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The benefit and harm of positron emission tomography (PET) in patients with head and neck tumours, applied alone or in combination with computed tomography (CT), cannot currently be reliably assessed. This is the result of a final report published by the German Institute for Quality and Efficiency in Health Care (IQWiG). The Institute was commissioned by the Federal Joint Committee (G-BA) to assess the advantages and disadvantages of this diagnostic method. However, as the authors of the report explain, suitable studies for this purpose are lacking.

LOS ANGELES (April 28, 2011) – Scientists at Cedars-Sinai Medical Center have discovered how a molecular receptor on the surface of white blood cells identifies when invading fungi have established direct contact with the cell surface and pose an infectious threat.

JUPITER, FL, April 28, 2011 – Working with a group of national and international researchers, scientists from the Florida campus of The Scripps Research Institute have developed a new genetic model of premature aging disorders that could shed light on these rare conditions in humans and provide a novel platform for large-scale screening of compounds to combat these and other age-related diseases.

Injecting a tissue spacer in the prostate-rectal inter-space is an effective way to reduce the rectal dose for prostate cancer patients receiving radiation therapy, according to research presented April 30, 2011, at the Cancer Imaging and Radiation Therapy Symposium in Atlanta. This symposium is sponsored by the American Society for Radiation Oncology (ASTRO) and Radiological Society of North America (RSNA).

A pelvic MRI scan with IV contrast and rectal balloon is highly effective in identifying local recurrence even at low PSA values in prostate cancer patients with a rising or persistently elevated PSA after prostatectomy, according to a study presented April 29, 2011, at the Cancer Imaging and Radiation Therapy Symposium in Atlanta. The symposium is co-sponsored by the American Society for Radiation Oncology (ASTRO) and the Radiological Society of North America (RSNA).

An annual mammogram is sufficient follow-up after breast conserving therapy (BCT) for breast cancer patients, according to a study presented today, at the Cancer Imaging and Radiation Therapy Symposium in Atlanta. This symposium is co-sponsored by the American Society for Radiation Oncology (ASTRO) and Radiological Society of North America (RSNA).

Combining computerized tomography (CT) with fluorodeoxyglucose positron emission tomography (FDG-PET) images results in significantly more defined tumor outlines and potentially different treatment options in head and neck cancer patients compared to using CT alone, according to research presented today, at the Cancer Imaging and Radiation Therapy Symposium in Atlanta. This symposium is co-sponsored by the American Society for Radiation Oncology (ASTRO) and the Radiological Society of North America (RSNA).

3D models, produced by combining a patient's CT scans and 3D printing technology are proving useful in neurosurgical planning.

3D printing technology is a fast and affordable way to build 3D models for neurosurgical planning. Radiologists are able to transform ultra high-resolution CT patient images into 3D solid models using a 3D color printer commonly used in architecture, engineering and construction.

[EMBARGOED FOR APRIL 29, 2011] The U.S. measles vaccination program has been successful in eliminating endemic measles in the United States; yet this success has provided challenges that require ongoing vigilance for the rapid identification and response to measles cases in health care settings. In 2008, the largest reported health care-associated measles outbreak in the United States since 1989 occurred in Tucson, Arizona, costing approximately $800,000 in response and containment efforts.

Declining rates of hospitalization have discouraged primary care doctors from seeing their patients in the hospital and encouraged the growing use of "hospitalists," a new physician specialty focused on the care of hospitalized patients. Further developments in the field mean that frequently hospitalized patients also may need a specialist focused on their care, according to an expert on hospital care at the University of Chicago.

Many older adults may be taking "excessive" doses of drugs for thyroid problems which can lead to an increased risk of fractures, finds a study published on bmj.com today.

The study raises concern that treatment targets may need to be modified in the elderly and that regular dose monitoring remains essential even into older age.

Levothyroxine is a synthetic form of thyroxine (thyroid hormone) and is widely used to treat an underactive thyroid gland (hypothyroidism).

Potential molecular targets of the anti-HIV drug nelfinavir have been identified, and may explain why the drug is also effective as a cancer therapy. Findings will be published in the open-access journal PLoS Computational Biology on 28th April 2011.

Getting vaccinated against the flu lowers kidney transplant recipients' risk of organ loss and death, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). The results suggest that concerns about the safety of the influenza vaccine in transplant recipients are unwarranted.

The angiotensin-converting enzyme (ACE) inhibitor drug, ramipril, is particularly effective in lowering the risk of end-stage renal disease (ESRD) in obese patients, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

"Obese patients with kidney disease progress more quickly towards renal failure compared to non-obese patients, and ramipril virtually abolishes this excess risk," comments Carmine Zoccali, MD (CNR-IBIM and Ospedali Riuniti di Reggio Calabria, Italy).

Researchers at the University of California, San Diego and Hunter College of the City University of New York (CUNY) have identified potential human molecular targets of the anti-HIV drug Nelfinavir, which may explain why the drug is also effective as a cancer therapy. Their study will be published in the online edition of PLoS Computational Biology on April 28.