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WASHINGTON, September 8, 2020 -- Hepatocellular carcinoma is a particularly stubborn form of cancer with few treatments and a high mortality rate. It is usually treated by blocking the flow of blood to the tumor to induce cancer cell death. The common treatment, transarterial chemoembolization, is invasive and too imprecise to be a local drug delivery method.
The cover for issue 36 of Oncotarget features Figure 7, "Knockdown of APOBEC3B is associated with a lower tumor growth in an adrenocortical carcinoma xenograft mouse model," by Gara, et al.
PHILADELPHIA (September 8, 2020) - HIV prevention remains a public health priority in the United States. Pre-exposure prophylaxis (PrEP) is a drug regimen recommended for individuals who have engaged in behaviors that place them at elevated risk for HIV. When used consistently, daily oral PrEP has been shown to reduce HIV transmission by 99 percent. However, despite increases in PrEP awareness and uptake over the past several years, data show that four of five people who could benefit from PrEP did not access the medication in 2018.
A new Boston University School of Public Health (BUSPH) study maps changes in homicide rates across Brazil from 2000 through 2014. Published in the journal Injury Epidemiology, the research shows the success of anti-violence efforts in major urban areas such as São Paulo, Rio de Janeiro, and Espirito Santo, but the explosion of homicides in fast-developing northeastern areas is a warning for other countries.
A new UCLA study shows partially overlapping patterns of brain function in people with anorexia nervosa and those with body dysmorphic disorder, a related psychiatric condition characterized by misperception that particular physical characteristics are defective.
The study, published in the peer-reviewed journal Brain Imaging and Behavior, found that abnormalities in brain function are related to severity of symptoms in both disorders, and may be useful in developing new treatment methods.
New research from Texas A&M University and the University of Pennsylvania on opioid prescribing practices across the country after outpatient knee surgeries found that prescription strength and number of tablets is prescribed highest in Oklahoma and lowest in Vermont.
The Sheffield researchers founded the spin-out Modulus Oncology with a team of experienced biotech entrepreneurs to fast-track the drug into clinical testing within two years.
A new drug which could improve life expectancy and quality for patients with hard-to-treat cancers, such as pancreatic cancer and relapsed breast cancer, has been invented by scientists at the University of Sheffield.
The researchers founded the spin-out company Modulus Oncology, along with a team of experienced biotech entrepreneurs, to fast-track the drug into clinical testing within two years.
Treatments for kidney cancer have improved considerably over the past few decades. In 1988, when Memorial Sloan Kettering oncologist Robert Motzer started researching the disease, the average survival was less than one year. There were no approved therapies at the time besides surgery. By 2005, with the development of targeted drugs such as sunitinib (Sutent®), survival nearly tripled. Today, with the addition of immunotherapy drugs to these regimens, people with kidney cancer are living even longer, and some even seem to be cured.
Metastases are formed by cancer cells that break away from the primary tumor. A research group at the University of Basel has now identified lack of oxygen as the trigger for this process. The results reveal an important relationship between the oxygen supply to tumors and the formation of metastases. This research may open up new treatment strategies for cancer.
New research led by the University of South Australia shows that a blanket approach to prescribing medication during pregnancy may put low birth weight babies at risk for the rest of their lives.
UniSA and New Zealand fetal physiologists say that smaller fetuses metabolise medication taken by the mother in a less efficient way than normal weight babies, which may lead to long term health consequences.
Thermal imaging has been available for decades to detect temperature differences on the skin that could signal breast cancer without exposing patients to radiation, although the method is not as reliable as mammography.
New research performed at The University of Texas at Dallas and published June 22 in Nature Research's Scientific Reports takes a critical step toward making digital infrared thermal imaging more useful for monitoring breast cancer.
Researchers at Tel Aviv University, led by Prof. Ronit Satchi-Fainaro of TAU's Department of Physiology and Pharmacology at the Sackler School of Medicine, have developed an innovative nanotechnological drug delivery system that significantly enhances the effectiveness of treatment for the aggressive skin cancer melanoma.
BOSTON - A targeted therapy called capmatinib can provide significant benefits to patients who have advanced lung cancer with specific gene mutations, according to recently published results from a phase two clinical trial. The trial, which is published in the New England Journal of Medicine, was conducted by an international team led by investigators at Massachusetts General Hospital (MGH).
BOSTON - A new software program effectively brings the expertise of Massachusetts General Hospital (MGH) specialists to many more patients with Down syndrome (DS), according to a study published today in Genetics in Medicine. Down Syndrome Clinic to You (DSC2U) is a first-of-its kind online health tool aimed at improving adherence to US national Down syndrome guidelines. This study finds the tool effective. Most caregivers and primary care physicians (PCPs) also reported high satisfaction with it.
Jasmin Teurlings is one of 176 million women worldwide who have endometriosis, a chronic, painful gynaecological condition that affects nearly three times as many women as breast cancer.
The 21-year-old University of South Australia (UniSA) journalism student has lived with the condition for five years after first experiencing symptoms at age 16, but it has taken invasive laparoscopic surgery for an official diagnosis.