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ATLANTA -- New research presented at ACR Convergence, the American College Rheumatology's annual meeting, showed that patients with rheumatic diseases whose infliximab treatment was individually assessed and adjusted with a new strategy called therapeutic drug monitoring did not achieve remission at higher rates compared to those who received standard care.
ATLANTA -- New research presented at ACR Convergence, the American College of Rheumatology's annual meeting, identified key clinical features of chronic nonbacterial osteomyelitis (CNO), which leads to an important step toward the development of much-needed classification criteria for a disease that affects children and young adults worldwide (ABSTRACT #1162).
New research reveals that tinnitus, a common condition that causes the perception of noise in the ear and head, is being exacerbated by COVID-19 - as well as the measures helping to keep us safe.
The study of 3,103 people with tinnitus was led by Anglia Ruskin University (ARU), with support from the British Tinnitus Association and the American Tinnitus Association. The study involved participants from 48 countries, with the vast majority coming from the UK and the US.
What The Study Did: The implementation of swab screening program for COVID-19 cancer patients prior to each cycle of anticancer therapy at a hospital in the United Arab Emirates was assessed in this study.
Authors: Humaid O. Al-Shamsi, M.D., of the Burjeel Oncology-Burjeel Medical City in Abu Dhabi, United Arab Emirates, is the corresponding author.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamaoncol.2020.5745)
What The Study Did: Researchers compared the rate of death for patients diagnosed with breast, colorectal or lung cancer and living in states that expanded Medicaid under the Patient Protection and Affordable Care Act with states that didn't.
Authors: Miranda B. Lam, M.D., M.B.A., of the Harvard T.H. Chan School of Public Health in Boston, is the corresponding author.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
SAN DIEGO - Nov. 5, 2020-- A vast majority of doctors and parents of babies in intensive care, with diseases of unknown origin, believe genomic sequencing is beneficial in managing care, according to two new papers published by Rady Children's Institute for Genomic Medicine.
The study examined the attitudes of parents and physicians of infants admitted to neonatal intensive care at Rady Children's Hospital-San Diego about their perceptions of the usefulness of applying genomic testing in search of a diagnosis.
Governments should consider incentivising people to get a COVID-19 jab, when the vaccine becomes available, to achieve the required level of herd immunity--which could be up to 80%+ of the population--and stamp out the infection, argues a leading ethicist in an opinion piece accepted for publication in the Journal of Medical Ethics.
The incentive could be either financial or 'payment in kind', such as being allowed to forego the need to wear a facemask in public, he suggests.
Angiogenesis is the process by which tumors create new blood vessels that will provide them the nutrients to continue growing. Antiangiogenic drugs specifically block this process. This type of therapy usually has good short-term results, reducing tumor growth. However, several studies suggest that these treatments increase the invasiveness of tumors, and promote more aggressive behavior, inducing a poor prognosis. Studies with animal models have attempted to decipher the molecular mechanisms involved in this discrepancy, but many questions remain unclear.
SASKATOON - A new University of Saskatchewan (USask) study has found that exercise performance and blood and muscle oxygen levels are not affected for healthy individuals wearing a face mask during strenuous workouts.
Questions have been raised as to whether mask wearing during vigorous exercise might compromise oxygen uptake or increase the rebreathing of carbon dioxide, leading to a condition (hypercapnic hypoxia) whereby increased carbon dioxide displaces oxygen in the blood.
A research team led by Professor Hongzhe SUN, Chair Professor from the Department of Chemistry, Faculty of Science, in collaboration with Dr Pak-Leung HO, Director of the HKU Carol Yu Centre for Infection from the Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong (HKU) discovers that by repurposing an antirheumatic gold drug, auranofin (AUR), "last-resort" antibiotics can be resensitized for treatment of infections caused by multidrug-resistant superbugs including bloodstream infections, pneumonia and wound infections.
UNIVERSITY PARK, Pa. -- Strength training is an important part of any exercise routine, but some women may not be getting the recommended hours. New Penn State research discovered some of the barriers preventing women from strength training, as well as some solutions to overcoming those obstacles.
National Institutes of Health researchers have discovered a gene in mice that controls the craving for fatty and sugary foods and the desire to exercise. The gene, Prkar2a, is highly expressed in the habenula, a tiny brain region involved in responses to pain, stress, anxiety, sleep and reward. The findings could inform future research to prevent obesity and its accompanying risks for cardiovascular disease and diabetes.
Pancreatic cancer is highly lethal: according to the National Cancer Institute, only about 10 percent of patients remain alive five years after diagnosis. Now, a preclinical study from the lab of Marsha Moses, PhD at Boston Children's Hospital, reports marked and lasting tumor regression in a mouse model, using a highly selective, potent, engineered antibody-drug combination.
The findings, published November 3 in the journal Advanced Science, provide the basis for further pre-clinical studies to advance this approach to the clinic, the researchers say.
Predicting the course of a COVID-19 patient's disease after hospital admission is essential to improving treatment. Brigham and Women's Hospital researchers analyzed patients' levels of inflammation, known to be associated with severity of illness, by looking at C-reactive protein (CRP) trends in 100 COVID-19 patients admitted to the hospital. They found that a rapid rise in CRP levels during the first 48-to-72 hours of hospitalization was predictive of subsequent respiratory deterioration and intubation, while steadier CRP levels were observed in patients whose condition remained stable.
MUSC Hollings Cancer Center researchers identified that blocking an alternative energy pathway for T-cells after hematopoietic stem cell transplant helps reduce graft-versus-host disease (GVHD) in an animal model of leukemia.
Xue-Zhong Yu, M.D., who also is associate director of Basic Science at Hollings, and collaborators at the Indiana University School of Medicine discovered that donor T-cells must have the key enzyme lysosomal acid lipase in order to induce GVHD.