For the first time Japanese researchers discovered that the extracellular domain of taste receptor proteins undergoes a change in structure by binding together taste substances. This structure change is thought to transmit the extracellular binding of taste substances to taste cells. The findings will contribute to our basic understanding of taste mechanisms and the development of a new taste evaluation system that makes use of the screening and detection of taste receptor structure changes.
Body
However you're using the word however, be aware you might be getting it wrong.
A new analysis of more than a century of books, newspapers, magazines and online writings has revealed the life and journey of the word however, but particularly its common misuse as a synonym for but.
University of Melbourne researcher Dr Andrew Hamilton has dubbed the erroneous trend Conjunctive Howeveritis, a phenomenon that peaked in the 1980s and 1990s.
Autophagy (literally "eating of self") is one of the most important process by which cells renew themselves and eliminate components no longer functional. In short, they recycle.
The current view of autophagy portaits two completely separated processes, each one dedicated to remove specific elements. Now a research from the Laboratory of Neurobiology of Movement Disorders, in the Mediterranean Neurological Institute "I.R.C.C.S. Neuromed", Pozzilli (Italy), shows that the two paths converge in a single cell component (organelle): the autophagoproteasome.
Prostate cancer is one of the most common cancers in men. Tumor growth is critically regulated by the androgen receptor, and treatment strategies to lower androgens, such as testosterone, are a mainstay of clinical treatment. Over time, however, resistance frequently develops and the disease may progress to a castration-resistant form that expresses a variant of the androgen receptor, which evades blockade by drugs that dampen androgen receptor signaling.
Patients with cystic fibrosis (CF) suffer from chronic respiratory infections, primarily caused by Pseudomonas aeruginosa, which lead to airway inflammation and damage. Several recent studies have suggested that a specific type of immune cell, known as Th17 cells, produce the factor IL-17 to drive the inflammatory response in the setting of CF lung infection.
Scientists at the University of Southampton have discovered a potential and novel way of preventing asthma at the origin of the disease, a finding that could challenge the current understanding of the condition.
The research, published in The Journal of Clinical Investigation (JCI) Insight, analysed the impact of the gene ADAM33, which is associated with the development of asthma.
A new study by an international team of researchers, affiliated with Ulsan National Institute of Science and Technology (UNIST) has announced that they have succeeded in demonstarting control over the interactions occurring among microscopic spheres, which cause them to self-propel into swarms, chains, and clusters.
A breakthrough into the full characterisation of quantum states has been published today as a prestigious Editors' Suggestion in the journal Physical Review Letters.
The full characterisation (tomography) of quantum states is a necessity for future quantum computing. However, standard techniques are inadequate for the large quantum bit-strings necessary in full scale quantum computers.
Children under the age of 6 are four times as likely to end up in hospital after contact with laundry pod detergent as children exposed to other types of detergent, finds research published online in the journal Injury Prevention.
Nearly three out of four cases were diagnosed as poisoning compared with a similar proportion diagnosed as contact dermatitis for loose liquid or powder detergents, the findings show.
The researchers base their findings on national US data from emergency department visits for children under the age of 5 between 2012 and 2014.
Garden grass could become a source of cheap and clean renewable energy, scientists have claimed.
A team of UK researchers, including experts from Cardiff University's Cardiff Catalysis Institute, have shown that significant amounts of hydrogen can be unlocked from fescue grass with the help of sunlight and a cheap catalyst.
LOS ANGELES -- Research published today in the journal, Nature Communications, provides new insights into the evolution of Mucorales fungi, which cause a fatal infection in ever-increasing segments of patient population, and several molecular pathways that might be exploited as potential therapeutic or diagnostic targets.
People with a variant copy of the TREM2 gene have an increased risk of developing Alzheimer's disease, but researchers are only beginning to understand why.
Thirst is a sensation that we can all relate to; however, dealing with this basic physiological impulse takes on a whole new dimension when an entire bee colony craves water. 'We are interested in the social physiology of honey bee colonies, that is, how they work as physiological units', says Thomas Seeley, from Cornell University, USA, who was curious how the elderly bees that are tasked with gathering water know when the colony's collective thirst is running high.
Little auks forage in the same areas off East Greenland--the continental shelf and its edge--regardless of whether sea ice is present or absent, according to a study published July 20, 2016 in the open-access journal PLOS ONE by Françoise Amélineau, from the University of Montpellier, France, and colleagues.