Using a generic drug to treat hypertension and heart failure, instead of branded medicines from the same class, could save the UK National Health Service (NHS) at least £200 million in 2011 without any real reduction in clinical benefits.
That is the key finding of a systematic review, statistical meta-analysis and cost-effectiveness analysis just published online by IJCP, the International Journal of Clinical Practice.
The genes that make up the human genome were mapped by HUGO, the Human Genome Organisation, and published in 2001. Now the project is expanding into the HUPO, the Human Proteome Organisation. Within the framework of this organisation, many hundreds of researchers around the world will work together to identify the proteins that the different genes give rise to in the human body.
University of Manchester scientists have shown that a protein involved in blood clotting can be used to diagnose and subsequently monitor the treatment of a group of childhood genetic diseases.
In the study, published in the Journal of Inherited Metabolic Disease, the researchers were able to show that the clotting agent, heparan cofactor II/Thrombin (HCII/T) complex, could be used as a 'biomarker', or biological tell, in individuals with mucopolysaccharide (MPS) diseases.
Camden, N.J., February 3, 2011– Studies show drinking V8® 100% vegetable juice may be a simple way for people to increase their vegetable intake and may help them manage their weight – two areas of concern outlined in the newly released 2010 U.S. Dietary Guidelines for Americans.1
CHAMPAIGN, Ill. — Researchers have discovered the 100 million-year-old ancestor of a group of large, carnivorous, cricket-like insects that still live today in southern Asia, northern Indochina and Africa. The new find, in a limestone fossil bed in northeastern Brazil, corrects the mistaken classification of another fossil of this type and reveals that the genus has undergone very little evolutionary change since the Early Cretaceous Period, a time of dinosaurs just before the breakup of the supercontinent Gondwana.
MBL, WOODS HOLE, MA—The ubiquitous freshwater "water flea," Daphnia pulex, may be too small to see, but it has amply proven its value as an "sentinel species" for the presence of toxins and pollutants in the environment.
Daphnia's response to exposure to toxic metals and other chemical pollutants is well studied, and this information is routinely used by groups such as the US Environmental Protection Agency (EPA) to define regulatory limits, and to monitor industrial and municipal discharges.
Cancer researchers have discovered that a type of regulatory RNA may be effective in fighting ovarian cancer. Ovarian cancer isn't typically discovered until it's in the advanced stages, where it is already spreading to other organs and is very difficult to fight with chemotherapy. This new discovery may allow physicians to turn back the clock of the tumor's life cycle to a phase where traditional chemotherapy can better do its job.
ATLANTA – The American College of Rheumatology today announced the release of two new provisional definitions of rheumatoid arthritis remission, which are to be applied to future RA clinical trials.
According to research presented in the March issue of Arthritis & Rheumatism, a person with RA who is enrolled in a clinical trial would need to meet one of the following definitions to be considered in remission:
Training community birth attendants in rural Zambia in a simple newborn resuscitation protocol reduced neonatal deaths by nearly 50 percent – a finding that shows high potential to save lives in similar remote settings, a team of Boston University School of Public Health [BUSPH] international health researchers is reporting.
WASHINGTON — A new, detailed record of rainfall fluctuations in ancient Mexico that spans more than twelve centuries promises to improve our understanding of the role drought played in the rise and fall of pre-Hispanic civilizations.
Prior evidence has indicated that droughts could have been key factors in the fates of major cultures in ancient Mexico and Central America (Mesoamerica). But there have been many gaps in the paleoclimate record, such as the exact timing and geographic extension of some seemingly influential dry spells.
(WASHINGTON, February 3, 2011) – For blood cancer patients at high risk of relapse, hematopoietic stem cell transplantation (HSCT), the transplantation of blood-forming stem cells, is one of best options for treatment and a potential cure. Unfortunately, the most common complication of HSCT is graft-versus-host disease (GVHD), a serious and often deadly post-transplant complication that occurs when the newly transplanted donor cells recognize the recipient's own cells as foreign and react by attacking the cells in the patient's body.
The Gerontological Society of America (GSA) — the nation's largest interdisciplinary organization devoted to the field of aging — commends the federal government's recent release of the "2010 Dietary Guidelines for Americans" and particularly applauds its inclusion of specific advice for older adults.
OAK RIDGE, Tenn. Feb. 3, 2011 -- Researchers at the Department of Energy's Oak Ridge National Laboratory have developed a biohybrid photoconversion system -- based on the interaction of photosynthetic plant proteins with synthetic polymers -- that can convert visible light into hydrogen fuel.
CORVALLIS, Ore. – Scientists are having a difficult time gauging the recovery of marine species from the Deepwater Horizon oil spill in the Gulf of Mexico because they lack sufficient data about historical population size and the distribution, growth rates and reproduction rates of many species.
In a forum paper published this week in the journal Science, they call for a new research agenda that prioritizes systematic acquisition of baseline data for marine species.
Bar Harbor, Maine — Researchers at Dana-Farber Cancer Institute in Cambridge, Mass., in collaboration with Jackson Laboratory scientists, have identified a regulatory defect that drives lupus.