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Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent.

1. Dual therapy reduces risk for bleeding better than triple therapy for patients with atrial fibrillation undergoing PCI

ANN ARBOR, Mich. - While symptoms of appendicitis may be common, a new study suggests that accurately diagnosing the condition in the emergency department may be more challenging.

New Rochelle, NY, March 16, 2020--A new study of 1,365 racially/ethnically diverse, low-income pregnant women found that 4% reported e-cigarette use. White non-Hispanic women were more likely to use e-cigarettes compared to women who used conventional cigarettes or reported no tobacco product use, according to an article published in Journal of Women's Health, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers.

What The Study Did: This observational study looked at how common nonmedical prescription opioid use was among transgender girls and young women and risk factors associated with it.

Authors: Arjee J. Restar, M.P.H., of the Brown University School of Public Health in Providence, Rhode Island, is the corresponding author.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ 

(10.1001/jamanetworkopen.2020.1015)

Abdominal arterial (or aortic) aneurysm in older men is associated with levels of certain subtypes of white blood cells, a study from the University of Gothenburg, Sweden, shows. The study results belong to an expanding research field that is expected improve both knowledge of the disease and treatment options.

Fear is a major factor behind people's reluctance to take part in clinical research, such as trials to test new medicines and treatments, a global review has found.

In the UK, up to two thirds of trials currently fail to recruit their target number of participants for vital medical research.

The review, led by researchers at the University of York and Hull York Medical School, found that fear about testing new treatments and possible side effects was the most common reason given by patients for not wanting to participate.

Exercising can be a chore. We know it's good for us, and we may do it, but it's not always fun.

When training gets tough, finding something or someone that helps us get over that motivational hump can be just what we need. Researchers at the Norwegian University of Science and Technology (NTNU) have now tested how social media can help.

"We wanted to encourage and support people in feeling good about their training," says Professor Frode Stenseng at NTNU's Department of Education and Lifelong Learning.

ANN ARBOR--The use of opioids to soothe the pain of a pulled tooth could be drastically reduced or eliminated altogether from dentistry, say University of Michigan researchers.

If you've ever played an immersive game using virtual reality (VR) technology, you'll be familiar with the concept of customising an avatar to represent you. Most people design an aspirational, buffed-up version of themselves, but new research from the University of Bath suggests you should temper your vanity when the game is for fitness, as your performance improves when they compete against an avatar that more closely matches your authentic self.

In the first study of its kind, University of Miami researchers have found a strong behavioral signal to indicate which infants who have an older sibling with an autism spectrum disorder (ASD) will themselves be diagnosed with ASD as they grow older.

The researchers found that such high-risk infants who exhibit an early social difficulty, specifically an insecure-resistant attachment to a parent, are more than nine times more likely to receive an ASD diagnosis by age 3 than high-risk infants with secure attachments.

The cover for issue 10 of Oncotarget features Figure 3, "Overall survival (OS) for high (red) versus low (black) risk groups in the (A) OSU, (B) TCGA, and (C) SNU resected cohorts," by Wolfe, et al.

A team of researchers from Russia and Greece has shown a way to determine the origins and nature of quasar light by its polarization. The new approach is analogous to the way cinema glasses produce a 3D image by feeding each eye with the light of a particular polarization: either horizontal or vertical. The authors of the recent study in the Monthly Notices of the Royal Astronomical Society managed to distinguish between the light coming from different parts of quasars -- their disks and jets -- by discerning its distinct polarizations.

ROCHESTER, Minn. -- Mayo Clinic researchers have uncovered stem cell-activated mechanisms of healing after a heart attack. Stem cells restored cardiac muscle back to its condition before the heart attack, in turn providing a blueprint of how stem cells may work.

The study, published in NPJ Regenerative Medicine, finds that human cardiopoietic cells zero in on damaged proteins to reverse complex changes caused by a heart attack. Cardiopoietic cells are derived from adult stem cell sources of bone marrow.

STONY BROOK, NY, March 12, 2020 - A new study published in Scientific Reports reveals that the language people use on Facebook subtly changes before they make a visit to the emergency department (ED). A team of researchers in part led by H.