Body

LA JOLLA, CA – November 16, 2010 – A team led by scientists at The Scripps Research Institute has solved the structure of one of the receptors that responds to the neurotransmitter dopamine. Although dopamine transmission is essential to normal brain functioning, the biological assembly of the molecules involved in this crucial neuronal interplay had not been known—until now.

The work was reported in the November 19, 2010, issue of the journal Science.

 Mechanism behind organ transplant rejection

UCLA researchers have pinpointed the culprit behind chronic rejection of heart, lung and kidney transplants. Published in the Nov. 23 edition of Science Signaling, their findings suggest new therapeutic approaches for preventing transplant rejection and sabotaging cancer growth.

It may have been 1 billion years since plants and animals branched apart on the evolutionary tree but down through the ages they have developed strikingly similar mechanisms for detecting microbial invasions and resisting diseases.

This revelation was arrived at over a period of 15 years by teams of researchers from seemingly disparate fields who have used classical genetic studies to unravel the mysteries of disease resistance in plants and animals, according to a historical overview that will appear in the Nov. 19 issue of the journal Science.

WASHINGTON, Nov. 18, 2010 — The latest episode in the American Chemical Society's (ACS) award-winning podcast series, "Global Challenges/Chemistry Solutions," focuses on development and successful initial tests of an inexpensive new filtering technology that kills up to 98 percent of disease-causing bacteria in water in just seconds without clogging.

Bacteria use 'toxic darts' to disable each other

(Santa Barbara, Calif.) –– In nature, it's a dog-eat-dog world, even in the realm of bacteria. Competing bacteria use "toxic darts" to disable each other, according to a new study by UC Santa Barbara biologists. Their research is published in the journal Nature.

Employee wellness programs have often been viewed as a nice extra, not a strategic imperative. But the data demonstrate otherwise, according to a team of researchers led by Leonard L. Berry of Texas A&M University, Ann M. Mirabito of Baylor University and William B. Baun of the University of Texas MD Anderson Cancer Center.

Their research shows that the return on investment on comprehensive, well-run employee wellness programs is impressive — sometimes as high as six to one.

Gene therapy for metastatic melanoma in mice produces complete remission

INDIANAPOLIS – A potent anti-tumor gene introduced into mice with metastatic melanoma has resulted in permanent immune reconfiguration and produced a complete remission of their cancer, according to an article to be published in the December 2010 issue of the Journal of Clinical Investigation. The online version is now available.

Many studies support the assertion that moderate drinking is beneficial when it comes to cardiovascular health, and for the first time scientists have discovered that a well-known molecule, called Notch, may be behind alcohol's protective effects. Down the road, this finding could help scientists create a new treatment for heart disease that mimics the beneficial influence of modest alcohol consumption.

YAOUNDÉ, Cameroon (19 November 2010) – A new study finds a lack of transparency and corruption are reducing the impact of an initiative in Cameroon that channels a portion of national timber levies to rural forest communities. The study highlights the challenges of using a climate change pact to do something similar in forested regions around the world.

New research reveals a clever strategy that enables a host organism to outsmart an invading bacterium by counteracting its efforts to suppress the innate immune response. The study, published by Cell Press in the November 24th issue of the journal Immunity, describes a mechanism by which an infected cell can quickly alert unsuspecting (and uninfected) neighboring cells that can join the fight, amplify the immune response and defeat the invader.

MADISON — For decades, scientists have been searching for the fundamental biological secrets of how eating less extends lifespan.

It has been well documented in species ranging from spiders to monkeys that a diet with consistently fewer calories can dramatically slow the process of aging and improve health in old age. But how a reduced diet acts at the most basic level to influence metabolism and physiology to blunt the age-related decline of tissues and cells has remained, for the most part, a mystery.

Boston, MA – A new poll from researchers at the Harvard School of Public Health (HSPH) and Knowledge Networks (KN) shows that many people with heart disease, diabetes or cancer believe the economic downturn is hurting their health and will have further negative impacts in the future. Many Americans with these illnesses face financial problems paying for medical bills in this economy. Most of these people do not believe the new national health care reform law (Patient Protection and Affordable Care Act 2010) will help them.

Vitamin D is somewhat of an unusual "vitamin," because it can be made in the body from sunlight and most foods do not contain vitamin D unless added by fortification. Synthesis of vitamin D in the body requires exposure to ultraviolet light and can be influenced by genetics, skin color, and sun exposure.

HOUSTON – (Nov. 18, 2010) – Discovery of a fifth gene defect and the identification of 47 DNA regions linked to thoracic aortic disease are the subject of studies released this month involving researchers at The University of Texas Health Science Center at Houston (UTHealth).