WEST LAFAYETTE, Ind. - A Purdue University scientist has discovered a key process in cell growth that can lead to the formation of tumors.
Xiaoqi Liu, an assistant professor of biochemistry, found that an overabundance of the polo-like kinase 1, or Plk1, molecule during cell growth, as well as a shortage of the p53 molecule, will lead to tumor formation. Studies in Liu's laboratory showed that the Plk1 molecule indirectly attacks p53 in a process called ubiquitination.
INDIANAPOLIS – Structural cardiovascular abnormalities present at birth are the leading cause of heart failure in children. Nearly half a million children in the United States have structural heart problems ranging in severity from relatively simple issues, such as small holes between chambers of the heart, to very severe malformations, including complete absence of one or more chambers or valves.
A new Northwestern University-led study of human colon, pancreatic and lung cells is the first to report that cancer cells and their non-cancerous cell neighbors, although quite different under the microscope, share very similar structural abnormalities on the nanoscale level.
The findings, obtained using an optical technique that can detect features as small as 20 nanometers, validate the "field effect," a biological phenomenon in which cells located some distance from a malignant or premalignant tumor undergo molecular and other kinds of abnormal changes.
The active form of vitamin D3 seems to have anticancer effects. To try and understand the mechanisms underlying these effects, researchers previously set out to identify genes whose expression in a human colon cancer cell line was altered by the active form of vitamin D3. One gene identified in this previous study was CST5, which is responsible for making the protein cystatin D.
Infants who weigh less than five and a half pounds at birth often enter the world with a host of medical complications, including respiratory problems. New research shows that these respiratory problems may persist well beyond their infancy and childhood and into adulthood.
Blacksburg, Va. – A research paper co-written by a Virginia Tech faculty member explains a 60-year mystery behind a rare bat's nose that is unusually large for its species. The findings soon will be published in the scientific trade journal, Physical Review Letters.
BOSTON—Stressing out can cause people to gain weight, according to a study appearing in the July 15 issue of the American Journal of Epidemiology. This new study is believed to be one of the first of its kind to look at the relationship between weight gain and multiple types of stress—job-related demands, difficulty paying bills, strained family relationships, depression or anxiety disorder—in the U.S. population.
FAIRFAX, Va.—"Society of Interventional Radiology 2009 Standards Division Guidelines" is the subject of a special supplement to the July issue of the Journal of Vascular and Interventional Radiology.
Plant roots provide the crops we eat with water, nutrients and anchorage. Understanding how roots grow and how hormones control that growth is crucial to improving crop yields, which will be necessary to address food security and produce better biofuels.
Now an international group of scientists, led by the Centre for Plant Integrative Biology at The University of Nottingham, has shed light on how a plant hormone is crucial in controlling the growth of plant roots.
DURHAM, N.C. – The virus that causes AIDS is classified as a lentivirus, a word derived from the Latin prefix, "lenti-," meaning "slow." But new research from the NIAID-funded Center for HIV/AIDS Vaccine Immunology suggests that HIV-1 is anything but – moving at breathtaking speed in destroying and dysregulating the body's gut-based B-cell antibody-producing system.
San Diego, July 7, 2009 –The recent global swine flu outbreak has underscored the critical need for good surveillance and rapid access to epidemiological data. The US military, starting with early monitoring efforts in the 1970s, has developed a broad-based influenza monitoring system.
Research conducted by a team of Swedish and Polish researchers and published in PNAS (Proceedings of the National Academy of Sciences) seems to confirm the identity of his putative remains as Nicolaus Copernicus. The researchers analyzed strands of hair found in a book once owned by Copernicus and now kept at the Museum Gustavianum, Uppsala University.
An international team of researchers has studied the coralline algae fossils that lived on the last coral reefs of the Mediterranean Sea between 7.24 and 5.3 million years ago. Mediterranean algae and coral reefs began to resemble present day reefs following the isolation of the Mediterranean from the Indian Ocean and global cooling 15 and 20 million years ago respectively.
Preventive operations are being used more and more often to treat abdominal aortic aneurysms. Even though the operation is now being offered to ever older and sicker patients, the long-term survival of those who have had the operation has improved over the last two decades. This is shown in a major Swedish study in which researchers from Uppsala University examined 12,000 patients. The findings are published in Circulation: Journal of the American Heart Association.
Male seahorses have a clear agenda when it comes to selecting a mating partner: to increase their reproductive success. By being choosy and preferring large females, they are likely to have more and bigger eggs, as well as bigger offspring, according to Beat Mattle and Tony Wilson from the Zoological Museum at the University of Zurich in Switzerland. Their findings1 have just been published online in Springer's journal Behavioral Ecology and Sociobiology.