University of Washington (UW) researchers have identified a gene involved in susceptibility and resistance to tuberculosis. This same gene, they have found, has a role in the severity of leprosy, which is caused by a related pathogen. The researchers also have learned why this gene is important for susceptibility.
Body
In the long evolutionary road from bacteria to humans, a major milestone occurred some 1.5 billion years ago when microbes started building closets for all their stuff, storing DNA inside a nucleus, for example, or cramming all the energy machinery inside mitochondria.
Scientists have now sequenced the genome of a weird, single-celled organism called Naegleria gruberi that is telling biologists about that transition from prokaryotes, which function just fine with all their proteins floating around in a soup, to eukaryotes, which neatly compartmentalize those proteins?
A study into why some people are more resistant than others to diseases such as tuberculosis (TB) and leprosy has identified a new genetic variant which affects susceptibility to these diseases. The findings, published today in the journal Cell, may have implications for future treatments for the two conditions.
Current health care is not as safe as it should be. In the current issue of Deutsches Ärzteblatt International (Dtsch Arztebl Int 2010; 107[6]: 92-9), Barbara Hoffmann and Julia Rohe explain the reasons for adverse events, as well as measures to ensure better patient safety.
Patients with inflammatory bowel disease (IBD) suffer from chronic inflammation of the gut leading to gastrointestinal motility alterations with symptoms such as abdominal pain, cramps and diarrhea that profoundly affect their quality of life. The lack of exposure to worm infections, as a result of improved living standards and medical conditions, might have contributed to the increased incidence of IBD in the Western world. Epidemiological, experimental and clinical data support the idea that worm infection provides protection against IBD.
Cholangiocarcinoma (CCA), a bile duct cancer, is one of the major cancers in Northeast Thailand. This cancer is difficult to diagnose and has high metastatic and mortality rates. Overexpression of Met, a hepatocyte growth factor (HGF) receptor, has frequently been found in CCA and is correlated with progression of this type of cancer. HGF/Met activation induces a variety of cellular processes, including cell scattering, invasion and proliferation.
Tumor budding at the invasive tumor front of colorectal cancer is recognized as an independent prognostic factor significantly related to both lymph node and distant metastasis. Several lines of evidence seem to suggest that tumor buds may, to some extent, represent malignant colorectal cancer stem cells because of their potential for migration and re-differentiation locally and at sites of metastasis.
To evaluate efficacy of Calculus Bovis compound preparation (ICCBco) in the treatment of lung lesions in portal hypertensive rabbits with schistosomiasis as the experimental animal model, a research group in China performed a randomized, double-blind, controlled trial to observe pathological changes and pathological effect mechanism of expression of fibronectin and laminin in the lung tissue of portal hypertensive rabbits with schistosomiasis.
LONDON—SeaWeb applauded the announcement by the United States that it will support a proposed international trade ban for endangered bluefin tuna, and the ocean conservation organization called for international support for 32 species of red and pink coral as well as for eight shark species proposed for similar protection. These unique and valued marine species will be the focus of the upcoming Convention on International Trade in Endangered Species (CITES) Conference of Parties (CoP15), in Doha, Qatar, March 13 to 25.
Online social networks could help with communications and recovery for people with disabilities following major natural disasters, or even terrorist attack, according to a research paper in the International Journal of Emergency Management.
Hamilton, ON (March 4, 2010) — For some Canadians, any cut such as from dental work or surgery can cause days or more of bleeding. Although they are not hemophiliacs, for some an ordinary bruise can balloon into the size of an orange. For others, knees, elbows and ankles are crippled when bleeding seeps into joints. In very serious cases, hundreds of blood transfusions are required for recovery.
Heidelberg, 4 March 2010 – The thousands of bacteria, fungi and other microbes that live in our gut are essential contributors to our good health. They break down toxins, manufacture some vitamins and essential amino acids, and form a barrier against invaders. A study published today in Nature shows that, at 3.3 million, microbial genes in our gut outnumber previous estimates for the whole of the human body.
Psychosurgery is making a comeback. Recently published case series have shown encouraging results of so-called deep brain stimulation (DBS) in treatment-resistant obsessive-compulsive disorder, depressive disorders, and Tourette syndrome. In the current issue of Deutsches Ärzteblatt International, authors Jens Kuhn (University of Cologne) and Theo P J Gründer (Max Planck Institute, Cologne) and their co-authors provide an introduction to the method (Dtsch Arztebl Int 2010; 107(7)105-13).
Agricultural Research Service (ARS) scientist Scott Yates is studying how oxytetracycline (OTC), an antibiotic that is administered to animals, breaks down in cattle manure.
Livestock producers in the United States often use antibiotics to control disease in their animals, and confined U.S. livestock and poultry generate about 63.8 million tons of manure every year. The drugs are often only partially absorbed by the digestive tract, and the rest are excreted with their pharmaceutical activity intact.
ALBANY, Calif., March 1, 2010—New research addressing climate change questions, a priority focus of the USDA Forest Service Pacific Southwest Research Station, documents that American pika in the Sierra Nevada and southwestern Great Basin are thriving and persist in a wider range of temperatures than previously discovered.