LA JOLLA, CA – May 7, 2010 – In findings that advance scientists' understanding of a whole class of inherited disorders, a team from The Scripps Research Institute has shed light on a mechanism that enables a potential treatment for Gaucher's disease and other lysosomal storage diseases.
The findings were published in an advance, online edition of the journal Nature Chemical Biology on May 9, 2010.
Drinking even large amounts of coffee and sugar-sweetened, carbonated soft drinks is not associated with the risk of colon cancer according to a large study published online May 7 in the Journal of the National Cancer Institute.
(PHILADELPHIA) Researchers in the Department of Biochemistry and Molecular Biology at Thomas Jefferson University have found that the level of a single protein in the tiny roundworm C. elegans determines how long it lives. Worms born without this protein, called arrestin, lived about one-third longer than normal, while worms that had triple the amount of arrestin lived one-third less.
BOSTON, Mass. - Within cells, an ancient antiviral duo can deliver a one-two knockout to thwart invading viruses, report researchers who have just unmasked the cellular sidekick that throws the first punch. The findings mean scientists must rethink the design of antiviral immunity and how the body fends off viruses of all types, including influenza and HIV.
Vertebral fractures are the most common of all osteoporotic fractures and can have a devastating impact on a person's quality of life.
Research presented today at the World Congress on Osteoporosis 2010 (IOF WCO-ECCEO10) from the ongoing ICUROS study gave an indication of the early results of quality of life effects in relation to vertebral fractures.
Interestingly, patients who were hospitalised as a result of their vertebral fractures had a significantly larger quality of life reduction, than non-hospitalised patients.
CINCINNATI—Post-transplant patients who have been removed from a corticosteroid regimen have fewer cardiovascular events than those patients on steroids, increasing their graft survival rates and reducing early mortality, according to study results being presented this week by University of Cincinnati (UC) transplantation researchers.
Researchers with the division of transplantation and department of internal medicine are presenting the work at the American Transplant Congress (ATC), the annual meeting of the American Society of Transplantation, held May 1-5 in San Diego.
Love handles, muffin tops and stomach tires – white fat tissue forms the typical curves in the notorious problem areas to store energy. Exactly the opposite happens in brown fat tissue: Instead of being stored, energy gets transformed into heat. To the dismay of many people, adults have only small amounts of this energy burner. By contrast, babies and animals in hibernation have lots of it in their bodies where it serves for heat regulation.
Abstract 35P: Markers for risk of pregnancy-associated breast cancerC.B. Agborsangaya, FINLANDAs women delay child-birth to the third and fourth decades, the incidence of pregnancy-associated breast cancer is expected to rise. This paper suggests that identification of p53 autoantibody-positive pregnant women may be useful in predicting outbreak or early detection of pregnancy-associated breast cancer.
Chemical changes in the genetic material, known as epigenetic modifications, regulate the activity of many genes. Thus, attachment of methyl groups to DNA often inactivates important cellular growth brakes. Therefore, this process called methylation is believed to be a major cause of uncontrolled division of cancer cells. Specific enzymes, the DNA methyltransferases, are responsible for methylation.
PHILADELPHIA, May 7, 2010 -- A survey conducted by the American College of Physicians (ACP) and the American Board of Internal Medicine (ABIM) found that 9 percent of all internists originally certified between 1990 and 1995, including a significantly larger proportion of general internists (17 percent) than internal medicine subspecialists (4 percent), are no longer working in general internal medicine or one of its subspecialties about a decade after their original certification by ABIM.
Colorectal cancer (CRC) is one of the major causes of cancer death in the developed countries. Accumulated evidences indicate that lipid metabolism, especially the one in the arachidonic acid (AA)-pathway, appears to play a critical role in the development of CRC. The peroxisome proliferator-activated receptor-γ(PPAR-γ) gene, one of the most important components of the AA-pathway, has been verified to express in a variety of tumor cells. Many studies have been performed about the association between the polymorphism 34 C>G of PPAR-γgene and CRC, but got conflicting results.
Hepatocellular carcinoma (HCC) is the most common primary neoplasm of the liver and often arises in the context of a chronic liver disease that impairs coagulative function. Surgical resection is the best option to cure HCC, however, surgery on cirrhotic liver may increase the risk of bleeding. Despite the clinical relevance of the matter, no guidelines are available on the administration of antithromboembolic prophylaxis in cirrhotic patients undergoing hepatic resection.
Eradication of Helicobacter pylori (H. pylori) is a well-accepted initial therapy incases of localized (stage ⅠE) low-grade gastric mucosa-associated lymphoidtissue (MALT) lymphoma associated with H. pylori infection. However, there are no treatment guidelines for the management of H. pylori-negative low-grade gastric MALT lymphoma.
Recently, contrast-enhanced (CE) ultrasound (US) appeared as an important modality to show the vascularity in the areas of interest, and has been used widely in clinical diagnosis of liver lesions. Three dimensional ultrasonography (3D US) allows three orthogonal planes to spatially demonstrate the features of subjects, which has been frequently used in fetal US.
A team from the University of Cantabria (UC) has studied the contribution that internal migration by foreign people living in Spain made to the process of overall provincial convergence between 1996 and 2005. The main reasons for foreign migrants moving between regions were found to be primarily employment-related rather than to do with residential choice.