Body

High intensity interval training reduces tiredness and improves self-esteem for testicular cancer survivors, according to a study published in the British Journal of Cancer today (Tuesday)*.

It found that men who had been treated for testicular cancer and had the lowest fitness levels benefited the most from this strenuous exercise regime.

Clinical researchers at Nationwide Children's Hospital have published one of the first health care studies to examine how behavior aligned with Safety II concepts impacts patient safety. Safety II is a novel approach to patient safety that focuses on why processes perform correctly in high-performing units, as opposed to its predecessor, Safety I, which focuses on why processes fail.

A new study in the Journal of the National Cancer Institute indicates that survivors of uterine cancer are more likely to experience cardiovascular problems years after treatment.

Philadelphia, May 8, 2018 - High levels of cytoskeleton-associated protein 4 (CKAP4) have been identified in the blood of patients with lung cancer. In a novel study in The American Journal of Pathology investigators found that CKAP4 levels were significantly higher in patients with lung cancer than in healthy individuals.

WHO: Aaron Kesselheim, MD, MPH, Director, Program On Regulation Therapeutics And Law (PORTAL), Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital

WHAT: Kesselheim, the senior author of two separate articles published in the May issue of Health Affairs, members of the PORTAL research group and co-authors, examine the fast approvals of precision medicines in one paper while evaluating the impact of the Orphan Drug Act's seven-year market exclusivity in the other.

GALVESTON, Texas -A new collaborative study has identified and studied Ebola antibodies that could be used to design universal therapeutics that are effective against many different Ebola species. The findings were recently published in Nature Microbiology.

The Ebola virus causes a severe illness with high mortality rates in humans. Several strategies have been developed to treat Ebola infection, including ZMapp, which has been shown to be effective in non-human primates and has been used under compassionate-treatment protocols in humans.

ANN ARBOR, Mich. -- New immunotherapy treatments offer a remarkable chance for survival for patients with advanced melanoma and hard-to-treat cancers of the bladder, kidney and lung.

But the treatments, designed to unleash the immune system to attack cancer, can also spur an assault on healthy organs, including the eye.

ANN ARBOR, Mich. -- More than one-third of cirrhosis cases are related to alcohol, a seven-year national study of more than 100 million privately insured people has found.

Among that group, 294,215 people had cirrhosis; 105,871 (36 percent) had alcohol-related cirrhosis. The latter group was sicker and admitted or readmitted to a hospital more often, incurring nearly twice the health care costs per person: $44,835 versus $23,329.

TORONTO-(May 5, 2018)-The volume of carbohydrates, proteins, lipids and calories consumed by very vulnerable preemies significantly contributes to increased brain volume and white matter development, however additional research is needed to determine specific nutritional approaches that best support these infants' developing brains, according to research to be presented during the Pediatric Academic Societies 2018 annual meeting.

Philadelphia, May 4, 2018 - Following the landmark SPRINT trial, there is a growing body of evidence for reducing systolic blood pressure targets, resulting in the development of new US guidelines. However, this has led to many questions about the impact of such fundamental changes in blood pressure management, and whether they should be implemented in other constituencies. Two new studies published in the Canadian Journal of Cardiology assess the benefits and costs of incorporating these more aggressive goals into clinical practice.

Antibody Drug Conjugates (ADCs) are relatively new anti-cancer drugs. They consist of an antibody to which a cell-killing molecule (chemotherapy) is attached. Antibodies can recognize and bind to certain receptors (the 'hands' on the outside of a cell) in a very targeted way. The antibody in an ADC is designed to adhere exclusively to receptors that are characteristic of a tumor cell. The chemotherapy drug is not released until the receptor has brought the entire structure into the cell, and then the chemotherapy drug can do its job.

Inflammation, and in particular chronic inflammation, are major contributors to a large number of diseases, such as cancer, acute pancreatic inflammation, fatty liver disease, diabetes, ulcerative colitis, Crohn's disease, rheumatoid arthritis, chronic liver disease, atherosclerosis, multiple sclerosis, and many others. These pathological conditions are associated with the release of substances, known as pro-inflammatory cytokines, by the immune system. These substances participate in the neutralization of invading pathogens, repair injured tissues, and promote wound healing.

Women who eat less fruit and more fast food take longer to get pregnant and are less likely to conceive within a year, according to a study published today (Friday) in Human Reproduction, one of the world's leading reproductive medicine journals.

Women who eat less fruit and more fast food take longer to get pregnant and are less likely to conceive within a year, according to a study by researchers at the University of Adelaide's Robinson Research Institute.

The study published today (Friday 4 May) in Human Reproduction, one of the world's leading reproductive medicine journals, asked 5598 women in Australia, New Zealand, the UK and Ireland about their diet. The women, who had not had a baby before, were interviewed by research midwives during their first antenatal visit.

Scientists at The University of Texas at Austin have successfully tested in animals a drug that, they say, may one day help block the withdrawal symptoms and cravings that incessantly coax people with alcoholism to drink. If eventually brought to market, it could help the more than 15 million Americans, and many more around the world who suffer from alcoholism stay sober.