A mobile workforce can help improve a country's economy but the effects of commuting on the health of commuters and on the costs to industry in terms of sick days is largely unknown. From a commuter's point of view, the advantages of daily travel, such as a better paid job or better housing conditions, need to be weighed against adverse health effects. New research published in BioMed Central's open access journal BMC Public Health shows that commuting by car or public transport, compared to walking or cycling, is associated with negative effects on health.
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PHILADELPHIA, PA (October 30 2011)—In a technical tour de force, scientists at Fox Chase Cancer Center have cataloged and cross-indexed the actions of 178 candidate drugs capable of blocking the activity of one or more of 300 enzymes, including enzymes critical for cancer and other diseases. Additionally, a free library of the results has been made available online to the research community. This unique library represents an important new tool for accelerating the development of an entire class of targeted cancer drugs.
A large pad of fat cells that extends from the stomach and covers the intestines provides nutrients that promote the spread and growth of ovarian cancer, reports a research team based at the University of Chicago in the journal Nature Medicine, published online October 30th, 2011.
SEATTLE – An international team of researchers led by investigators in the U.S. and Germany has shed light on the inner workings of the endocycle, a common cell cycle that fuels growth in plants, animals and some human tissues and is responsible for generating up to half of the Earth's biomass. This discovery, led by a geneticist at Fred Hutchinson Cancer Research Center and reported Oct. 30 in Nature, leads to a new understanding of how cells grow and how rates of cell growth might be increased or decreased, which has important implications in both agriculture and medicine.
PHILADELPHIA - The most common form of heritable cognitive impairment is Fragile X Syndrome, caused by mutation or malfunction of the FMR1 gene. Loss of FMR1 function is also the most common genetic cause of autism. Understanding how this gene works is vital to finding new treatments to help Fragile X patients and others.
The human genome has been mapped. Now, it's on to proteins, a much more daunting task. There are 20,300 genes, but there are millions of distinct protein molecules in our bodies. Many of these hold keys to understanding disease and targeting treatment.
A team led by Northwestern University chemical biologist Neil Kelleher has developed a new "top-down" method that can separate and identify thousands of protein molecules quickly. Many have been skeptical that such an approach, where each protein is analyzed intact instead of in smaller parts, could be done on such a large scale.
SAN FRANCISCO, CA—October 30, 2011—Scientists at the Gladstone Institutes have discovered how a form of the protein linked to Huntington's disease influences the timing and severity of its symptoms, offering new avenues for treating not only this disease, but also a variety of similar conditions.
NEW YORK (Oct. 28, 2011) -- Researchers at Weill Cornell Medical College say they have taken an important step forward in their quest to "turn on" lung regeneration -- an advance that could effectively treat millions of people suffering from respiratory disorders.
Individual beliefs don't stay confined to the person who has them; they can affect how a society functions. A new study published in Psychological Science, a journal of the Association for Psychological Science, looks at 57 countries and finds that an individual's sexism leads to gender inequality in the society as a whole—not surprising, but it is the largest study to find this relationship.
NUT midline carcinoma (NMC) is a cancer without a cure, and one that affects all age groups. NMC is a rapid-growth disease with an average survival time of four and a half months after diagnosis, making the development of clinical trials for potential therapies or cures for this cancer difficult, to say the least.
Worldwide, there are more than 1.5 billion overweight adults, including 400 million who are obese. In Australia, it is estimated more than 50 per cent of women and 60 per cent of men are either overweight or obese. Although restriction of diet often results in initial weight loss, more than 80 per cent of obese dieters fail to maintain their reduced weight.
After 70 years, antibiotics are still the primary treatment for halting the spread of bacterial infections. But the prevalence of antibiotic resistance is now outpacing the rate of new drug discovery and approval.
A microbiologist at the University of Wisconsin-Milwaukee (UWM) has discovered a different approach: Instead of killing the bacteria, why not disarm them, quashing disease without the worry of antibiotic resistance?
Worcester, Mass. -- With scientific evidence now supporting the age-old wisdom that cranberries, whether in sauce or as juice, prevent urinary tract infections, people have wondered if there was an element of the berry that, if extracted and condensed, perhaps in pill form, would be as effective as drinking the juice or eating cranberry sauce. A new study from researchers at Worcester Polytechnic Institute (WPI) helps to answer that question.
ANTWERP – Scientists found a deadly parasite with some of its chromosomes in duplicate, others in triplicate, while still others are present four or even five times. Moreover, the copy number varies between individuals. Such a bizarre occurrence has never before been found in nature, in any organism. As a rule, chromosomes should come in couples. The scientists, from the Institute of Tropical Medicine (ITG) and the Wellcome Trust Sanger Institute, made the striking discovery while deciphering the genetic code of a series of Leishmania-parasites.
BOSTON -- Even yeast understand austerity. A finely tuned system evolved early on to help cells survive in a world where good times come as fast as they go. The system, a molecular switch found in organisms from yeast to humans, involves a nutrient-sensing protein that turns growth on in times of plenty and shuts it off when times are lean.