Researchers at UCLA's Jonsson Comprehensive Cancer Center, on a quest to find lung cancer stem cells, have developed a unique model to allow further investigation into the cells that many believe may be at the root of all lung cancers.
If researchers could find a way to isolate and grow lung cancer stem cells, they could study their biologic mechanisms and perhaps identify targets for new therapies, said Raj Batra, an associate professor of medicine and a Jonsson Cancer Center scientist.
A new study by The George Institute for International Health has found Tai Chi to have positive health benefits for musculoskeletal pain. The results of the first comprehensive analysis of Tai Chi suggest that it produces positive effects for improving pain and disability among arthritis sufferers.
The researchers are now embarking on a new trial to establish if similar benefits can be seen among people with chronic low back pain.
PHOENIX, Ariz. – June 16, 2009 – Translational Genomics Research Institute (TGen) scientists have identified five genetic biomarkers that could help lead to improved treatments, with fewer side-effects, for patients with diabetes.
TGen Senior Investigator Dr. Johanna DiStefano presented the findings in New Orleans on June 6, 2009, at the 69th Scientific Sessions of the American Diabetes Association.
A team of researchers from the University of Cadiz has confirmed that zinc, copper and lead are present at high levels in the water and sediments of the Huelva estuary, and have studied how some of these heavy metals are transferred to fish. The study shows that zinc, cadmium and copper accumulate in the body tissues of sole and gilthead bream.
Researchers at The Medical College of Wisconsin in Milwaukee published the first initial paper describing the Milwaukee prevalence of the largest outbreak of novel swine origin influenza virus (S-OIV) in America in the June 11, 2009, online issue of Viruses. This corresponded to the announcement by World Health Organization of the first influenza pandemic in 41 years.
ROCHESTER, Minn. -- Mayo Clinic cardiology researchers have found a peptide that helps preserve and improve kidney function during heart failure, without affecting blood pressure. Earlier variations of this peptide caused blood pressure to drop limiting the potential benefits to the kidneys. The findings appear in the current Proceedings of the National Academy of Sciences.
CHAPEL HILL, N.C. – In 2004, researchers at the University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center announced a crucial discovery in the understanding of cellular aging. They found that as cells and tissues age, the expression of a key protein, called p16INK4a, dramatically increases in most mammalian organs. Because p16INK4a is a tumor suppressor protein, cancer researchers are interested in its role in cellular aging and cancer prevention.
ST. LOUIS – In a multi-center trial led by a Saint Louis University researcher, investigators found that a new combination therapy of daily consensus interferon and ribavirin helps some hepatitis C patients who have not responded to previous treatment. The findings, published in the June issue of Hepatology, offer a new option for hepatitis C patients, and may be effective even for those patients with factors that make their condition difficult to treat.
Why aren't birds larger? Fifteen-kilogram swans hold the current upper size record for flying birds, although the extinct Argentavis of the Miocene Epoch in Argentina is estimated to have weighed 70 kilograms, the size of an average human. In a forthcoming article in PLoS Biology, Sievert Rohwer, and his colleagues at the Burke Museum at the University of Washington, provide evidence that maximum body size in birds is constrained by the amount of time it takes to replace the flight feathers during molt.
Water is a crucial ingredient for life, but its level inside cells must be carefully regulated to maintain proper cell shape and size. In this week's issue of the open access journal PLoS Biology, scientists from the University of Gothenburg describe the highest resolution three-dimensional structure yet of a membrane protein, in this case of a protein channel known as an aquaporin that regulates water flow into and out of yeast cells. Virtually all living organisms use aquaporins to regulate water flow between the cell and its surroundings.
Our understanding of the importance of microRNAs in regulating gene expression is expanding, and with it our requirement for robust methods to measure their expression levels. Now a new method published in BioMed Central's open access journal Genome Biology helps researchers to better understand the delicate interplay between differences in microRNA expression levels and their target genes.
Neurological diseases including Parkinson's, Tourette's, attention deficit hyperactivity disorder (ADHD), Alzheimer's, and schizophrenia are all associated with alterations in dopamine-driven function involving the dopamine transporter (DAT). Research published today in the open access journal BMC Neuroscience suggests that a number of estrogens acting through their receptors affect the DAT, which may explain trends in timing of women's susceptibility to these diseases.
On the 25th anniversary of the project that brought the large blue butterfly back from extinction in the United Kingdom, ecologists are for the first time publishing the decades of research that helped them rescue this spectacular butterfly.
June 15, 2009 — (BRONX, NY) — In a study published in The Journal of Infectious Diseases, researchers from Albert Einstein College of Medicine of Yeshiva University have identified cells in blood that predict which HIV-positive individuals are most likely to develop deadly fungal meningitis, a major cause of HIV-related death. This form of meningitis affects more than 900,000 HIV-infected people globally—most of them in sub-Saharan Africa and other areas of the world where antiretroviral therapy for HIV is not available.
CAMBRIDGE, Mass. (June 11, 2009) – A low cellular level of a tiny fragment of RNA appears to increase the spread of breast cancer in mouse models of the disease, according to researchers at Whitehead Institute for Biomedical Research.
Measuring levels of this so-called microRNA, which is also associated with metastatic breast cancer in humans, may more accurately predict the likelihood of metastasis (which accounts for 90% of cancer-related deaths) and ultimately help determine patient prognoses.