A team of researchers have found that pre-existing malaria prevents secondary infection by another Plasmodium strain, the parasite responsible for malaria, by restricting iron availability in the liver of the host. This discovery will be published this Sunday, May 15, in Nature Medicine and has important implications for the management and prevention of malaria, a condition which affects millions of individuals worldwide.
Body
Gene expression is the process of converting the genetic information encoded in DNA into a final gene product such as a protein or any of several types of RNA. Scientists have long thought that the gene programs regulated by different physiological processes throughout the body are robustly pre-determined and relatively fixed for every specialized cell. But a new study by researchers from the University of California, San Diego School of Medicine reveals the unsuspected plasticity of some of these gene expression programs.
Scientists from The Scripps Research Institute have identified a class of compounds that could be a boon to basic research and drug discovery.
WASHINGTON — Long-term survival rates for patients with advanced prostate cancer suggest they can be good candidates for surgery, Mayo Clinic researchers have found. Their study found a 20-year survival rate for 80 percent of patients diagnosed with cancer that has potentially spread beyond the prostate, known as cT3 prostate cancer, and treated with radical prostatectomy, or surgery to remove the prostate gland. Previously, patients found to have cT3 prostate cancer were offered radiation or hormone treatment, but not radical prostatectomy.
Researchers at Johns Hopkins have identified a bacterium in field-caught mosquitoes that stops the development of Plasmodium falciparum, the parasite that causes malaria in humans. According to the Science study, the Enterobacter bacterium is part of the naturally occurring microbial flora of the mosquito's gut and kills the parasite by producing reactive oxygen species (or free radical molecules).
A comprehensive report based on the National Survey of Children's Health conducted by children's health researchers at Oregon Health & Science University and the Maternal and Child Health Bureau finds insurance duration, consistency and adequacy, and the corresponding access to health care, are lacking for many US children and have a detrimental effect on their health and well-being.
Researchers have identified characteristic patterns of molecules called microRNA in the blood of people with lung cancer that might reveal both the presence and aggressiveness of the disease, and perhaps who is at risk of developing it. These patterns may be detectable up to two years before the tumor is found by computed tomography (CT) scans. The findings could lead to a blood test for lung cancer.
There is no practical, economic way to build structures that could stand up to the savagery of EF5 tornadoes like those that ripped through the South in late April, experts say, but damage from lesser storms could be reduced by better building practices and better enforcement of existing codes.
Engineers investigating "listener fatigue"-- the discomfort and pain some people experience while using in-ear headphones, hearing aids, and other devices that seal the ear canal from external sound -- have found not only what they believe is the cause, but also a potential solution.
Dynamic chest compression occurs during spinal manipulation. While dynamic chest compression has been well studied in events such as motor vehicle collisions, chest compression forces have not been studied during chiropractic manipulation. In a study published online today in the Journal of Manipulative and Physiological Therapeutics, researchers quantified and analyzed the magnitude of chest compressions during typical as well as maximum chiropractic manipulation and have found them to be well under the threshold for injury.
New research shows that elevated levels of cardiac troponin T (cTnT) or I (cTnI) in patients who had angioplasty indicate a higher risk of all-cause mortality and long-term adverse events such as heart attack. Routine monitoring of these protein levels following nonemergent percutaneous coronary intervention (PCI) could improve long-term outcomes for these patients. Details of the analysis are available online in Catheterization and Cardiovascular Interventions, a peer-reviewed journal of The Society for Cardiovascular Angiography and Interventions.
Canadian investigators have shown that a species of ebolavirus from Zaire that is highly virulent in humans can replicate in pigs, cause disease, and be transmitted to animals previously unexposed to the virus. The findings are published in the Journal of Infectious Diseases and are now available online.
Aspergillus niger is an integral player in the carbon cycle, it possesses an arsenal of enzymes that can be deployed in breaking down plant cell walls to free up sugars that can then be fermented and distilled into biofuel, a process being optimized by US Department of Energy researchers. This well-understood fungal fermentation process that could inform the development of a biorefinery where organic compounds replace the chemical building blocks normally derived from petroleum.
Scientists have demonstrated the use of computational methods to design new antiviral proteins not found in nature, but capable of targeting specific surfaces of flu virus molecules. Such designer proteins may have diagnostic and therapeutic potential in identifying and fighting viral infections. The researchers created a protein that disabled the part of the 1918 pandemic flu virus involved in invading respiratory tract cells. It did so by preventing segment from reconfiguring. This same protein also disabled a similar section of an avian flu virus.
Much about autism is unknown, but researchers from the University of Rochester Medical Center (URMC) are working to learn more about the neurodevelopmental disorder and its most effective treatments. A team of researchers from URMC joins researchers from across the world in San Diego this week for the 10th annual International Meeting for Autism Research (IMFAR). Rochester researchers are presenting on complementary medicine-use rates, nutritional insufficiencies and how artificial food dye might affect children with autism.