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Washington, DC — Blood pressure that remains elevated over of time — known as chronic hypertension — has been linked to heart disease, which is the leading cause of death in the United States. Recent research has shown that persistent high blood pressure may also increase the risk for stroke and overall mortality. Yet, only about 1 in 4 adults with chronic hypertension have their condition under control, according to the Centers for Disease Control and Prevention.
PITTSBURGH, Jan. 29, 2021 - A study led by UPMC Children's Hospital of Pittsburgh and the University of Pittsburgh School of Medicine shows that Black children are 18% less likely to get imaging tests as part of their emergency department visit compared to White children. Hispanic children are 13% less likely to have imaging done than Whites.
(Singapore--January 29, 2021 11:00 p.m. SPT/10:00 a.m. EST)--On February 27, 2020, the flagship journal of the International Association for the Study of Lung Cancer, the Journal of Thoracic Oncology, published a case study that described two patients from Wuhan, China who recently underwent lung lobectomies for adenocarcinoma and were retrospectively found to have had COVID-19 at the time of surgery.
(Singapore Embargoed for 7:23pm EST on January 29, 2021 to coincide with publication in the Journal of Clinical Oncology) -- Adding ipilimumab to pembrolizumab does not improve efficacy and is associated with greater toxicity than pembrolizumab alone as first-line therapy for metastatic non-small cell lung cancer (NSCLC) for patients with a PD-L1 tumor proportion score of greater than or equal to 50% and no targetable EGFR or ALK aberrations, according to research presented today at the International Association for the Study of Lung Cancer's World Conference on Lung Cancer.
What The Study Did: Maternally derived antibodies are a key element of neonatal immunity. This study examined the association between maternal and neonatal SARS-CoV-2-specific antibody concentrations because understanding the dynamics of maternal antibody responses to SARS-CoV-2 infection during pregnancy and subsequent transplacental antibody transfer can inform neonatal management as well as maternal vaccination strategies.
What The Study Did: Researchers investigated the association between county-level social risk factors and COVID-19 cases and deaths, as well as weekly changes in cumulative cases and mortality, using publicly available data sets as of July 29, 2020.
Authors: Renuka Tipirneni, M.D., M.Sc., of the University of Michigan in Ann Arbor, is th corresponding author.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
CHICAGO (January 29, 2021) -- Structural racism thwarts a large proportion of black patients from receiving appropriate lung cancer care, resulting in worse outcomes and shorter lifespans than white patients with the disease, according to research presented at the 57th Annual Meeting of The Society of Thoracic Surgeons.
In a study evaluating the BioNTech-Pfizer COVID-19 vaccine's ability to neutralize the B.1.1.7 ("UK") viral variant, researchers found no loss of immune protection compared to that against the original Wuhan reference strain. Their analysis was based on blood samples from 40 people who had received the BioNTech-Pfizer COVID-19 vaccine during clinical trials. The authors conclude their results show it is "unlikely that the UK variant virus will escape ... protection" as mediated by this vaccine. In September 2020, the SARS-CoV-2 lineage B.1.1.7 was discovered in the United Kingdom.
SORLA is a protein trafficking receptor that has been mainly studied in neurons, but it also plays a role in cancer cells. Professor Johanna Ivaska's research group at Turku Bioscience observed that SORLA functionally contributes to the most reported therapy-resistant mechanism by which the cell-surface receptor HER3 counteracts HER2 targeting therapy in HER2-positive cancers. Removing SORLA from cancer cells sensitized anti-HER2 resistant breast cancer brain metastasis to targeted therapy.
A combination of reduced-dose radiotherapy using intensity-modulated radiotherapy (IMRT) combined with concurrent cisplatin met the threshold for disease control and quality of life compared to the standard of care for good-risk patients with HPV-associated oropharyngeal squamous cell carcinoma on the NRG Oncology clinical trial NRG-HN002. The outcomes from this data justify the advancement of the reduced radiotherapy dose with cisplatin to a Phase III clinical trial setting in this population. These results were recently published in the Journal of Clinical Oncology.
Coronary artery calcification -- the buildup of calcified plaque in the walls of the heart's arteries -- is an important predictor of adverse cardiovascular events like heart attacks. Coronary calcium can be detected by computed tomography (CT) scans, but quantifying the amount of plaque requires radiological expertise, time and specialized equipment. In practice, even though chest CT scans are fairly common, calcium score CTs are not.
A new report combining forecasting and expert prediction data, predicts that 125,000 lives could be saved by the end of 2021 if 50% or more of the U.S. population initiated COVID vaccination by March 1, 2021.
(Singapore--4:45 p.m. SPT/3:45 a.m. EST January 30, 2021--Using a host immune classifier (HIC) test for patients with non-small cell lung cancer (NSCLC) may provide better predictors of treatment response and improve outcomes, according to research presented today at the International Association for the Study of Lung Cancer's 2020 World Conference on Lung Cancer Singapore.
Drawing on animal-foraging theory, a new model predicts psychological factors that may lead to panic buying during times of crisis. The model is largely supported by real-world data from the COVID-19 pandemic. Richard Bentall of the University of Sheffield, England, and colleagues presented these findings in the open-access journal PLOS ONE on January 27.
(Singapore--16:45 p.m. SPT/3:45 EST January 29, 2021)--Two presentations from the ADAURA clinical trial advanced previous research that demonstrated improved disease-fee survival (DFS) outcomes for patients with surgically resected non-small cell lung cancer (NSCLC) receiving osimertinib. The data were reported today at the International Association for the Study of Lung Cancer's 2020 World Conference on Lung Cancer (WCLC) Singapore.