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The pediatric brain cancer known as diffuse intrinsic pontine glioma (DIPG) is almost uniformly fatal. In part, this is due to where and how it grows, forming as a diffuse net of cells in a part of the brainstem called the pons, which controls essential functions like breathing and swallowing. Another factor that makes DIPG especially dangerous is a lack of treatments - currently, there are no targeted therapies or immunotherapies proven effective to treat the condition, and the many chemotherapy clinical trials seeking to treat DIPG have been uniformly unsuccessful.
What The Viewpoint Says: Emerging as an acute infectious disease, COVID-19 may be- come a chronic epidemic similar to influenza because of genetic re- combination. Therefore, we should be ready for the reemergence of COVID-19 or other coronaviruses.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamacardio.2020.0934)
A medication commonly used to treat non-small cell lung cancer that has spread, or metastasized, may have benefits for patients with metastatic brain cancers, suggests a new review and analysis led by researchers at St. Michael's Hospital of Unity Health Toronto and Harvard Medical School.
Published today in JAMA Network Open, the research hones in on osimertinib, a treatment recently approved in North America as a therapy for metastatic non-small cell lung cancer with a specific mutation.
Denver--March 25, 2020-- Lung cancer clinical trials supported by the pharmaceutical industry demonstrate no more bias compared to studies funded by other sources, according to a study published in the Journal of Thoracic Oncology, the official journal of the International Association for the Study of Lung Cancer.
Clinical trials are expensive and often require funding from the pharmaceutical industry, but previous studies have revealed bias in clinical studies conducted by industry sponsors.
An international team of researchers led by the Universities of Bonn and Ulm has investigated how a cell's own "protein shredder" can be specifically programmed to fight cancer. The researchers were able to demonstrate the degradation of proteins that are overly active in breast cancer, for example. The results are published in the renowned journal "Chemical Science".
New Rochelle, NY, March 25, 2020--The need for accurate and informative labeling of hemp and hemp-derived cannabidiol (CBD) products is a critical public health issue. Despite CBD being a U.S. Food and Drug Administration-approved drug, it is increasingly being added to food, beverages, and nutritional supplements, often with misleading labeling or marketing claims, according to an article published in Cannabis and Cannabinoid Research, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.
Irvine, CA - March 25, 2020 - Researchers from the University of California, Irvine have conducted a statistical analysis that predicts more than 70,000 heart attacks, strokes and other adverse cardiovascular events could be prevented each year in the U.S. through the use of a highly purified fish oil therapy.
International surgical guidelines launched today (24/3 US - 25/3 UK) will help to save thousands of lives in Low- and Middle-income Countries (LMIC) countries by standardising and improving practice in surgery.
An international collaboration led by the University of Birmingham sets out nine essential recommendations that should be implemented as a priority across all hospitals world-wide in the fight against Surgical Site Infection (SSI).
Bottom Line: A HER2-targeted antibody-drug conjugate, fam-trastuzumab deruxtecan-nxki (Enhertu), showed signs of clinical activity in multiple non-breast/non-gastric cancer types, according to results from a phase I study.
Journal in Which the Study was Published: Cancer Discovery, a journal of the American Association for Cancer Research
New cases of hepatitis C amongst HIV positive men in London and Brighton have fallen by nearly 70 per cent in recent years.
An analysis of five clinics in London and Brighton found that 378 cases were diagnosed between July 2013 - June 2018. New infections peaked at 14 per 1000 people studied in 2015, falling to 4 per 1000 by 2018. The study is published in Clinical Infectious Diseases.
As COVID-19 spreads worldwide, leaders are relying on mathematical models to make public health and economic decisions.
A new model developed by Princeton and Carnegie Mellon researchers improves tracking of epidemics by accounting for mutations in diseases. Now, the researchers are working to apply their model to allow leaders to evaluate the effects of countermeasures to epidemics before they deploy them.
Joint research between Kobe University and National Hospital Organization Kyushu Cancer Center has revealed that mice with mutations in the YAP signal pathway develop head-and-neck cancer over an extremely short period of time (world's fastest cancer onset mouse model), indicating that this pathway plays a crucial role in the onset of these cancers. This discovery may shed light on the development of new drugs for head-and-neck cancer.
Infections are still responsible for one in five childhood deaths in England and Wales, with respiratory infections topping the league table of known causes, reveals an analysis of the most up to date figures, published online in Archives of Disease in Childhood.
This is despite sharp declines in overall childhood death rates over the past decade, helped in part by the introduction of new vaccination programmes, suggest the researchers.
The first study looking at the effect of chlorhexidine mouthwash on the entire oral microbiome has found its use significantly increases the abundance of lactate-producing bacteria that lower saliva pH, and may increase the risk of tooth damage.
A team led by Dr Raul Bescos from the University of Plymouth's Faculty of Health gave a placebo mouthwash to subjects for seven days, followed by seven days of a chlorhexidine mouthwash.
First of its kind modelling study in Singapore indicates that quarantining of people infected with the new coronavirus and their family members, school closures plus quarantine, and workplace distancing plus quarantine, in that order, are effective at reducing the number of COVID-19 cases, with a combination of all three being most effective in reducing cases