BOSTON, Mass.—With the potential to save tens of thousands of lives each year, a new cost-effective rabies therapy developed by MassBiologics at the University of Massachusetts and the Serum Institute of India took an important step forward with positive results from a Phase 1 study. The recently completed study showed that a new monoclonal antibody (RAB-1) resulted in protective antibody levels in the serum of treated subjects equal to the current standard of treatment, which is often not available in the areas of the world hit hardest by rabies.
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Antibiotics can work miracles, knocking out common infections like bronchitis and tonsillitis. But according to the Center for Disease Control, each year 90,000 people in the U.S. die of drug-resistant "superbugs" ― bacteria like Staphylococcus aureus (MRSA), a deadly form of staph infection resistant to normal antibiotics. Although hospital patients are particularly susceptible as a result of open wounds and weakened immune systems, the bacteria can infect anyone.
Scientists have for the first time estimated the physical footprint of human activities on the deep seafloor of the North East Atlantic. The findings published in the journal PLoS ONE reveal that the area disturbed by bottom trawling commercial fishing fleets exceeds the combined physical footprint of other major human activities considered.
Global fisheries, a vital source of food and revenue throughout the world, contribute between US$225-$240 billion per year to the worldwide economy, according to four new studies released today. Researchers also concluded that healthier fisheries could have prevented malnourishment in nearly 20 million people in poorer countries.
This first comprehensive, peer-reviewed estimate of the global economic contribution of fisheries was published online today in four papers as part of a special issue of the Journal of Bioeconomics.
The research, unveiled at a press conference today (14 September 2010), shows that the watercress compound is able to interfere with the function of a protein which plays a critical role in cancer development.
As tumours develop they rapidly outgrow their existing blood supply so they send out signals which make surrounding normal tissues grow new blood vessels into the tumour which feed them oxygen and nutrients.
The first randomized, placebo-controlled U.S. clinical trial to assess the use of bone marrow-derived mononuclear cells (BMC) in patients after a ST-elevation myocardial infarction (STEMI; severe heart attack) demonstrated a strong safety profile for this cell therapy, based on phase 1 results published in the September issue of the American Heart Journal.
RICHMOND, Va. (Sept. 14, 2010) – An international team of researchers has identified a risk gene for schizophrenia, including a potentially causative mutation, using genome-wide association data-mining techniques and independent replications.
"The high presence of microRNA 451 enhances the response to treatment with chemo-radiotherapy and increases the survival of patients with stomach cancer", explained Dr. Jesús García-Foncillas, chief researcher of the Pharmacogenomics Laboratory at the Applied Medical Research Centre (CIMA) and Director of Oncology at the University Hospital of Navarra. This was one of the results presented at the IV Congress of the Spanish Society for Pharmacogenetics and Pharmacogenomic, recently held at CIMA.
A record-breaking 429 White-shouldered Ibis Pseudibis davisoni have just been recorded in Cambodia, making the known global population much larger than previously thought. With so many birds remaining in the wild the chances of conservation success are greatly improved – welcome news for this Critically Endangered bird species.
PROVIDENCE, R.I. [Brown University] — Researchers at Brown University and Women & Infants Hospital have invented the first artificial human ovary, an advance that provides a potentially powerful new means for conducting fertility research and could also yield infertility treatments for cancer patients. The team has already used the lab-grown organ to mature human eggs.
Washington, D.C. (September 14, 2010) -- A new "on-chip" method for sorting and identifying bacteria has been created by biomedical engineers at Taiwan's National Cheng Kung University. The technique, developed by Hsien-Chang Chang, a professor at the Institute of Biomedical Engineering and the Institute of Nanotechnology and Microsystems Engineering, along with former graduate student I-Fang Cheng and their colleagues, is described in the AIP journal Biomicrofluidics.
Repairing small, seemingly benign holes in a child's heart may be more clinically important than previously thought, as dysfunction could be lurking out of sight. These are the findings from a study conducted by doctors and researchers at Nationwide Children's Hospital and the Ohio State University Medical Center examining a subset of the most common form of congenital heart disease, ventricular septal defect. The recently published study appears in the Journal of Molecular and Cellular Cardiology, the official journal of the International Society for Heart Research.
International Fertility Societies call for harmonization of cross-border reproductive care standards
"The IFFS's 'Surveillance 2010' report, compiled by Professor Ian Cooke and published on 14 September 2010, illustrates this for over 100 countries. The survey highlights how widely assisted reproductive technologies (ART) are being used and how different cultures are regulating services in different ways. In most countries there is no state or insurance support, so these services are costly and frequently beyond the reach of many families. In some countries access to donor gametes is denied or supply is limited.
COLUMBUS, Ohio – Researchers at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James) have identified an experimental agent that targets chronic lymphocytic leukemia and perhaps other proliferative disorders of lymphocytes.
Their study shows that the small-molecule inhibitor CAL-101 directly promotes cell death by apoptosis in chronic lymphocytic leukemia (CLL) cells and disrupts several external survival pathways needed for CLL cell viability and proliferation.
A lifestyle intervention incorporating exercise training and diet counseling in primary health care settings appears to improve quality of life among adults at moderate to high risk for heart disease and appears cost-effective compared to standard care, according to a report in the September 13 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.