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HOUSTON - In an international trial led by researchers at The University of Texas MD Anderson Cancer Center, treatment with MK-6482, the small molecule inhibitor of hypoxia-inducible factor (HIF)-2a was well tolerated and resulted in clinical responses for patients with von Hippel-Lindau disease (VHL)-associated renal cell carcinoma (RCC).
The results of the Phase II trial were shared today in an oral presentation at the 2020 American Society of Clinical Oncology Annual Meeting by principal investigator Eric Jonasch, M.D., professor of Genitourinary Medical Oncology.
BOSTON--Researchers at Massachusetts General Hospital have uncovered an unexpected connection between an imbalance of electrons in liver cells and many metabolic problems that increase the risk for conditions such as cardiovascular disease and fatty liver disease. Their findings, published in the journal Nature, shine a light on the phenomenon known as reductive stress and how genetics and environmental factors such as diet influence this emerging disease risk factor.
Pairing a blood-thinning drug with aspirin daily for patients who have an angioplasty with a stent can contribute to better health outcomes, including lower risk of death, than aspirin alone, according to a recent study by cardiologists at the University of Alberta and Mazankowski Alberta Heart Institute.
Top stroke experts have issued new guidance to ensure stroke patients receive safe, timely care while preventing the transmission of COVID-19.
The guidelines urge the use of telemedicine to speed treatment and advise EMS crews how to determine the best facility to treat the patient's needs. The recommendations, from the American Heart Association's Stroke Council, come amid increasing concerns that stroke patients are delaying seeking care because of fear of COVID-19. Such delays can have catastrophic consequences, including death.
A team led by researchers at Baylor College of Medicine in collaboration with Medterra CBD conducted the first scientific studies to assess the potential therapeutic effects of cannabidiol (CBD) for arthritic pain in dogs, and the results could lead the way to studying its effect in humans. Researchers focused first on these animals because their condition closely mimics the characteristics of human arthritis, the leading cause of pain and disability in the U.S. for which there is no effective treatment.
Rehabilitation clinicians and other health care professionals now have a framework for assessing and managing people who may have serious spinal pathologies.
CHICAGO (May 27, 2020): As health care providers observe Coronavirus Disease 2019 (COVID-19) affecting children differently than adults, pediatric surgeons in Chicago have modified an evaluation tool for use in pediatric patients that allows surgeons in every pediatric specialty to prioritize nonemergency ("elective") operations during all phases of the pandemic.
A potential blood-based biomarker for Alzheimer's and other neurodegenerative diseases seems even more promising thanks to new research from a Massachusetts General Hospital-led study. According to this team's work, neurofilament light chain (NfL) has great potential as a biomarker for early detection of Alzheimer's disease and could be also useful for monitoring treatment response for that condition.
An analysis of the 2018-2019 measles outbreak in New York City--the largest such outbreak in the United States in nearly three decades--identifies factors that made the outbreak so severe: delayed vaccination of young children combined with increased contact among this age group, likely through "measles parties" designed to purposely infect children. The study by Wan Yang, PhD, assistant professor of epidemiology at Columbia University Mailman School of Public Health, has implications for the future, as vaccination rates plummet during the COVID-19 pandemic.
The ocean is a messy and turbulent space, where winds and weather kick up waves in all directions. When an object or person goes missing at sea, the complex, constantly changing conditions of the ocean can confound and delay critical search-and-rescue operations.
Now researchers at MIT, the Swiss Federal Institute of Technology (ETH), the Woods Hole Oceanographic Institution (WHOI), and Virginia Tech have developed a technique that they hope will help first responders quickly zero in on regions of the sea where missing objects or people are likely to be.
DALLAS, May 27, 2020 -- Women and minorities, particularly African Americans, continue to be inadequately represented in clinical trials for novel cardiometabolic medications, with no evidence of improvement in enrollment numbers over the past decade, according to new research published last week in the Journal of the American Heart Association, an open access journal of the American Heart Association.
Black non-Hispanic and Hispanic women with opioid use disorder (OUD) are significantly less likely to receive or to consistently use any medication to treat their opioid use disorder during pregnancy than their white non-Hispanic counterparts, according to a new study from Massachusetts General Hospital (MGH).
A study by University of Cincinnati researchers and four Italian institutions reviewing neuroimaging and neurological symptoms in patients with COVID-19 may shed light on the virus's impact on the central nervous system.
The findings, published in the journal Radiology, reveal that altered mental status and stroke are the most common neurological symptoms in COVID-19 patients, which authors say could help physicians notice "red flags" earlier.
CLEVELAND, Ohio (May 26, 2020)--Dairy products provide more bone-beneficial nutrients than any other food group. Yet a new study based on data from the Study of Women's Health Across the Nation (SWAN) shows that during the menopause transition, when bone loss is accelerated, they offer little benefit in preventing bone mineral density loss or fractures. Study results are published online in Menopause, the journal of The North American Menopause Society (NAMS).
The novel coronavirus pandemic has caused an increased demand for antimicrobial treatments that can keep surfaces clean, particularly in health care settings. Although some surfaces have been developed that can combat bacteria, what's been lacking is a surface that can also kill off viruses. Now, researchers have found a way to impart durable antiviral and antibacterial properties to an aluminum alloy used in hospitals, according to a report in ACS Biomaterials Science & Engineering.