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Researchers at the Lady Davis Institute have identified a key protein that is required for resistance to chemotherapy in the most aggressive form of breast cancer. This holds the promise of opening the door to new therapies for overcoming drug resistance.
Results from the NRG Oncology phase I clinical trial NRG-GOG 9929 show that utilizing the immunotherapy drug ipilimumab after chemoradiotherapy (CRT) is tolerated in the curative treatment of women with lymph node-positive cervical cancer. The maximum tolerated dose of ipilimumab was determined to be 10 mg/kg. These results are published in JAMA Oncology and was be highlighted at a gynecologic session during the American Society for Radiation Oncology's (ASTRO) Annual Meeting in September 2019.
CHICAGO - A novel MRI-guided procedure that uses therapeutic ultrasound effectively treats prostate cancer with minimal side effects, according to a new study presented today at the annual meeting of the Radiological Society of North America (RSNA). Researchers said the incision-free technique could also be used to treat benign enlargement of the prostate gland.
The investigational therapeutics mAb114 and REGN-EB3 offer patients a greater chance of surviving Ebola virus disease (EVD) compared to the investigational treatment ZMapp, according to published results from a clinical trial conducted in the Democratic Republic of the Congo (DRC). The new report also shows that early diagnosis and treatment are associated with an increased likelihood of survival from EVD.
Sophia Antipolis, 2 December 2019: Brushing teeth frequently is linked with lower risks of atrial fibrillation and heart failure, according to a study published today in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology (ESC).1
A major new analysis of the non-opioid medications, gabapentin and baclofen, shows "worrying" increases in related suicide attempts and hospital admissions in US adults since 2013 - coinciding with a decrease in opioid prescriptions.
MINNEAPOLIS - Researchers have identified nine cases of people who lost their ability to swim after having a deep brain stimulation device implanted to control symptoms of Parkinson's disease. The new research is published in the November 27, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology. All nine people had been good swimmers even after their Parkinson's disease diagnosis. But once they had deep brain stimulation surgery, researchers found while other movement symptoms improved, their swimming skills deteriorated.
HAMILTON, ON (November 27, 2019) - A study led by Hamilton researchers has found a new way to interpret blood test results in patients who are investigated for blood clots in their lungs, a condition known as pulmonary embolism.
This new approach applies to D-dimer blood tests, which are used by physicians to rule out the presence of a blood clot. Researchers found that a higher than usual D-dimer level can be considered a negative result if the physician has assessed the patient as having a low probability of having a pulmonary embolism.
Atrial fibrillation, also known as AFib, is the most common type of irregular heartbeat, and it is associated with increased mortality. While researchers have identified a causal link between obesity and AFib, the underlying mechanism of how obesity contributes to the heart arrhythmia is still unknown.
There are three treatment options commonly used by doctors in the emergency room to treat patients with refractory status epilepticus, severe seizures that continue even after benzodiazepine medications, which are effective in controlling seizures in more than two-thirds of patients. New findings published in the New England Journal of Medicine reveal that the three drugs, levetiracetam, fosphenytoin, and valproate, are equally safe and effective in treating patients with this condition.
Early use of breast milk could play a vital role in preventing heart disease in prematurely born infants, according to a paper led by researchers at RCSI (Royal College of Surgeons in Ireland) and the Rotunda Hospital.
The review article, published in the journal Pediatric Research, was written in collaboration with researchers from Harvard Medical School, University of Oxford and University of Toronto.
A group of researchers from the University of Seville and the Seville Biomedicine Institute (Instituto de Biomedicina de Sevilla - IBiS) has published a study in which they determine that a protein called CD44 makes it possible to identify the population of mother cells that are responsible for the aggressive nature and low survival rate of neuroblastoma, a type of childhood cancer that mainly affects children of two and three years old.
MALT1 blockers have long been in clinical use for the treatment of blood cancers. A study suggests that these drugs could potentially also be developed as a treatment option for glioblastoma, the most common and lethal type of brain tumour.
Heidelberg, 27 November 2019 - For a long time, cancer research has largely focused on so-called oncogenes - genes that can cause cancer when mutated. While targeting these genes has led to the successful development of a number of valuable drugs, this approach is hampered by the fact that tumours often become resistant to these treatments.
Scientists at the University of Surrey have developed a novel vaccine and complementary skin test to protect cattle against bovine tuberculosis (bovine TB).
Publishing their findings in the journal Scientific Reports, researchers reveal they have for the first time created a vaccine that is compatible with a synthetic form of the tuberculin skin test (PPD), a legally required test used for the surveillance of TB in cattle throughout the UK.
Head-to-head comparison finds three anti-seizure drugs equally effective for severe form of epilepsy
ANN ARBOR, Mich. - A new study finds that the three most common treatment options administered in the emergency department for patients who experience refractory status epilepticus are equally safe and effective.
Status epilepticus is characterized by individual seizures or multiple seizures close together lasting more than five minutes with a loss of consciousness. If not treated, it can lead to severe brain damage or death.