchers to develop therapeutic interventions against some melanomas.

By blocking PD-1 (programmed death-1), an immune receptor molecule known to inhibit the immune response to chronic viral infections, scientists have safely and significantly reduced the plasma viral load and also prolonged survival of rhesus macaque monkeys severely infected with simian immunodeficiency virus (SIV), the nonhuman primate version of human immunodeficiency virus (HIV). The therapeutic strategy worked by boosting the function of anti-viral killer cells (CD8 T cells) and improving antibody response to the virus.

STANFORD, Calif. — Like it or not, your living room probably says a lot about you. Given a few uninterrupted moments to poke around, a stranger could probably get a pretty good idea of your likes and dislikes, and maybe even your future plans. Scientists at the Stanford University School of Medicine employing a similar "peeping Tom" tactic to learn more about how stem cells develop have taken a significant step forward by devising a way to recreate the cells' lair — a microenvironment called a niche — in an adult animal.

HOW quickly HIV turns into AIDS might depend on an individual's DNA. Some variations in the DNA in mitochondria, the parts of cells that generate energy, seem to make AIDS develop twice as fast as others.

Stephen O'Brien from the National Cancer Institute in Frederick, Maryland, and colleagues examined data from five long-term studies tracking a total of 1833 people with HIV during the 1980s and early 1990s. This was before antiretroviral therapy (HAART) was commonly used, so the team could follow the disease's development without intervention.

California's low-income teenagers have a lot in common: Sugary soda. Fast-food restaurants. Too much television. Not enough exercise. The result: Low-income teenagers are almost three times more likely to be obese than teens from more affluent households, according to new research from the UCLA Center for Health Policy Research.