Washington, DC (July 29, 2011) — For the thousands of patients who receive kidney transplants in the United States each year, preventing organ rejection without compromising other aspects of health requires a delicate balance of medications. Immunosuppresive drugs that protect transplanted organs can also cause serious side effects, including compromising patients' immunity to infection, cancer, and other threats. Finding the best combination and dosage of drugs has often proved difficult for physicians.
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The introduction of legislation that restricts unhealthy food, for example by reducing salt content and eliminating industrial trans fats, would prevent thousands of cases of heart disease in England and Wales and save the NHS millions of pounds, finds research published on bmj.com today.
Heart disease and stroke cause over 150,000 deaths every year in the UK and yet over 80% of premature heart disease is avoidable, say the authors.
Telomeres, the complex structures that protect the end of chromosomes, of peripheral blood cells are significantly shorter in patients with familial breast cancer than in the general population. Results of the study carried out by the Human Genetics Group of the Spanish National Cancer Research Centre (CNIO), led by Javier Benitez, to be published in open-access journal PLoS Genetics on July 28th, reflect that familial, but not sporadic, breast cancer cases are characterized by shorter telomeres.
The number of multiresistant strains of bacteria in hospitals is increasing. Bacteria acquire resistance to antibiotics through mutations in their chromosomes and by incorporating new genes, either from the surrounding environment or from other bacteria. Now, a research team at the Portuguese CBA research (University of Lisbon) and the Instituto Gulbenkian de Ciência has shown that, surprisingly, when both mechanisms of resistance are playing out in the bacterium Escherichia coli (E. coli), its ability to survive and reproduce is increased.
Hamilton, ON (July 28, 2011) – It's not fair, but it's true. A new study by researchers at McMaster University has found that some ethnic groups are more likely to be adding dangerous fat onto their internal organs like their liver when they gain weight, while others just add it to their waistline.
Dr. Sonia Anand, who led the study published today in the medical journal PLoS ONE, said South Asians are particularly more likely to add the type of organ-hugging fat that can lead to diabetes and coronary artery disease.
The stroke rate for pregnant women and those who recently gave birth increased alarmingly over the past dozen years, according to research reported in Stroke: Journal of the American Heart Association.
Researchers gathered data from a large national database of 5 to 8 million discharges from 1,000 hospitals and compared the rates of strokes from 1994-95 to 2006-07 in women who were pregnant, delivering a baby and who had recently had a baby.
Pregnancy-related stroke hospitalizations increased 54 percent, from 4,085 in 1994-95 to 6,293 in 2006-07.
GAINESVILLE, Fla. — In the last 30 years, more than 90 percent of the reef-building coral responsible for maintaining major marine habitats and providing a natural barrier against hurricanes in the Caribbean has disappeared because of a disease of unknown origin.
SEATTLE – Using a "systems biology" approach – which focuses on understanding the complex relationships between biological systems – to look under the hood of an aggressive form of breast cancer, researchers for the first time have identified a set of proteins in the blood that change in abundance long before the cancer is clinically detectable. The findings, by co-authors Christopher Kemp, Ph.D., and Samir Hanash, M.D., Ph.D., members of Fred Hutchinson Cancer Research Center's Human Biology and Public Health Sciences divisions, respectively, are published online ahead of the Aug.
Every year, plant diseases wipe out millions of tons of crops, lead to the waste of valuable water resources and cause farmers to spend tens of billions of dollars battling them.
Now a new discovery from a University of North Carolina at Chapel Hill-led research team may help tip the war between plants and pathogens in favor of flora.
The researchers discovered that a rainforest vine, pollinated by bats, has evolved dish-shaped leaves with such conspicuous echoes that nectar-feeding bats can find its flowers twice as fast by echolocation. The study is published today in Science.
While it is well known that the bright colours of flowers serve to attract visually-guided pollinators such as bees and birds, little research has been done to see whether plants which rely on echolocating bats for pollination and seed dispersal have evolved analogous echo-acoustic signals.
Researchers funded by the Biotechnology and Biological Sciences Research Council (BBSRC) have opened up the black box of plant immune system genetics, boosting our ability to produce disease- and pest-resistant crops in the future. The research is published this evening (28 July) in the journal Science.
BOSTON ––– The eon-spanning clock of evolution – the millions of years that generally pass before organisms acquire new traits – belies a constant ferment in the chambers and channels of cells, as changes in genes and proteins have subtle ripple effects throughout an organism. In a study in the July 29 issue of Science, scientists at Dana-Farber Cancer Institute's Center for Cancer Systems Biology and an international team of colleagues capture the first evidence of the evolutionary process within networks of plant proteins.
Powerful new technologies that zoom in on the connections between human genes and diseases have illuminated the landscape of cancer, singling out changes in tumor DNA that drive the development of certain types of malignancies such as melanoma or ovarian cancer.
Now several major biomedical centers have collaborated to shine a light on head and neck squamous cell cancer. Their large-scale analysis has revealed a surprising new set of mutations involved in this understudied disease.
New research sheds light on why, after 300,000 years of domination, European Neanderthals abruptly disappeared. Researchers from the University of Cambridge have discovered that modern humans coming from Africa swarmed the region, arriving with over ten times the population as the Neanderthal inhabitants.
Science usually progresses in small steps, but on rare occasions, a new combination of research expertise and cutting-edge technology produces a 'great leap forward.' An international team of scientists, whose senior investigators include Salk Institute plant biologist Joseph Ecker, report one such leap in the July 29, 2011 issue of Science. They describe their mapping and early analyses of thousands of protein-to-protein interactions within the cells of Arabidopsis thaliana -a variety of mustard plant that is to plant biology what the lab mouse is to human biology.