Scientists at the MaxDelbrück Center for Molecular Medicine in the Helmholtz Association (MDC) and the Leibniz-Institut für Molekulare Pharmakologie (FMP) in Berlin, in cooperation with a Dutch group, have now succeeded in showing that the volume-regulated anion channel VRAC is 50 % responsible for active substance uptake. If one of the VRAC subunits LRRC8A or LRRC8D is down-regulated, cells take up considerably less of the anti-cancer drug. In addition to this finding, programmed cell death or apoptosis is also significantly disturbed when LRRC8A is missing.
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QUT scientists have discovered the gene that will open the door for space-based food production.
Professor Peter Waterhouse, a plant geneticist at QUT, discovered the gene in the ancient Australian native tobacco plant Nicotiana benthamiana, known as Pitjuri to indigenous Aboriginals tribes.
Professor Waterhouse made the discovery while tracing the history of the Pitjuri plant, which for decades has been used by geneticists as a model plant upon which to test viruses and vaccines.
WASHINGTON - Rates of military sexual trauma among men who served in the military may be as much as 15 times higher than has been previously reported, largely because of barriers associated with stigma, beliefs in myths about male rape, and feelings of helplessness, according to articles published by the American Psychological Association.
JUPITER, FL - Nov. 3, 2015 - A team led by scientists from the Florida campus of The Scripps Research Institute (TSRI) and the University of Pittsburgh has shown for the first time how one set of specialized cells survives under stress by manipulating the behavior of key immune system cells.
Older people with an age-related loss of muscle mass and strength may be at greater risk of falling and bone fractures, according to new research led by the University of Southampton.
A study by an international team of researchers into sarcopenia -where muscles lose form and function with age - found that those with the condition reported higher numbers of falls in the last year and a higher prevalence of fractures.
VERNON - Reducing greenhouse gas emissions in the Southern Great Plains could require a change of grazing management by traditional cow-calf producers, according to a study by Texas A&M AgriLife Research.
Adaptive multi-paddock grazing is an advanced, more efficient form of rotational grazing and is a potential option to reduce net greenhouse gas emissions, or GHG, on a cow-calf operation in the Southern Great Plains.
A DNA sample thought to show prehistoric trade in cereals is most likely from modern wheat, according to new research led by the Max Planck Institute for Developmental Biology.
THE more children a woman has or whether a woman has had her fallopian tubes cut lowers the risk of different types of ovarian cancer to different levels, according to new research* presented at the 2015 National Cancer Research Institute (NCRI) Cancer Conference today (Tuesday).
Data was collected from more than 8000 women with ovarian cancer as part of the UK Million Women Study.
Researchers then examined the risk of the four most common types of ovarian cancer - serous, mucinous, endometrioid and clear cell tumours - in women with different childbearing patterns.
A study of life and extinctions among woolly mammoths and other ice-age animals suggests that interconnected habitats can help Arctic mammal species survive environmental changes.
The study went online Nov. 2 in the Proceedings of the National Academy of Sciences "Early Edition."
HOUSTON - (Nov. 2, 2015) - Chagas disease -- the third most common parasitic infection in the world -- affects approximately 7.5 million people, mostly in Latin America. To help reduce outbreaks of this disease in their countries, the United States and Mexican governments should implement a range of programs as well as fund research for the development of Chagas vaccines and treatments, according to a new policy brief by tropical-disease and science policy experts at Rice University's Baker Institute for Public Policy.
Boston, MA - Two new studies from Harvard T.H. Chan School of Public Health shed light on critical dietary issues facing Americans. One study showed that while recent improvements in the U.S. diet have helped reduce disease and premature death, the overall American diet is still poor. Another, which analyzed interventions to reduce childhood obesity, found three that would save more in health care costs than they would cost to implement.
Both studies will be published November 2, 2015 in the November issue of Health Affairs.
To determine whether healthy food could help low-income people better control their diabetes, a pilot study by UC San Francisco and Feeding America tracked nearly 700 people at food banks in California, Texas and Ohio over two years.
The result: better diabetes control and medication adherence and an overall improvement in the consumption of healthy food.
West Nile virus is killing millions more birds and affecting many more bird species than previously thought, according to new research from a multi-university team of researchers.
Survival estimates dropped dramatically in populations exposed to West Nile virus for nearly half of the 49 bird species studied, the largest percentage of species yet found to be affected by the virus. Previous estimates have been closer to one-third of studied species. The research appears today in the Proceedings of the National Academy of Sciences.
A team of Massachusetts General Hospital (MGH) investigators has shown that a method they developed to improve the usefulness and precision of the most common form of the gene-editing tools CRISPR-Cas9 RNA-guided nucleases can be applied to Cas9 enzymes from other bacterial sources.
Researchers at University of the Pacific have developed a biochemical trick that can significantly extend the lifespan of peptides, smaller cousins of proteins. The finding opens up new possibilities for creating peptides to treat cancer, infertility and other conditions.
The research, led by Mamoun Alhamadsheh, assistant professor of pharmacy at Pacific, is featured in the November issue of Nature Reviews Drug Discovery, a publication that spotlights high-impact papers from Nature, Cell and other major scientific journals.