Medical Research Council (MRC) scientists have made an important advance in understanding the biological processes involved when cells are prompted to die. The work may help scientists to eventually develop new treatments for the many common diseases and conditions which occur when cell death goes wrong.
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The cancer stem cells that drive tumor growth and resist chemotherapies and radiation treatments that kill other cancer cells aren't invincible after all. Researchers reporting online on August 13th in the journal Cell, a Cell Press publication, have discovered the first compound that targets those cancer stem cells directly.
"It wasn't clear it would be possible to find compounds that selectively kill cancer stem cells," said Piyush Gupta of the Massachusetts Institute of Technology (MIT) and the Broad Institute. "We've shown it can be done."
HOUSTON - A protein specialist that opens the genomic door for DNA repair and gene expression also turns out to be a multi-tasking workhorse that protects the tips of chromosomes and dabbles in a protein-destruction complex, a team lead by researchers at The University of Texas M. D. Anderson Cancer Center reports in the Aug. 13 edition of Molecular Cell.
p>CAMBRIDGE, Mass. (August 13, 2009) – A novel technique allows researchers to efficiently and precisely modify or introduce genes into the genomes of human embryonic stem cells (ESCs) and induced pluripotent stem (iPS) cells, according to Whitehead scientists. The method uses proteins called zinc finger nucleases and is described in the August 13 issue of Nature Biotechnology.
For years, scientists have easily swapped genes in and out of mouse ESC or iPS cell genomes, but have had a notoriously difficult time disrupting or inserting genes into their human equivalents.
Although open-heart surgery is a frequent treatment for heart disease, it remains extremely dangerous. Now groundbreaking research from Dr. Britta Hardy of Tel Aviv University's Sackler School of Medicine has shown the potential for an injected protein to regrow blood vessels in the human heart ― eliminating the need for risky surgery altogether.
Sandbar, dusky and tiger sharks are among dozens of shark species living in the coastal waters off the U.S. East Coast. Little is known about many of the species, but a survey begun nearly 25 years ago is helping scientists and fishery resource managers to monitor shark populations and their role in marine ecosystems.
SHAWNEE, Kan, 08/13/2009 – Bayer Animal Health announced today at the 22nd World Association for the Advancement of Veterinary Parasitology (WAAVP), Calgary, Canada the latest results of a large-scale, international, independent Flea Susceptibility Monitoring (FSM) program, demonstrating that imidacloprid remains highly effective for the control of fleas in companion animals.
Water striders, the familiar semi-aquatic bugs gliding across the lake at the cottage, have a novel body form that allows them to walk on water. This was not always the case. Achieving the gliding ability required the evolution of a unique arrangement of the legs, with the mid-legs greatly elongated. Scientists at the University of Toronto's Department of Ecology and Evolutionary Biology have discovered the gene behind this evolutionary change.
Grand Rapids, Mich. (Aug. 13, 2009) – The number of cancer deaths has declined steadily in the last three decades. Although younger people have experienced the steepest declines, all age groups have shown some improvement, according to a recent report in Cancer Research, a journal of the American Association for Cancer Research.
Porcine circovirus associated diseases cost pig producers around the world hundreds of millions of dollars each year.
That's why Kansas State University virologists Dick Hesse and Bob Rowland have been working to create new vaccines to tackle such complex diseases.
"Circovirus and its associated diseases continue to emerge around the world," Hesse said. "Both porcine reproductive and respiratory syndrome and circovirus are a worldwide problem and they continue to evolve."
DURHAM, N.C. – A new look at a large database of prostate cancer patients shows that obesity plays no favorites when it comes to increasing the risk of recurrence after surgery: Being way overweight is equally bad for blacks and whites, say researchers at Duke University Medical Center.
Walking outdoors in the fall, the splendidly colorful leaves adorning the trees are a delight to the eye. In Europe these autumn leaves are mostly yellow, while the United States and East Asia boast lustrous red foliage. But why is it that there are such differences in autumnal hues around the world? A new theory provided by Prof. Simcha Lev-Yadun of the Department of Science Education- Biology at the University of Haifa-Oranim and Prof.
Sewage plants remove organic matter from wastewater. If the accumulating sludge decays, biogas is generated as a by-product. However, only 1156 of the 10,200 sewage plants in Germany have a digestion tank. Smaller operations, especially, baulk at the costs of a new digestion tank. Instead, they enrich the sludge with oxygen in the existing activation basin, and stabilize it. "Activation basins require a lot of electricity. At the same time, enormous energy potential is lost, since no biogas is produced," says Dr.
LIVERPOOL, UK – 13 August 2009: Research at the University of Liverpool has found how mirror-image molecules gain control over each other and dictate the physical state of superstructures.
The team, in collaboration with University Hospital Aintree, the University of Warwick and researchers in Sweden, found that people classified as obese and those with pre-diabetes have raised levels of a protein called SPARC, that can cause tissue scarring. The research revealed that an increase in insulin, a hormone that controls blood sugar levels, and leptin, a hormone that regulates appetite, can trigger an increase in SPARC, which can prevent the proper storage of fat in fat tissue cells.