Body

A genetic study has found that small domestic dogs probably originated in the Middle East more than 12,000 years ago. Researchers writing in the open access journal BMC Biology traced the evolutionary history of the IGF1 gene, finding that the version of the gene that is a major determinant of small size probably originated as a result of the domestication of the Middle Eastern gray wolf.

Women who become pregnant with a single foetus after in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) have an increased risk of a stillbirth, according to new research out today (Wednesday).

The study of over 20,000 singleton pregnancies, published in Europe's leading reproductive medicine journal Human Reproduction [1], found a four-fold increased risk of stillbirths for women who had IVF/ICSI compared with women who conceived spontaneously or after fertility treatment that did not involve IVF or ICSI.

A structured physical activity programme at school can improve children's fitness and decrease body fat, a study published on bmj.com today shows.

A comparison of two strategies for treating severe sepsis or septic shock finds that using lactate levels measured in blood samples showed a similar short-term survival rate compared to a treatment regimen using central venous oxygen saturation measured using a specialized catheter, according to a study in the February 24 issue of JAMA.

Patients hospitalized with mild to moderate community-acquired pneumonia (CAP) should not be routinely prescribed prednisolone, a corticosteroid, as it is associated with a recurrence of symptoms after its withdrawal, according to the first randomized double-blind clinical trial to address the subject.

GAINESVILLE, Fla. — The origins of flowering plants from peas to oak trees are now in clearer focus thanks to the efforts of University of Florida researchers.

A study appearing online this week in the Proceedings of the National Academy of Sciences unravels 100 million years of evolution through an extensive analysis of plant genomes. It targets one of the major moments in plant evolution, when the ancestors of most of the world's flowering plants split into two major groups.

The adverse affects of being overweight are not limited to physical function but also extend to neurological function, according to research in the latest issue of the Journals of Gerontology Series A: Biological and Medical Sciences (Volume 65A, Number 1).

The publication presents a collection of ten articles highlighting new findings related to obesity in older persons.

Depression raises stress hormone levels in adolescent boys and girls but may lead to obesity only in girls, according to researchers. Early treatment of depression could help reduce stress and control obesity -- a major health issue.

Coral Gables, FL (February 23, 2010)—For the first time, scientists have sequenced the entire genome of the pea aphid, a notorious horticultural and agricultural pest. The findings reveal the extent of the genetic collaboration of the aphid host with its bacterial symbiont, which may account for some of the extraordinary characteristics of this insect.

PHILADELPHIA — Researchers have found a new oncogenic signaling pathway by which the environmental toxin arsenic may lead to adverse health effects, including bladder cancer. These study results are published in Cancer Research, a journal of the American Association for Cancer Research.

JACKSONVILLE, Fla. — Researchers at the Mayo Clinic campus in Florida have found that PKC-iota (PKC), an oncogene important in colon and lung cancers, is over-produced in pancreatic cancer and is linked to poor patient survival. They also found that genetically inhibiting PKC in laboratory animals led to a significant decrease in pancreatic tumor growth and spread.

The discovery, reported in the March 1 issue of Cancer Research, is especially encouraging, they say, because an experimental agent that targets PKC is already being tested in patients at Mayo Clinic.

In a laboratory study published in the journal Cancer Research, Scott & White Healthcare anatomic pathologist Arundhati Rao, M.D. is a co-investigator looking at the ways in which estrogen can interfere with how chemotherapy does its job in destroying breast cancer cells. The most common type of breast cancer is "estrogen-receptor positive" breast cancer.

Velusamy Rangasamy and Ajay Rana, Ph.D., are also the lead authors on the study and are based at Loyola University Medical Center in Chicago where Dr. Rana is a professor of pharmacology.

CHICAGO- When women hear the word menopause, they often think about hot flashes, hormone shifts and mood swings. But what about heart disease? Studies show a woman's risk of heart disease intensifies drastically around the time of natural menopause, which for most women is around the age of 50. This news may come as a surprise, but experts explain that understanding risk factors is an important first step, and reassure women that there are ways to lower your risk.

Patients hospitalized with mild to moderate community-acquired pneumonia (CAP) should not be routinely prescribed prednisolone, a corticosteroid, as it is associated with a recurrence of symptoms after its withdrawal, according to the first randomized double-blind clinical trial to address the subject.