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Vienna, Austria, June 18, 2020 - AFFiRiS AG, a clinical-stage biotechnology company developing novel disease-modifying specific active immunotherapies (SAITs), today announced that detailed results of the phase 1 clinical program with its lead candidate PD01 in early Parkinson's disease (PD) patients were published in the peer-reviewed journal The Lancet Neurology.
Patients with cancer face a serious dilemma during the COVID-19 pandemic, as staying at home could increase their risk of cancer progression, while visiting the hospital for treatment could increase their risk of becoming infected with the virus that causes COVID-19. A new study published in Psycho-Oncology reveals how the pandemic has impacted such patients' quality of life.
Researchers at a major Boston academic medical center designed, fabricated, tested, and implemented a reusable face shield for front-line medical staff within a couple of weeks. The work, presented June 18 in the journal Med, was carried out at the Brigham and Women's Hospital Emergency Department in collaboration with members of the volunteer group Greater Boston Pandemic Fabrication Team (PanFab) and the local maker community.
A study of nearly 400 pregnant women in New York City is among the first to show that lower neighborhood socioeconomic status and greater household crowding increase the risk of becoming infected with SARS-CoV-2, the virus that causes COVID-19.
DETROIT -A Henry Ford Hospital study published in the Journal of Arthroscopic and Related Surgery, has found that patients who underwent knee surgery and other types of sports medicine procedures could manage their pain without opioids or a minimal dosage.
Madison, WI (June 18, 2020): In a paper published online this week in Autism Research, scientists at NeuroPointDX, a division of Stemina Biomarker Discovery, Inc., in collaboration with researchers at the UC Davis MIND Institute and academic and clinical institutions across the country, report new findings from the Children's Autism Metabolome Project or CAMP.
A multi-institutional group of researchers led by Harvard Medical School and the Novartis Institutes for BioMedical Research has created an open-source machine learning tool that identifies proteins associated with drug side effects.
The work, published June 18 in the Lancet journal EBioMedicine, offers a new method for developing safer medicines by identifying potential adverse reactions before drug candidates reach human clinical trials or enter the market as approved medicines.
A sequencing pipeline that integrates a patient's specific tumor genetic data boosts the sensitivity of tests that detect cancer cell DNA circulating in the blood, according to a newly published study. The platform could routinely detect hard-to-spot circulating tumor DNA (ctDNA) on the order of one mutant molecule per 100,000 in plasma samples from 105 patients with various cancers. Although further work is needed, the test represents a stride in creating a ctDNA assay sensitive enough to be used in the clinic to monitor cancers.
Combining more healthy lifestyle behaviors was associated with substantially lower risk for Alzheimer's disease in a study that included data from nearly 3,000 research participants. Those who adhered to four or all of the five specified healthy behaviors were found to have a 60% lower risk of Alzheimer's. The behaviors were physical activity, not smoking, light-to-moderate alcohol consumption, a high-quality diet, and cognitive activities.
Slightly less than half (48%) of New Yorkers know how vaccines actually work, but those who do are about 7% more likely to say they will take a COVID-19 vaccine when one becomes available. Knowledge apart, however, 81% of those New Yorkers who have seen the symptoms of COVID-19 in their own households say they are likely to accept a vaccine.
East Hanover, NJ. June 17, 2020. Researchers at Kessler Foundation conducted a comprehensive review of pharmacologic agents used in the treatment of multiple sclerosis, seeking evidence for efficacy for the cognitive dysfunction experienced by more than half of affected individuals. The article, "Cognitive efficacy of pharmacologic treatments in multiple sclerosis: A systematic review," was published open access in CNS Drugs 2020 May 02.
A research group from Kumamoto University, Japan, has clarified the mechanism by which human T-cell leukemia virus type 1 (HTLV-1) causes inflammation and oncogenesis. The action of the viral gene HTLV-1 bZIP factor (HBZ) changes the reactivity of immune cells (T cells) infected with HTLV-1 to cytokines, which results in inflammation.
What The Study Did: Researchers examined what demographic and clinical factors are associated with the decision to withdraw life-supporting treatment in patients with severe traumatic brain injury using data from more than 825 trauma centers in the U.S.
Authors: Theresa Williamson, M.D., of Duke University Medical Center in Durham, North Carolina, is the corresponding author.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
What The Study Did: Whether the prone position is associated with improved oxygenation and decreased risk for intubation in spontaneously breathing patients with severe COVID-19 hypoxemic respiratory failure is investigated in this observational study.
Authors: Sanja Jelic, M.D., of the Columbia University Vagelos College of Physicians and Surgeons in New York, is the corresponding author.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
Kilchberg/Switzerland: Disease-related, profound fatigue impairs the quality of life of many people with rheumatic and musculoskeletal diseases. A Belgian study (1) has now concluded that early intensive treatment combining methotrexate with a bridging scheme of prednisone can reduce the onerous fatigue - this also applies to patients at low risk of a severe course. The European League against Rheumatism (EULAR) therefore recommends, that even in so-called low-risk patients, early consideration should be given to whether intensive treatment should be initiated.