Body

New Haven, Conn.—A team of Yale University scientists has engineered the cell wall of the Staphylococcus aureus bacteria, tricking it into incorporating foreign small molecules and embedding them within the cell wall.

Talk about a walk on the wild side: University of Notre Dame researcher Joshua Shrout is co-author of a new paper that shows that bacteria are capable of "standing up" and moving while vertical.

The way melanoma cells use the immune system to spread and develop into lung tumors may lead to a therapy to decrease development of these tumors, according to Penn State researchers.

"Melanoma is the most aggressive and metastatic form of skin cancer," said Gavin Robertson, professor of pharmacology, pathology, dermatology and surgery in the Penn State College of Medicine. "Therefore, identifying proteins and molecular mechanisms that regulate metastasis is important for developing drugs to treat this disease."

Transgenic corn's resistance to pests has benefitted even non-transgenic corn, a new study led by scientists from the University of Minnesota shows.

Humans are overloading ecosystems with nitrogen through the burning of fossil fuels and an increase in nitrogen-producing industrial and agricultural activities, according to a new study. While nitrogen is an element that is essential to life, it is an environmental scourge at high levels.

According to the study, excess nitrogen that is contributed by human activities pollutes fresh waters and coastal zones, and may contribute to climate change. Nevertheless, such ecological damage could be reduced by the adoption of time-honored sustainable practices.

LA JOLLA, CA – October 4, 2010 – Researchers have determined the structure of a protein that helps guide blood-forming stem cells, or hematopoetic stem cells. The protein is also one of the main receptors used by the human immunodeficiency virus (HIV) to get inside blood cells.

The findings are described in the October 7, 2010 issue of the journal Science.

Study details structure of potential target for HIV and cancer drugs

While a molecule called CD4 is the primary receptor for HIV, CD4 is not sufficient for the virus to penetrate cells. In 1996, a team of researchers at NIH's National Institute of Allergy and Infectious Diseases (NIAID) discovered that CXCR4 acts as a co-receptor by helping HIV enter cells.

MADISON – Widespread planting of genetically modified Bt corn throughout the Upper Midwest has suppressed populations of the European corn borer, a major insect pest of corn, with the majority of the economic benefits going to growers who do not plant Bt corn, reports a multistate team of scientists in the Oct. 8 edition of the journal Science.

Cell survival protein discovery rewrites immune system story

A discovery by Walter and Eliza Hall Institute researchers in Melbourne, Australia, reported in today's edition of Science, is set to rewrite a long-held belief about how the body's immune system establishes its memory.

A group of agricultural scientists reported in today's issue of the journal Science that corn that has been genetically engineered to produce insect-killing proteins isolated from the soil bacterium Bacillus thuringiensis (Bt) provides significant economic benefits even to neighboring farmers who grow non-transgenic varieties of corn.

AURORA, Colo. (Oct. 7, 2010)—In 2006, Dr. Shimya Yaminaka of Kyoto University in Japan set the stem cell and regenerative medicine research world on fire when he successfully transformed differentiated mouse skin cells into cells that looked and behave like embryonic stem cells. Embryonic stem cells, the subject of much controversy when used in research, have the ability to differentiate into any type of tissue.

Accurate duplication of genetic material and the faithful segregation of chromosomes are critical for cell survival. The initiation of DNA replication is linked both to cell cycle progression and chromatin organization. In plants, animals and other "eukaryotes," the assembly of a multi-protein complex called pre-replicative complex (preRC) is the first step in the initiation of DNA replication. As the name implies, origin recognition complex (ORC) proteins bind to origins of DNA replication. Subsequently, other components of preRC are assembled at these sites.

PROVIDENCE, R.I. [Brown University] — Seemingly healthy adults, if they were abused or neglected during childhood, may suffer physiological consequences decades later. In research published online last week by the journal Neuropsychopharmacology, a team led by psychiatrists at Brown University and Butler Hospital found that healthy adults who reported being mistreated as kids appear to have an elevated inflammatory response to stress compared to adults who had happier childhoods.

London, UK (October, 07, 2010) –Many scientists aspire to take control over the stem cell differentiation process, so that we can grow organs and implants perfectly matched to each patient in the future. Now research in the Journal of Tissue Engineering, published by SAGE-Hindawi, explains how engineering the topography on which stem cells grow, and the mechanical forces working on them, can be as powerful an agent for change as their chemical environment.

STANFORD, Calif. — A genetic marker touted as a predictor of coronary artery disease is no such thing, according to a study led by researchers at the Stanford University School of Medicine.

The massive international study, published online Oct. 7 in the Journal of the American College of Cardiology, assessed the predictive value of a leading genetic assay for risk of atherosclerosis.