Body

In the first prospective study of directly measured body fat distribution and prostate cancer risk, investigators found that higher levels of abdominal and thigh fat are associated with an increased risk of aggressive prostate cancer.

Philadelphia, June 10, 2019 - Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder that leads to significant health issues as well as high treatment costs. In this themed issue of Clinical Therapeutics, published by Elsevier, experts review multiple aspects of RA detection and intervention with the overall goal of moving the field closer to developing effective preventive measures.

Oakland, Calif. -- In a large new Kaiser Permanente study, children who were up to date on their pertussis vaccine schedule were far less likely to develop the disease than unvaccinated children. However, most pertussis cases were in fully vaccinated children. The risk of vaccinated children becoming ill increased with the time since vaccination, suggesting that waning effectiveness between doses was a significant contributor to recent outbreaks.

The study, "Acellular Pertussis Vaccine Effectiveness Over Time," was published on June 10 in the journal Pediatrics.

Key takeaways:

Lowering blood pressure, reducing sodium intake, and eliminating trans fat could prevent 94 million early deaths around the world.

Although scaling up the three interventions globally presents a major challenge, they are both achievable and affordable.

Baltimore (June 9, 2019) - The foods and nutrients a woman consumes while pregnant have important health implications for her and her baby. Nutrition 2019, the annual meeting of the American Society for Nutrition, will feature new research on prenatal vitamins, infant supplements and the impacts of a mother's diet during pregnancy and after the baby is born.

Researchers know that exosomes, tiny nanoparticles released from fat cells, travel through the bloodstream and body, regulating a variety of processes, from growth and development to metabolism. The exosomes are important in lean, healthy individuals in maintaining homeostasis, but when fat gets 'sick' - the most common reason for this is too much weight gain - it can change its phenotype, becoming inflammatory, and disrupts how our organs function, from how our skeletal muscle and liver metabolize sugar to how our blood vessels process cholesterol.

For patients with diabetes, bringing down and maintaining lower blood glucose levels is important to minimize the risk of long-term complications such as nerve damage, kidney damage, an increased risk of heart disease, eye problems, and more. Through a randomized, multicenter clinical trial sponsored by Novo Nordisk, investigators studied blood glucose results for patients assigned to either take insulin (insulin glargine, IGlar U100) or insulin degludec plus liraglutide (IDegLira), a combination of both insulin and an additional medication to help with blood sugar control.

Baltimore (June 8, 2019) - Preliminary findings from a new study reveal that inadequate fruit and vegetable consumption may account for millions of deaths from heart disease and strokes each year. The study estimated that roughly 1 in 7 cardiovascular deaths could be attributed to not eating enough fruit and 1 in 12 cardiovascular deaths could be attributed to not eating enough vegetables.

A novel class of radiopharmaceuticals has proven effective in non-invasively identifying nearly 30 types of malignant tumors, according to research published in the June issue of The Journal of Nuclear Medicine. Using 68Ga-FAPI positron emission tomography/computed tomography (PET/CT), researchers were able to image a wide variety of tumors with very high uptake and image contrast, paving the way for new applications in tumor characterization, staging and therapy.

Bethesda, MD (June 6, 2019) -- For patients taking proton pump inhibitors (PPIs) to treat gastroesophageal disease (GERD) or other acid-related conditions, new research puts safety concerns to rest. In a large, multi-year, randomized trial studying the safety of proton pump inhibitors (PPIs), researchers find no evidence to support claims that PPIs cause serious health issues such as pneumonia, chronic kidney disease, diabetes and dementia.

WEST LAFAYETTE, Ind. -- A 62-year-old with stage IV lung cancer that has spread to his bones, causing unspeakable pain, is trying to convince his physician to prescribe pain medicine. What happens next?

It actually could depend on if the patient is black or white. Or if the physician is a primary care provider or an oncologist.

Yes, race and other factors could play a role, according to a new study conducted by researchers and recently published in the Journal of General Internal Medicine.

For several decades, the number of chronicle diseases has been growing. The main reason for this is the imbalanced diet. Biologists and chemists study natural foods concerning the fact that it can help strengthen health and prevent numerous diseases. They have designed a new concept, which is "functional food products".

WHAT:

Achieving sustained remission of HIV without life-long antiretroviral therapy (ART) is a top HIV research priority, according to a new commentary in JAMA by experts at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

(CAMBRIDGE, Mass.) -- Since their invention in the late 1700s when French-born British physicist Denis Papin, the inventor of the pressure cooker, proposed the piston principle, pistons have been used to harness the power of fluids to perform work in numerous machines and devices.

Some deer are more susceptible to chronic wasting disease that is spreading through herds of white-tailed deer across much of the United States, according to Penn State researchers, who have identified a panel of genetic markers that reliably predict which animals are most vulnerable to the contagious neurological disorder.