Body

Sept. 22, 2009 -- Sometimes to see something properly, you have to stand farther back. This is true of Chuck Close portraits where a patchwork of many small faces changes into one giant face as you back away.

It may also be true of the frogs of Central America, where the pattern of extinctions emerges clearly only at a certain spatial scale.

Everyone knows that frogs are in trouble and that some species have disappeared, but a recent analysis of Central American frog surveys shows the situation is worse than had been thought.

SAN FRANCISCO, CA – SEPTEMBER 21, 2009 – Two subset analyses from the landmark HORIZONS-AMI trial show that the anticoagulant bivalirudin lowers major bleeding and cardiac death versus the combination of heparin and a GP IIb/IIIa inhibitor in patients with ST-segment myocardial infarction (STEMI) who have disease of the left anterior descending artery (LAD), while in STEMI patients at highest risk for death, bivalirudin also confers the greatest mortality benefit.

Walter and Eliza Hall Institute researchers are part of an international team that has discovered a genetic variation that could identify those people infected with hepatitis C who are most likely to benefit from current treatments.

Dr Melanie Bahlo and Dr Max Moldovan from the institute's Bioinformatics division worked with researchers from the University of Sydney and elsewhere to analyse the genomes of more than 800 people, including more than 300 Australians, who were receiving treatment for chronic hepatitis C infection.

ANN ARBOR, Mich. — Immune therapies have been explored as a way to treat cancer after it develops. But a new study from the University of Michigan Comprehensive Cancer Center suggests that genetic risk of prostate cancer can be reduced by rescuing critical immune system cells.

The study was done in mice and would need further validation and extensive testing in the lab before being available for humans. But the results are promising for people with a strong family history of cancer or known cancer genes.

In the largest study of its kind, the international team of pathologists studied an initial 4,000 prostate cancer patients over a period of 15 years to further understanding into the natural progression of the disease and how it should be managed. The research, published in the British Journal of Cancer, could be used to develop a blood test to distinguish between aggressive and non-aggressive forms of prostate cancer.

Berlin, Germany: A group of scientists from Hamburg may have taken a big step towards more effective cancer drug development, Europe's largest cancer congress, ECCO 15 – ESMO 34 [1], heard today (Wednesday 23 September). Dr Ilona Schonn, Director of Cell Culture Research at Indivumed GmbH, told the conference that they had developed a preclinical drug test platform that would enable researchers to analyse tumour tissue for individual patient drug responses on the molecular level.

Berlin, Germany: One of the first of a series of trials to investigate the use of sorafenib – a targeted anti-cancer drug – for the treatment of advanced breast cancer has found that if it is combined with the chemotherapy drug, capecitabine, it makes a significant difference to the time women live without their disease worsening.

Berlin, Germany: Researchers have made significant advances in the treatment of metastatic malignant melanoma – one of the most difficult cancers to treat successfully once it has started to spread – according to a study to be presented at Europe's largest cancer congress, ECCO 15 – ESMO 34 [1], in Berlin on Thursday.

Berlin, Germany: Researchers have shown for the first time that patterns of ultrasound signals can be used to identify whether or not cancer has started to spread in melanoma patients, and to what extent. The discovery enables doctors to decide on how much surgery, if any, is required and to predict the patient's probable survival.

Active tuberculosis can be rapidly identified in patients with negative sputum tests by a new method, according to European researchers. Active tuberculosis (TB) is the seventh-leading cause of death worldwide, and while the diagnosis of active TB can be rapidly established when the bacteria can be identified on sputum microscopy, in about half of all cases, the TB bacterium cannot be detected, making another diagnostic option critical in efforts to control the spread of TB.

Researchers at the National Institute of Standards and Technology (NIST), in collaboration with private industry and other government agencies, have produced a new reference material for beryllium. Beryllium, an exotic metal used as a hardener in high-performance alloys and ceramics, can cause berylliosis—a chronic, incurable and sometimes fatal illness. The new reference material is expected to dramatically improve methods used to monitor workers' exposure and aid in contamination control as well as toxicological research.

Inventing a useful new tool for creating chemical reactions between single molecules, scientists at the National Institute of Standards and Technology (NIST) have employed microfluidics—the manipulation of fluids at the microscopic scale—to make microdroplets that contain single molecules of interest.

A research team at the National Institute of Standards and Technology (NIST) studying sugar-coated nanoparticles for use as a possible cancer therapy has uncovered a delicate balancing act that makes the particles more effective than conventional thinking says they should be. Just like individuals in a crowd respecting other people's personal space, the particles work because they get close together, but not too close.

The National Institute of Standards and Technology (NIST) has issued a new ruler, and even for an organization that routinely deals in superlatives, it sets some records. Designed to be the most accurate commercially available "meter stick" for the nano world, the new measuring tool—a calibration standard for X-ray diffraction—boasts uncertainties below a femtometer. That's 0.000 000 000 000 001 meter, or roughly the size of a neutron.