Body

HPV infection heightens the risk of developing certain skin cancers and is worsened if people are taking immunosuppression drugs, according to a new study published on bmj.com today.

An international team of researchers found that people with several types of human papillomaviruses (HPVs) were more than one and a half times as likely to develop certain skin cancers compared to people with no HPVs.

Individuals with a high resting heart rate and a low beat-to-beat heart rate variability have an increased risk of developing kidney disease, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). The findings suggest that the behavior of the autonomic nervous system may be a sentinel marker for late development of certain cases of kidney disease.

Researchers have discovered a monoclonal antibody that is effective against "Avian" H5N1, seasonal H1N1 and the 2009 "Swine" H1N1 influenza. Scientists at Sea Lane Biotechnologies, LLC, in collaboration with Mt. Sinai School of Medicine, St. Jude Research Hospital and the Scripps Research Institute, have shown that this antibody potently prevents and treats the Swine H1N1 influenza in mouse models of the disease. Results are published July 8 in the open-access journal PLoS Pathogens.

As the mercury rises outdoors, it's a fitting time to consider the effects of summertime droughts and global warming on ecosystems. Complex interactions among temperature, water cycling, and plant communities create a tangled web of questions that need to be answered as we face a rapidly changing climate.

A specific and remarkably small fragment of RNA appears to protect rats against cocaine addiction—and may also protect humans, according to a recent study funded by the National Institute on Drug Abuse (NIDA), a component of the National Institutes of Health. The study was published today in the journal Nature.

Having discovered a dramatic increase of an easy-to-detect enzyme in the red blood cells of people with diabetes and prediabetes, Johns Hopkins scientists say the discovery could lead to a simple, routine test for detecting the subtle onset of the disease, before symptoms or complications occur and in time to reverse its course.

Patients with a certain type of scleroderma may get cancer and scleroderma simultaneously, Johns Hopkins researchers have found, suggesting that in some diseases, autoimmunity and cancer may be linked.

These findings could lead researchers closer to discovering what causes scleroderma, an incurable autoimmune disease that causes scar tissue to develop in the skin and in major organ systems, and to pinning down why some with scleroderma appear to be at increased risk of cancer. The insights add to the growing body of evidence linking some autoimmune disorders with cancer.

WASHINGTON – Children and adolescents who lack social problem-solving skills are more at risk of becoming bullies, victims or both than those who don't have these difficulties, says new research published by the American Psychological Association. But those who are also having academic troubles are even likelier to become bullies.

A Science article published on July 9, 2010, describes the discovery of an alternative form of evolution that helps Drosophila flies conquer nematodes that sterilize them. Nematodes are among the most abundant, diverse and destructive parasites of plants and animals.

CAMBRIDGE, Mass. (July 8, 2010) – Researchers at Whitehead Institute and Children's Hospital Boston have identified a protein, called Musashi 2, that is predictive of prognosis in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) patients.

High levels of Musashi 2 protein is associated with increased cell proliferation, decreased cell maturation, and multiple cancer-related cellular pathways in human leukemias.

KINGSTON, R.I. July 8, 2010 – A new system for the controlled delivery of pharmaceutical drugs has been developed by a team of University of Rhode Island chemical engineers using nanoparticles embedded in a liposome that can be triggered by non-invasive electromagnetic fields.

The discovery by URI professors Geoffrey Bothun and Arijit Bose and graduate student Yanjing Chen was published in the June issue of ACS Nano.

 New dinosaur species named for flamboyant frill

New Haven, Conn. — When Nicholas Longrich discovered a new dinosaur species with a heart-shaped frill on its head, he wanted to come up with a name just as flamboyant as the dinosaur's appearance. Over a few beers with fellow paleontologists one night, he blurted out the first thing that came to mind: Mojoceratops.

DURHAM, NC – Men who have a baseline PSA value of 10 or higher the first time they are tested are up to 11 times more likely to die from prostate cancer than are men with lower initial values, according to Duke University Medical Center researchers.

Scientists say the finding, appearing early online in the journal Cancer, supports routine, early prostate-specific antigen (PSA) screening among healthy men with normal life expectancy – a practice several studies have recently questioned.

Researchers from Mount Sinai School of Medicine have identified a previously unknown mechanism by which cells direct gene expression, the process by which information from a gene is used to direct the physical and behavioral development of individuals. The research, which may help scientists gain insight into how muscle and heart diseases develop, is published in the July 8th issue of Nature.

Using a small molecule decoy, investigators funded by the Samuel Waxman Cancer Research Foundation have managed to block protein interactions and induce epigenetic reprogramming in human and mouse breast cancer cells, essentially changing the gene expression of breast cancer cells to behave in a more normal manner. The research illustrates what may perhaps become an effective targeted epigenetic therapy in breast cancer.