CLEVELAND: Researchers from University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine will present data from several new studies, including a study that built an online tool used to estimate individualized survival for patients with newly diagnosed glioblastoma (GBM), at the 52nd American Society for Clinical Oncology (ASCO) Annual Meeting in Chicago. ASCO 2016, held June 3-7, will be attended by 30,000 oncology professionals from around the world.
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CHICAGO--The targeted therapy rucaparib, which has demonstrated robust clinical activity in ovarian cancer patients with a BRCA mutation, also showed promise in previously treated pancreatic cancer patients with the mutation, according to results from a phase II clinical study presented by Susan M. Domchek, MD, executive director of the Basser Center for BRCA at the Abramson Cancer Center of the University of Pennsylvania, at the American Society of Clinical Oncology (ASCO) Annual Meeting.
TAMPA, Fla. (June 4, 2016) - Patients with recurrent high-grade glioma brain tumors have few effective treatment options and the majority of available therapies do not improve survival. Moffitt Cancer Center will present preliminary results from a phase 1 study testing whether the addition of pembrolizumab to radiation therapy and bevacizumab is safe and can control tumor growth for these patients. The findings will be discussed Saturday, June 4, during the American Society of Clinical Oncology Annual Meeting in Chicago.
A video related to this research can be found here: https://youtu.be/170ceT_dvcE
FLAGSTAFF, Ariz. -- June 1, 2016 -- A fungal infection associated with a high percentage of deaths among HIV and other immune-compromised patients is more diverse than previously known and likely spread around the world by bats.
A global assessment of the fungus Histoplasma by the Translational Genomics Research Institute (TGen) found that the pathogen is actually divided among six species, and that its spread and speciation from continent-to-continent over the past 9 million years coincides with the global dispersal and evolution of bats.
A new study from The Australian National University (ANU) has found a global boom in the sale of infant and baby formula, especially in China and Southeast Asia, raising concerns about the health of millions of mothers and their babies.
Lead researcher Dr Phillip Baker said the study suggested governments around the world needed to do more to control marketing of baby formula and to ensure work policies gave women a choice to breastfeed their children.
Nagoya, Japan -- Across the centuries, forming cooperative networks beyond cultural boundaries has been a way to overcome natural disasters.
A Nagoya University researcher and his leading international research group discovered a Great Platform built with different kinds of stone at the archeological site of San Andrés, El Salvador, and challenged the prevailing theory regarding the sociocultural development of Southeastern Maya frontier.
Aligning minimum wages with fair ('living') wages could generate further positive productivity effects and slash the number of working poor, Australian and British researchers have found.
A new study challenges the common industry position that introducing a national living wage in excess of minimum wage levels would result in an excessive cost burden, significant job losses and no guarantee of future productivity growth.
Two new research papers on scabies and tapeworms published today in the Open Access journal GigaScience also include a collaboration with protocols.io. This collaboration showcases a new way to share scientific methods that allows scientists to better repeat and build on these complicated studies on difficult-to-study parasites. It also highlights a new means of writing all research papers with citable methods that can be updated over time. Keeping work clear, consistent, and current.
ATLANTA - June 2, 2016 -There were more than 15.5 million Americans with a history of cancer as of January 1, 2016, a number that is projected to reach more than 20 million by 2026. That's according to Cancer Treatment and Survivorship Statistics, 2016, published in CA: A Cancer Journal for Clinicians, a peer-reviewed journal of the American Cancer Society, and its companion publication for consumers, Cancer Treatment & Survivorship Facts & Figures, 2016-2017.
Pulmonary hypertension is an abnormal elevation of pressure in the pulmonary circulation that results in stress on the heart and remodeling of blood vessels in the lung. Pulmonary hypertension is caused by a variety of factors, and patient prognosis often depends on the underlying cause. Increased stiffness of pulmonary arteries has been linked to increased mortality in patients with pulmonary hypertension, but it is not clear how stiffness develops or drives worsening of disease.
Pancreatic ductal adenocarcinoma is one of the most aggressive and deadliest forms of cancer. Treatment options are limited because symptoms typically do not appear until the disease is advanced and complete surgical resection of tumors is not possible. In this issue of JCI Insight, a group of researchers led by Motoyuki Otsuka at the University of Tokyo describe a pilot study of a new method for detecting a pancreatic cancer biomarker in patient serum. Previous work has shown that an RNA known as human satellite II (HSATII) RNA is highly enriched in human pancreatic cancer tissue.
Dopamine signaling in the kidneys plays a critical role in blood pressure regulation and is responsible for nearly half of the salt and water excretion that occurs in response to increased dietary salt intake. Notably, genetic deletion of any of the 5 dopamine receptors expressed in the kidney causes hypertension in mice. Additionally, genetic polymorphisms in specific dopamine receptor subtypes are associated with susceptibility to kidney injury in humans.
The lungs contain a thin layer of fluid known as the airway surface liquid (ASL), which helps protect against pathogens. The appropriate ASL volume, pH, and ionic composition are required for optimal airway defense. Cystic fibrosis (CF) is caused by expression of a dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR), which acidifies the ASL and renders CF patients more susceptible to lung infections.
The prevalence of frailty in young bone marrow transplant survivors is similar to that seen in the elderly population and frailty is associated with an increased risk of subsequent death, according to a new study published online by JAMA Oncology.