An article in the current issue of Technology & Innovation, Proceedings of the National Academy of Inventors ™ reports on the bright future and enormous need for stem cell therapeutics that may offer hope for those suffering from debilitating and deadly diseases.
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June 8, 2011 – Researchers at Children's Hospital Boston have found a marker called ABCB5 that both tags a small proportion of cells within colorectal cancers and fuels resistance in those cells to standard treatments. The results indicate that eliminating ABCB5-expressing cells is crucial for successful colorectal cancer treatment, while adding to the growing body of evidence for a theory of cancer growth called the cancer stem cell hypothesis.
WASHINGTON, DC, June 8, 2011 — A new study in the June issue of the American Sociological Review found evidence of how businesses engage in regulatory arbitrage and make decisions about where to open stores based on states' regulatory policies. The study explored various states' right-to-work (RTW) laws and Walmart store openings from 1998 through 2005.
The study, published yesterday in the journal Ecology Letters, analyzed the species richness and the structure of their communities throughout the different regions of the European territory from the Ural Mountains to the Iberian Peninsula. The selection of this family of insects was motivated by their high dispersal ability and because their food sources (mainly cattle and sheep dung) are present throughout the continent.
Anyone with Internet access can generate online content and influence public opinion, according to popular belief. But a new study from the University of California, Berkeley, suggests that the social Web is becoming more of a playground for the affluent than a digital democracy.
Despite the proliferation of social media – with Twitter and Facebook touted as playing pivotal roles in such pro-democracy movements as the Arab Spring – the bulk of today's blogs, websites and video-sharing sites represent the perspectives of college-educated, Web 2.0-savvy users, the study says.
Researchers at National Jewish Health have discovered how to prime a second arm of the immune system to potentially boost influenza vaccine effectiveness. A combination of two adjuvants, chemicals used to boost the effectiveness of some vaccines, induced CD8, or killer, T cells to join antibodies in response to influenza infection. Since the killer T cells targeted a highly conserved protein that does not change from year to year, the adjuvant strategy suggests potential for a universal flu vaccine.
The mechanisms by which obesity leads towards metabolic co-morbidities, such as diabetes mellitus, are poorly understood and of great public health interest. A study led by Matej Orešič from VTT Technical Research Centre of Finland suggests that adaptation of fat cell membranes to obesity may play a key role in the early stages of inflammatory disorders.
A blood protein known as surfactant protein-D (SP-D), which is mainly synthesised in the lungs, has been described as "a good predictor" of cardiovascular disease following a large study in North America. Reporting the study online today in the European Heart Journal, the investigators said that circulating SP-D levels were clearly associated with CVD and total mortality in patients with angiographically diagnosed coronary artery disease independent of other well established risk factors (such as age, smoking, cholesterol and C-reactive protein levels).(1)
A new study into osteosarcoma - cancer of the bone - will use advances in genomic research and analysis to identify new genes that give rise to the condition and to create personalised blood tests for children and young adults with the condition. The study is funded by Skeletal Action Cancer Trust, SCAT.
It is hoped that the results of this new study will help doctors improve treatment of this difficult disease through better diagnosis and monitoring of this bone cancer.
In this week's PLoS Medicine, Ricardo Soares Magalhães and Archie Clements, from the University of Queensland, Brisbane, Australia, describe how they used national cross-sectional household-based demographic health surveys to map the distribution of anaemia risk in preschool-age children in Burkina Faso, Ghana, and Mali.
Using a combination of sophisticated modelling and statistical analyses, David Fisman and colleagues show that infection with influenza likely increases the incidence of invasive pneumococcal disease (IPD). It is feasible that infection with influenza increases the short-term risk of bacterial invasion in individuals already colonized with Streptococcus pneumoniae (which causes IPD) by increasing the permeability of the lining of the airways to the bacteria.
The mechanisms by which obesity leads towards metabolic co-morbidities, such as diabetes mellitus, are poorly understood and of great public health interest. A study led by Matej Orešič from VTT Technical Research Centre of Finland suggests that adaptation of fat cell membranes to obesity may play a key role in the early stages of inflammatory disorders.
A 10-month study of healthy honey bees by University of California, San Francisco scientists has identified four new viruses that infect bees, while revealing that each of the viruses or bacteria previously linked to colony collapse is present in healthy hives as well.
The study followed 20 colonies in a commercial beekeeping operation of more than 70,000 hives as they were transported across the country pollinating crops, to answer one basic question: what viruses and bacteria exist in a normal colony throughout the year?
GALVESTON, Texas — A universal influenza vaccine targeting a protein common to all strains of influenza A has safely produced an immune response in humans. If proven effective, the vaccine could eliminate the practice of creating a new flu vaccine annually to match predicted strains, with major implications for global health.
As warm weather arrives and the great outdoors beckons, more and more men and women will be taking to the trails, the beaches, or their yards and gardens, embarking on physical activities that may result in sore, aching, swollen joints. While it may be tempting to ignore these aches and pains or treat them with a little over-the-counter liniment, a wiser choice is to visit a physician who can determine if the symptoms are due to bursitis, inflammation of the fluid-filled bursae, or sacs, that surround and cushion the joints.