July 30, 2009—A study published online ahead of press in the Gerontology Society of America's Journal of Gerontology: Medical Sciences reports that the condition of frailty in older adults is associated with a critical mass of abnormal physiological systems, over and above the status of each individual system, and that the relationship is nonlinear. This research is the first evidence that frailty is related to the number of abnormal physiological systems, rather than a specific system abnormality, a chronic disease, or chronological age.
Body
Everyone knows that vitamins "from A to zinc" are important for good health. Now, a new research study in the August 2009 print issue of the Journal of Leukocyte Biology (http://www.jleukbio.org) suggests that zinc may be pointing the way to new therapeutic targets for fighting infections. Specifically, scientists from Florida found that zinc not only supports healthy immune function, but increases activation of the cells (T cells) responsible for destroying viruses and bacteria.
Two researchers from the Polytechnic University of Catalonia (UPC) and the University of Aberdeen in the United Kingdom have shown for the first time that the law of brevity in human language, according to which the most frequently-used words tend to be the shortest, also extends to other animal species. The scientists have shown that dolphins are more likely to make simpler movements at the water surface.
A UK hospital that combined its bereavement and donation services saw a forty-fold increase in tissue donations, such as corneas, in just five years, according to research in the August issue of Anaesthesia.
"We decided to address the problem of low organ and tissue donation rates by amalgamating the two services and introducing a trigger to automatically refer all potential organ donors to the regional transplant donor co-ordinators" explains Bereavement and Donor Co-ordinator Fiona Murphy from the Royal Bolton Hospital, UK.
NEWPORT, Ore. – Scientists are comparing annual growth rings of the Pacific Northwest's largest bivalve and its most iconic tree for clues to how living organisms may have responded to changes in climate.
Analyzed by themselves, the rings from a single tree or mollusk may sometimes reflect conditions that are either favorable or unfavorable for growth. When scientists look at numerous individuals of the same species, however, the consistency of the ring patterns allows them to build a model and compare that to known climatic measurements.
This study consisted of 10 patients (three male and seven female) with hepatic angiomyolipoma, with a mean age of 55.1 years (age range, 19-78 years). Of these patients, dynamic contrast CT showed hepatic angiomyolipoma as a hypervascular mass with intratumoral fatty density, absence of a capsule, and prominent central vessels in six sporadic cases, and multiple, small hepatic angiomyolipomas, with or without a fat component in four cases with tuberous sclerosis complex (TSC). Lymphangioleiomyomatosis (LAM) and multiple hepatic angiomyolipomas were found in one patient with TSC.
UCSF researchers have identified a new potential drug target for the herpes virus that causes Kaposi's sarcoma, re-opening the possibility of using the class of drugs called protease inhibitors against the full herpes family of viruses, which for 20 years has been deemed too difficult to attain.
Older adults who have less strength, poor physical function and low muscle density are at higher risk of being hospitalized compared to adults with more strength and better function. That's the finding of a new study in the Journal of the American Geriatric Society.
The study also found that muscle density, a measure of how much fat compared to lean tissue there is in the muscle, is a more accurate gauge of a person's risk of hospitalization than muscle mass or size. The relative risk for hospitizations was 50% higher for those with poor walking or less dense muscle mass
Osteoarthritis (OA), the most common joint disorder throughout the world and a leading cause of disability, is characterized by pain, impaired joint mobility, reduction of muscular strength and loss of joint function. Unlike most other common diseases, little is known about its origins, and factors predicting a severe disease course have not been identified. A new study, the first to establish a laboratory marker for the risk of severe OA, found that vascular cell adhesion molecule 1 (VCAM-1), was a strong predictor of hip and knee joint replacement due to severe OA.
DALLAS – July 30, 2009 – The typical dose of a medication considered pivotal in treating tuberculosis effectively is much too low to account for modern-day physiques, UT Southwestern Medical Center researchers said.
The finding, reported online and in the August edition of Antimicrobial Agents and Chemotherapy, is particularly important for those living in societies plagued by obesity, said Dr. Tawanda Gumbo, associate professor of internal medicine at UT Southwestern and the study's lead author.
Ultrasound can be used to determine a patient's heart risk after a transient ischemic attack (TIA). An evaluation of transcranial (TCD) and extracranial (ECD) Doppler ultrasonography, published in the open access journal BMC Medical Imaging, has shown that both future stroke and future cardiovascular ischemic events can be predicted by abnormal findings.
ATLANTA (July 29, 2009) – A systematic literature review of mothers' experiences with bottle-feeding found that while mothers recognize the benefits of breastfeeding, those who bottle-feed with infant formula do not receive adequate information and support from their healthcare providers and thus, ultimately put their baby's health at risk. "While it is important to promote breastfeeding," the authors conclude, "it is also necessary to ensure that the needs of bottle-feeding mothers are not overlooked."
Malaria parasites in western Cambodia have become resistant to artemisinin-based therapies, the first-line treatment for malaria, according to a study published in the New England Journal of Medicine today. Resistance to the drugs makes them less effective and could eventually render them obsolete, putting millions of lives at risk.
HOUSTON - With a novel therapeutic delivery system, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center has successfully targeted a protein that is over-expressed in ovarian cancer cells. Using the EphA2 protein as a molecular homing mechanism, chemotherapy was delivered in a highly selective manner in preclinical models of ovarian cancer, the researchers report in the July 29 issue of the Journal of the National Cancer Institute.
The cowpea or black-eyed pea, as it is more commonly known, is a New Year's tradition for good luck. But disease and aphids, which can wreck a crop within a few a days, are especially bad luck for the cowpea, according to scientists. Several new lines of cowpeas with genes that are aphid-resistant and less susceptible to disease are currently being tested.