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Researchers at Mount Sinai School of Medicine have developed a new gene therapy that is safe and effective in reversing advanced heart failure. SERCA2a (produced as MYDICAR®) is a gene therapy designed to stimulate production of an enzyme that enables the failing heart to pump more effectively. In a Phase II study, SERCA2a injection through a routine minimally invasive cardiac catheterization was safe and showed clinical benefit in treating this patient population and decreasing the severity of heart failure.

Every minute, 10,000 gallons of water mysteriously gush out of the desert floor at a place called Ash Meadows, an oasis that is home to 24 plant and animal species found nowhere else in the world.

A new Brigham Young University study indicates that the water arriving at Ash Meadows is completing a 15,000-year journey, flowing slowly underground from what is now the Nevada Test Site.

The U.S. government tested nuclear bombs there for four decades, and a crack in the Earth's crust known as the "Gravity Fault" connects its aquifer with Ash Meadows.

A new therapy mounts a double-barreled attack on leukemia, targeting not just the cancer cells but also the environment in which those cells live and grow, University of Florida researchers report.

Like striking an enemy camp directly as well as cutting off its source of food and other resources, the agent, called Oxi4503, poisons leukemia cells and destroys the blood vessels that supply them with oxygen and nutrients.

In recent years, the Internet has been evolving from a primarily publication platform to a user participatory platform. With the proliferation of services available on the Internet, millions of users are able to voluntarily participate in the development of their own interests and benefits by means of service composition. However, due to the ever increasing number of services, enabling users to rapidly select and access these services has become a challenging issue.

PASADENA, Calif.—Biologists at the California Institute of Technology (Caltech) have pinpointed molecular changes that helped allow the global spread of resistance to the antiviral medication Tamiflu (oseltamivir) among strains of the seasonal H1N1 flu virus.

The study—led by David Baltimore, Caltech's Robert Andrews Millikan Professor of Biology and recipient of the 1975 Nobel Prize in Physiology or Medicine, and postdoctoral scholar Jesse D. Bloom—appears in the June 4 issue of the journal Science.

Some species of bacteria perform an amazing reproductive feat. When the single-celled organism splits in two, the daughter cell - the swarmer - inherits a propeller to swim freely. The mother cell builds a stalk to cling to surfaces.