Body

ROCHESTER, Minn. -- Mayo Clinic researchers and their international colleagues have discovered genetic variants that lead to severe arthritis for a subset of women when taking aromatase inhibitors to treat their breast cancer. This serious side effect is so painful that many women halt their lifesaving medication. The findings appear today in the online issue of Journal of Clinical Oncology.

DETROIT ¬¬– Genetic ancestry has no discernible influence on how African American patients with asthma respond to medication, according to a Henry Ford Hospital study.

Researchers found that improved lung function in patients after taking inhaled steroids was related to a series of baseline breathing function measures, not genetic ancestry. The study is published online at the Journal of Allergy & Clinical Immunology, http://www.aaaai.org/media/jaci/

STANFORD, Calif. - Add pine-bark extract to the list of dietary supplements that don't live up to their promises of improved health. A new study from the Stanford University School of Medicine shows that pine-bark extract had no effect in lowering blood pressure or reducing other risk factors for heart disease.

Senior author Randall Stafford, MD, PhD, said the findings are part of a growing body of evidence that antioxidant supplements don't improve heart function.

In about 40 percent of research participants undergoing medical imaging, radiologists may detect a tumor or infection unrelated to the study but that may be meaningful to the individual's health, according to a report in the September 27 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

An intensive lifestyle intervention appears to help individuals with type 2 diabetes lose weight and keep it off, along with improving fitness, control of blood glucose levels and risk factors for cardiovascular disease, according to a report in the September 27 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

Home-based exercises followed by voluntary home training seem to be associated with long-term effects on balance and gait (manner of walking), and may help protect high-risk, elderly women from hip fractures, according to a report in the September 27 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

Use of pine bark extract, at a dose of 200 milligrams per day, appears safe but did not improve risk factors for heart disease, according to a report in the September 27 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

Software downloaded during a routine office visit cuts the risk of inappropriate shocks by 50 percent for patients with implantable cardioverter defibrillators (ICD), according to research reported in Circulation: Journal of the American Heart Association.

Using data from more than 270,000 hospital stroke admissions, scientists have identified how to predict which patients are at greatest risk of dying in the hospital after stroke. Before their study, well validated models to predict in-hospital death risk after stroke were lacking, the researchers reported in Circulation: Journal of the American Heart Association.

STANFORD, Calif. - A new analysis suggests that broader statin use among adult patients may be a cost-effective way to prevent heart attack and stroke. The Stanford University School of Medicine study also found that using a popular test - a screening for high sensitivity C-reactive protein, or CRP - to identify patients who may benefit from statin therapy would be cost-effective, but only under certain scenarios.

Intelligence isn't the only thing that predicts how much education people get; family, culture, and other factors are important, too. A new study published in Psychological Science, a journal of the Association for Psychological Science, compares identical and fraternal twins in Minnesota and Sweden to explore how genetic and environmental factors involved in educational differ in countries with different educational systems. Family background can get an education even for people of low intelligence, the authors conclude—but helps much more in Minnesota, than in Sweden.

One approach to an HIV vaccine is to teach the immune system to recognize certain protein structures on the viral surface and produce antibodies that bind to those structures and neutralize HIV. A strategy for designing such a vaccine involves identifying the key viral surface structures, snipping them off and developing a method to present these fragments to the immune system. When some parts of the surface of HIV are removed, however, they change shape such that antibodies no longer recognize and bind to them.

RICHMOND, Va. (Sept. 27, 2010) – Virginia Commonwealth University School of Medicine and VCU Massey Cancer Center researchers have shown that the impotence drug Viagra, in combination with doxorubicin, a powerful anti-cancer drug, enhances its anti-tumor efficacy in prostate cancer while alleviating the damage to the heart at the same time.

ANN ARBOR, Mich.---The more complex a plant or animal, the more difficulty it should have adapting to changes in the environment. That's been a maxim of evolutionary theory since biologist Ronald Fisher put forth the idea in 1930.

But if that tenet is true, how do you explain all the well-adapted, complex organisms---from orchids to bower birds to humans---in this world?