Some babies who are exposed to malaria before birth develop a tolerant phenotype that increases their susceptibility to malaria and anemia in childhood, says a new study in the open access journal PLoS Medicine.
Body
Although macrophages are known as essential players in wound healing, their contribution to recovery from spinal cord injury is a subject of debate. Using a mouse model of spinal injury, Michal Schwartz and colleagues from the Weizmann institute of Science, Rehovot, Israel tested the effect of macrophages on the recovery process after injury and demonstrate an important anti-inflammatory role for a subset of infiltrating monocyte-derived macrophages that is dependent upon their expression of the anti-inflammatory molecule interleukin-10.
A new study by Howard Hughes Medical Institute researchers shows that most early-stage ovarian tumors exist for years at a size that is a thousand times smaller than existing tests can detect reliably.
But the researchers say their findings also point to new opportunities for detecting ovarian cancer—a roughly four-year window during which most tumors are big enough to be seen with a microscope, but have not yet spread.
The mechanism used by 'Natural Killer' immune cells in the human body to distinguish between diseased cells, which they are meant to destroy, and normal cells, which they are meant to leave alone, is revealed in new detail in research published today (Tuesday 28 July) in PLoS Biology.
Understanding how this aspect of the body's natural defences works could help medical researchers develop new ways of boosting these defences to treat disease.
A team of researchers from Case Western Reserve University School of Medicine have solved the mystery of why some children are more susceptible to malaria infection and anemia. These novel findings suggest that some children who are exposed to Plasmodium falciparum (P. falciparum) malaria before birth become tolerant to the malaria parasites, or their soluble products. This tolerance, which persists into childhood, reduces the ability of the immune system to attack and destroy parasites and increases the susceptibility of these children to develop a malaria infection.
Daylight photoreceptors and UV sensitivity in the retinas of nocturnal bats
A model of influenza transmission and treatment suggests that, if the current swine flu pandemic behaves like the 1918 flu, antiviral treatment should be reserved for the young. Researchers writing in the open access journal BMC Infectious Diseases found that, in this situation, providing the elderly with antiviral drugs would not significantly reduce mortality, and may lead to an increase in resistance.
Since trade liberalization between Central and North America, imports and availability of processed, high-fat and high-sugar foods have increased dramatically. Researchers writing in BioMed Central's open access journal Globalization and Health link this influx of American junk food to a 'nutrition transition' in Central American countries, with a growing burden diet-related chronic disease.
New research suggests that current regulations have failed to remove misleading information from cigarette packaging, revealing that a substantial majority of consumers believe cigarettes are less hazardous when the packs display words such as "silver" or "smooth," lower numbers incorporated into the brand name, lighter colours or pictures of filters.
WASHINGTON, D.C. July 27, 2009 -- Canadian scientists at the University of Alberta's Cross Cancer Institute are developing a new technology that integrates two existing medical devices -- medical linear accelerators, or "linacs," which produce powerful X-rays for treating cancer, and magnetic resonance imagers (MRIs), which are widely used to image tumors in the human body.
A comprehensive analysis of nearly 1,600 tumor samples has found that CT-X genes are expressed in nearly half the breast cancers that lack the estrogen receptor (ER). CT-X gene products are the targets of therapeutic cancer vaccines already in phase III clinical trials for lung cancer and melanoma. The study—to be published in the Early Edition of the Proceedings of the National Academy of Sciences this week—was led by the international Ludwig Institute for Cancer Research (LICR).
STANFORD, Calif. — A drug used to remove iron from the body could help doctors fight one of diabetes' cruelest complications: poor wound healing, which can lead to amputation of patients' toes, feet and even legs.
Striking differences in the risk factors for developing heart failure (HF) and patient prognosis exist between men and women. Men and women may also respond differently to treatment, raising concerns about whether current practices provide the best care and reinforcing the urgency for sex-specific clinical trials for HF, according to a review article published in the August 4, 2009, issue of the Journal of the American College of Cardiology.
RIVERSIDE, Calif. – Evidence for life on Earth stretches back billions of years, with simple single-celled organisms like bacteria dominating the record. When multi-celled animal life appeared on the planet after 3 billion years of single cell organisms, animals diversified rapidly.
Conventional wisdom has it that animal evolution began in the ocean, with animal life adapting much later in Earth history to terrestrial environments.
Two University of British Columbia researchers are part of an international team recommending standards for the DNA barcoding of land plants, a step they hope will lead to a universal system for identifying over 400,000 species, and ultimately boost conservation efforts.